Search found 1665 matches

by biopearl123
Sat Nov 04, 2023 11:11 pm
Forum: ImetelChat
Topic: Nature Article
Replies: 3
Views: 1771

Re: Nature Article

Mr.G, good question. As you can see on clin trials site, there have been many solid tumor studies from over a decade ago that failed. Nonetheless less, new combinations might be tried or new ways up inhibit telomerase (e.g. MAIA or Geron’s as yet to be revealed, oral agent in early development) coul...
by biopearl123
Sat Nov 04, 2023 9:04 pm
Forum: ImetelChat
Topic: Nature Article
Replies: 3
Views: 1771

Re: Nature Article

Mistergern, yes this seminal article article was first posted on YMB (not by me) and subsequently reposted here on Oct 31st. It’s pretty amazing work that reflects 5 years of nonstop hard work by Dr. Lane and his team with special recognition to the lead author Dr. Claudia Bruedigam. While this is a...
by biopearl123
Fri Nov 03, 2023 7:27 pm
Forum: ImetelChat
Topic: Review or not to review.
Replies: 3
Views: 2830

Re: Review or not to review.

Jay, we were also led to believe priority review was a strong possibility. It didn’t happen. It’s not impossible that the FDA will just approve outright but I wouldn’t hold my breath.
by biopearl123
Fri Nov 03, 2023 3:28 pm
Forum: ImetelChat
Topic: Looks like analyst's have finally done their homework.....
Replies: 1
Views: 931

Re: Looks like analyst's have finally done their homework.....

Kmall, I was amazed at your numbers from several years ago, thinking them perhaps too optimistic. Now they look spot on and sagacious. Remarkable. Anyway, you’re gonna need a bigger boat. The question is will it be in this life or the next…. :). As always, Thanks for your massive contributions here....
by biopearl123
Fri Nov 03, 2023 3:01 am
Forum: ImetelChat
Topic: ADCOM
Replies: 96
Views: 292075

Re: ADCOM

JS says ADCOM 4 to 6 weeks pre PDUFA
by biopearl123
Thu Nov 02, 2023 10:28 pm
Forum: ImetelChat
Topic: Takeaways from today's update....
Replies: 2
Views: 999

Re: Takeaways from today's update....

HI thank you for this distillation. I count 4 abstracts. One oral and three posters. It’s easy to over count with the ASH format such as it is.
by biopearl123
Thu Nov 02, 2023 6:37 pm
Forum: ImetelChat
Topic: ADCOM
Replies: 96
Views: 292075

Re: ADCOM

LWS, enough. We have no idea when the ADCOM meeting will be scheduled. Much more likely to be scheduled much closer to June date. Wishing and repetition does not and will not make it so. You are getting very close to requiring the red pencil.
by biopearl123
Thu Nov 02, 2023 4:11 am
Forum: ImetelChat
Topic: ADCOM
Replies: 96
Views: 292075

Re: ADCOM

KT, to be sure, John can’t be pleased with the FDA and neither should we, or doctors, or patients, or lenders, (oh wait they get more months of interest as the loan payback is delayed) or Wall Street (oh wait, they get to issue more stock and take large fees). So with some exceptions, no one is happ...
by biopearl123
Wed Nov 01, 2023 9:09 pm
Forum: ImetelChat
Topic: ADCOM
Replies: 96
Views: 292075

Re: ADCOM

Where you see agreement, I can assure you there is no agreement and won’t be until the FDA says there is.
by biopearl123
Wed Nov 01, 2023 7:26 pm
Forum: ImetelChat
Topic: So wonderful to see…
Replies: 2
Views: 1287

So wonderful to see…

So wonderful to see Claudia’s youthful crackling intelligence and enthusiasm and Steven’s gravitas. 5 years of hard lab work, no vacations and the reward of a discovery of a new pathway! Can’t wait for the abstracts and preliminary clinical results. Kudos! (Nobel committee take note…)
by biopearl123
Wed Nov 01, 2023 7:20 pm
Forum: ImetelChat
Topic: ADCOM
Replies: 96
Views: 292075

Re: ADCOM

What you are missing is that no amount of wishful thinking will change the FDAs schedule.
by biopearl123
Wed Nov 01, 2023 4:25 pm
Forum: ImetelChat
Topic: Link to Drs. Lane and Bruedigam
Replies: 5
Views: 2398

Re: Link to Drs. Lane and Bruedigam

The case study at the end was unusual as it said nothing about how this lovely lady actually did with Imetelstat. Response? Remission? I suspect heavy censorship until presentations at scientific meetings.
by biopearl123
Tue Oct 31, 2023 6:48 pm
Forum: ImetelChat
Topic: Link to Drs. Lane and Bruedigam
Replies: 5
Views: 2398

Link to Drs. Lane and Bruedigam

https://medicalxpress.com/news/2023-10- ... ncers.html

Even better but not as succinct as ChatGPT!
by biopearl123
Tue Oct 31, 2023 3:34 am
Forum: ImetelChat
Topic: New article hit tip to several on YMB
Replies: 3
Views: 1546

Re: New article hit tip to several on YMB

Gotta love that!
by biopearl123
Mon Oct 30, 2023 3:34 pm
Forum: ImetelChat
Topic: More MAIA drug development
Replies: 0
Views: 6282

More MAIA drug development

https://finance.yahoo.com/news/maia-bio ... 00410.html

Sergei hard at work. HI or CKTC if you are around perhaps revisiting the old Geron patents re Thio might be interesting.
by biopearl123
Thu Oct 26, 2023 10:40 pm
Forum: ImetelChat
Topic: Nov 2nd earning call
Replies: 9
Views: 3412

Nov 2nd earning call

Nov 2nd:earnings call
Nov 2nd: ASH abstract release
by biopearl123
Thu Oct 26, 2023 3:34 pm
Forum: ImetelChat
Topic: Is this new ?
Replies: 2
Views: 1512

Re: Is this new ?

Yes. See topic “more support “ Oct 17th. Lots of familiar names. Was sorry to see MAIA tank on good news. Have never felt ownership of 6 THIO fully settled.
by biopearl123
Wed Oct 25, 2023 5:35 pm
Forum: ImetelChat
Topic: ADCOM
Replies: 96
Views: 292075

Re: ADCOM

I would never recommend thinking in absolutes re Geron. You may not consider the failure of FDA to approve. I could not conceive of Janssen rejecting a Geron partnership. Now I no longer think in terms of absolutes. I highly recommend it.
by biopearl123
Tue Oct 24, 2023 7:53 pm
Forum: ImetelChat
Topic: new article today
Replies: 6
Views: 2531

Re: new article today

Jay, I think Geron optimistically thought they would get priority review and not incur and extra 60 M while waiting. That puts a big dent in any projections to which have been subjected. It seems that every time we are reassured there is enough money to get to X time, they raise.