Search found 1665 matches

by biopearl123
Fri Dec 15, 2023 1:43 am
Forum: ImetelChat
Topic: something to attend
Replies: 2
Views: 5752

Re: something to attend

Great dig, hope some on board can listen in and report back.
by biopearl123
Thu Dec 14, 2023 10:00 pm
Forum: ImetelChat
Topic: Has anyone seen any onc videos post ASH
Replies: 4
Views: 8117

Re: Has anyone seen any onc videos post ASH

Ah, thanks RC, missed reviewing them.
by biopearl123
Thu Dec 14, 2023 8:21 pm
Forum: ImetelChat
Topic: Has anyone seen any onc videos post ASH
Replies: 4
Views: 8117

Re: Has anyone seen any onc videos post ASH

https://www.youtube.com/watch?v=yglG0-C-1TY

Hat tip to Kaz, YMB. “Dismayed and surprised at the lack of QOL improvement with Luspatercept” in contrast to Imetelstat.
by biopearl123
Thu Dec 14, 2023 7:43 pm
Forum: ImetelChat
Topic: Has anyone seen any onc videos post ASH
Replies: 4
Views: 8117

Has anyone seen any onc videos post ASH

Has anyone seen any comments besides the X comments kindly referenced by RC? Usually there is a bunch of video interviews, articles post ASH. So far I have not seen much. Please post if you have. Thansk
by biopearl123
Tue Dec 12, 2023 7:54 pm
Forum: ImetelChat
Topic: Please
Replies: 1
Views: 3734

Please

give it a rest. I will start to limit unnecessarily repetitive posts.
by biopearl123
Tue Dec 12, 2023 6:33 pm
Forum: ImetelChat
Topic: About two weeks
Replies: 4
Views: 9223

About two weeks

Dr. S has a little over 2 weeks to keep his promise to update re oral agent development progress
by biopearl123
Tue Dec 12, 2023 5:10 pm
Forum: ImetelChat
Topic: ADCOM
Replies: 96
Views: 292218

Re: ADCOM

LWS, give it a rest. I will start to limit unnecessarily repetitive posts.
by biopearl123
Tue Dec 12, 2023 3:56 am
Forum: ImetelChat
Topic: Adverse effects
Replies: 8
Views: 11323

Re: Adverse effects

We would have known last month if Geron were granted the honor of a plenary
by biopearl123
Tue Dec 12, 2023 1:02 am
Forum: ImetelChat
Topic: Adverse effects
Replies: 8
Views: 11323

Re: Adverse effects

You are not wrong, it did not.
by biopearl123
Mon Dec 11, 2023 6:02 pm
Forum: ImetelChat
Topic: Adverse effects
Replies: 8
Views: 11323

Re: Adverse effects

True. Bluebird’s box warning was related to the risk of emergence of rare cancers. Fortunately, the grade 3 and 4 events with Imetelstat were not and appear to be reversible.
by biopearl123
Mon Dec 11, 2023 4:48 pm
Forum: ImetelChat
Topic: Adverse effects
Replies: 8
Views: 11323

Adverse effects

There has been some discussion and concern re grade 3 and 4 events which apparently were reversible and did not result in patient deaths. It appears however that the placebo group was also subject to these events although not all were cytopenic events. Will be interesting to hear about how many pati...
by biopearl123
Mon Dec 11, 2023 4:19 am
Forum: ImetelChat
Topic: ASH - twitter
Replies: 10
Views: 12859

Re: ASH - twitter

RC, thanks for posting this. Undoubted we will hear more. We should keep in mind that TI is a pretty high bar and just reducing the transfusion requirement albeit not to zero is an accomplishment. The rise of hemoglobin of 5 gms in many is important to keep in mind.
by biopearl123
Fri Dec 08, 2023 7:04 am
Forum: ImetelChat
Topic: Dr. Patnaik, editorial comment in Lancet
Replies: 10
Views: 17689

Re: Dr. Patnaik, editorial comment in Lancet

KT, thanks for your comments. I am actually ok with Dr. P’s editorial. He is after all an expert and was chosen perhaps because of the ties of the early Imet clinical heme studies to Mayo and Dr. T but undoubtedly also because of his experience, expertise and familiarity with Imetelstat (Mayo probab...
by biopearl123
Thu Dec 07, 2023 11:23 pm
Forum: ImetelChat
Topic: Dr. Patnaik, editorial comment in Lancet
Replies: 10
Views: 17689

Re: Dr. Patnaik, editorial comment in Lancet

KT, I am defending no one but just making an observation. Dr. P has 52 pages of article cited on Pub Med going back over 20 years. It’s hard to find a prominent physician especially in academics that doesn’t have some tie to industry. After all that’s (with the exception of pure funding from foundat...
by biopearl123
Thu Dec 07, 2023 3:10 am
Forum: ImetelChat
Topic: AML competition
Replies: 2
Views: 5375

Re: AML competition

Interesting, thanks for posting Jay.
by biopearl123
Wed Dec 06, 2023 4:02 pm
Forum: ImetelChat
Topic: 50% enrollment
Replies: 3
Views: 5733

Re: 50% enrollment

Jay, watching paint dry. I think we have to remember how COVID dreadfully set back enrollment in many studies. Also there is competition for patients, that’s just a sad fact of enrollment challenges.
by biopearl123
Wed Dec 06, 2023 1:42 am
Forum: ImetelChat
Topic: Dr. Patnaik, editorial comment in Lancet
Replies: 10
Views: 17689

Re: Dr. Patnaik, editorial comment in Lancet

Jay you are not wrong. There are plenty of fruitcakes that hide in academic institutions. And also masquerade as knowing physicians in academics and in the community. The best way to find and avoid them is to ask a nurse. They will tell you who the good guys are. To be clear I am not suggesting this...
by biopearl123
Tue Dec 05, 2023 6:56 pm
Forum: ImetelChat
Topic: What’s bad is good?
Replies: 0
Views: 7081

What’s bad is good?

Some great comments on the board so far. Thanks to those who read my post (hundreds) and to those who posted comments. I have a few thoughts to share. So to Kmall, a man with a VERY good memory. Yes that was an exact quote, more later. First a couple of thoughts pertinent to therapies in use today t...