Search found 246 matches

by huntingonthebluffs
Thu Aug 26, 2021 6:40 pm
Forum: ImetelChat
Topic: A window into November
Replies: 3
Views: 1401

Re: A window into November

Good information biopearl123, I think that is exactly why Geron is using the DM terminology with the idea that Imetelstat is clearly differentiated from competition available or in development! I think there is more here than meets the eye. Dr. Mascarenhas actually let some of that out of the bag so...
by huntingonthebluffs
Wed Aug 25, 2021 6:09 am
Forum: ImetelChat
Topic: Today's Conference call
Replies: 6
Views: 2855

Re: Today's Conference call

Good questions Zhears. I am merely a retired investor so can’t answer the questions although I do have two cents worth of opinions. Other members here should share their thoughts as well. I do think lack of activity can be meaningful and in the case of Geron options, it is a little strange to see so...
by huntingonthebluffs
Wed Aug 18, 2021 7:39 pm
Forum: ImetelChat
Topic: Today's Conference call
Replies: 6
Views: 2855

Re: Today's Conference call

Hi Zhears, agreed as it seems we never get all our pressing questions answered. It is always prudent to be a contrarian especially with a pre-commercial biotech. The Form 10Q report submitted to the SEC, contains COVID-19 info ad nauseum so they have focused heavily on the associated risks. It is pr...
by huntingonthebluffs
Tue Aug 17, 2021 10:30 pm
Forum: ImetelChat
Topic: Today's Conference call
Replies: 6
Views: 2855

Re: Today's Conference call

Agreed! This was a great CC by Dr. John Scarlett and his executive team, maybe a watershed point. And to your comments biopearl123, it was polished, positive, optimistic, answered some key questions and covered several new subjects. And to your point rccola335, stay tuned in reference to a partner, ...
by huntingonthebluffs
Tue Aug 17, 2021 9:16 pm
Forum: ImetelChat
Topic: The Double Blind Placebo Controlled Trial: The Fool's Gold Standard
Replies: 9
Views: 2751

Re: The Double Blind Placebo Controlled Trial: The Fool's Gold Standard

Thanks ashah for the info on the crossover. It was right there in front of me but I stopped reading just before and concluded incorrectly. The other thing from the CC yesterday was the MF study is not double blinded per Dr. Rizo, it is only randomized. Of course that is also stated in the CT info bu...
by huntingonthebluffs
Tue Aug 17, 2021 12:13 am
Forum: ImetelChat
Topic: The Double Blind Placebo Controlled Trial: The Fool's Gold Standard
Replies: 9
Views: 2751

Re: The Double Blind Placebo Controlled Trial: The Fool's Gold Standard

Thanks biopearl123 for keeping this on track and to be fair, the MF P3 study has a comparator of best available therapy (BAT) which is investigator-selected non-JAK-inhibitor treatment and not a placebo. However, for the most part it seems to me it is a blank load for the R/R patients, just not tech...
by huntingonthebluffs
Mon Aug 16, 2021 8:01 pm
Forum: ImetelChat
Topic: The Double Blind Placebo Controlled Trial: The Fool's Gold Standard
Replies: 9
Views: 2751

Re: The Double Blind Placebo Controlled Trial: The Fool's Gold Standard

Okay, so I may be standing out in the wilderness mostly alone on this but the gold standard could be interpreted more than one way, for example to mean the majority of phase 3 trials using a placebo which could benefit study quality and/or not be significantly detrimental to the patients is one way ...
by huntingonthebluffs
Mon Aug 16, 2021 12:45 am
Forum: ImetelChat
Topic: Some Hematology Basics
Replies: 11
Views: 3129

Re: Some Hematology Basics

Thanks all for the nice comments. And I appreciate the follow-up kmall! So I did find biopearl123’s post (Reality check – on July 20, 2018). Those are significant numbers and I assume the FDA or any health regulatory or medical entity would not overlook such critical potential and add their support ...
by huntingonthebluffs
Thu Aug 12, 2021 6:12 pm
Forum: ImetelChat
Topic: JCO editorial
Replies: 3
Views: 1439

Re: JCO editorial

Thank you biopearl123 for posting the link to this MDS article. I found it covering the scope and depth of the disease in an enlightening way. For me, it provided perspective on the treatment paradigms for both low and high risk MDS and attempts to tie the various MDS therapeutic options together in...
by huntingonthebluffs
Wed Aug 11, 2021 6:00 am
Forum: ImetelChat
Topic: The Double Blind Placebo Controlled Trial: The Fool's Gold Standard
Replies: 9
Views: 2751

The Double Blind Placebo Controlled Trial: The Fool's Gold Standard

https://www.sskrplaw.com/the-double-blind-placebo-controlled-trial-the-fool-s-gold-standa.html Someone posted this on the YMB a few days ago. When went back to see who posted it, it apparently had been erased. This document was on a law firms website publications tab. I found it very interesting and...
by huntingonthebluffs
Fri Aug 06, 2021 8:54 pm
Forum: ImetelChat
Topic: Curis CEO:
Replies: 1
Views: 1091

Re: Curis CEO:

Listening to the CRIS earnings call highlights several differences between CRIS / Geron management and the drugs and their targets. Given the current state of their studies with Geron considerably ahead in my opinion, comparing DM statements might be a fool’s game. CRIS CEO Jim Dentzer is very marke...
by huntingonthebluffs
Fri Jul 30, 2021 11:39 pm
Forum: ImetelChat
Topic: Geron’s social media efforts to support enrollment in CTs
Replies: 5
Views: 2423

Re: Geron’s social media efforts to support enrollment in CTs

ashah, thanks for your thoughts, you make a good point in that the work in the trenches, SOP, blocking and tackling etc. must come first, the ante so to speak. However, I do think getting the CTs fully enrolled is both critical and strategic, not icing or cheerleading. If the CTs are filling nicely,...
by huntingonthebluffs
Fri Jul 30, 2021 10:43 pm
Forum: ImetelChat
Topic: Some Hematology Basics
Replies: 11
Views: 3129

Re: Some Hematology Basics

Lastly, here are a couple things I’ve recently picked up that I think are of interest and probably informative for some of us. First link is an article is by Dr. John Mascarenhas including info on patients that are triple negative: Understanding Genetic Mutations in Primary Myelofibrosis When should...
by huntingonthebluffs
Fri Jul 30, 2021 10:40 pm
Forum: ImetelChat
Topic: Some Hematology Basics
Replies: 11
Views: 3129

Re: Some Hematology Basics

Part VI: Clinical Trials (MF / MDS): I think we all have a little time here to do some due diligence regarding the various drugs in CTs that may help patients with these diseases and why, help us better understand the enormity of the competitive landscape and learn more about the challenges for a p...
by huntingonthebluffs
Fri Jul 30, 2021 10:37 pm
Forum: ImetelChat
Topic: Some Hematology Basics
Replies: 11
Views: 3129

Re: Some Hematology Basics

Part V: Complete Blood Count (CBC) NOW, I’m going to chime in here!! If you get annual checkups and have never gotten a complete blood count (CBC), please ask for one on your next checkup or just your next doctor’s appointment and take the time to study the results yourself. Also, ask them to inclu...
by huntingonthebluffs
Fri Jul 30, 2021 10:32 pm
Forum: ImetelChat
Topic: Some Hematology Basics
Replies: 11
Views: 3129

Re: Some Hematology Basics

Part IV: Who needs a blood transfusion and what are the risks? You may need a blood transfusion if you have anemia, sickle cell disease, a bleeding disorder such as hemophilia, cancer or severe injury. For people in critical condition, blood transfusions can be lifesaving. Four types of blood produ...
by huntingonthebluffs
Fri Jul 30, 2021 10:28 pm
Forum: ImetelChat
Topic: Some Hematology Basics
Replies: 11
Views: 3129

Re: Some Hematology Basics

Part III: Blood supply / requirements / transfusions: Blood supply and requirements in the US: https://www.redcrossblood.org/donate-blood/how-to-donate/how-blood-donations-help/blood-needs-blood-supply.html The Red Cross provides about 40% of our nation’s blood and blood components, all from genero...
by huntingonthebluffs
Fri Jul 30, 2021 10:24 pm
Forum: ImetelChat
Topic: Some Hematology Basics
Replies: 11
Views: 3129

Re: Some Hematology Basics

Part II: Some basic blood information: I found this part as a refresher yet interesting. If you took all the blood vessels out of an average child and laid them out in one line, the line would stretch over 60,000 miles. An adult's would be closer to 100,000 miles long. There are three kinds of bloo...
by huntingonthebluffs
Fri Jul 30, 2021 10:19 pm
Forum: ImetelChat
Topic: Some Hematology Basics
Replies: 11
Views: 3129

Some Hematology Basics

Well here we are, in the so-called data desert and discussing hematology basics is one way to pass the time. Like many here, I’ve had to do a lot of reading and rereading to understand some of the basics in the Imetelstat space. Hopefully what follows can be of help to those just starting to learn a...
by huntingonthebluffs
Mon Jul 26, 2021 8:55 pm
Forum: ImetelChat
Topic: Geron’s social media efforts to support enrollment in CTs
Replies: 5
Views: 2423

Geron’s social media efforts to support enrollment in CTs

FWIW, I may not be seeing all Geron's efforts but it does not appear to me that Geron is as aggressively promoting Imetelstat or related CTs via social media as I thought they would. I expected much wider/deeper efforts especially with the pandemic enrollment issues, etc. Given I’m not particularly ...