Search found 1665 matches

by biopearl123
Thu Jan 11, 2024 3:24 pm
Forum: ImetelChat
Topic: 50 New Positions Posted Today.........
Replies: 11
Views: 4241

Re: 50 New Positions Posted Today.........

Kmall, agree. Geron could support this sales force for 5 years with just the extra burden imposed by the FDA delay.
by biopearl123
Tue Jan 09, 2024 3:38 pm
Forum: ImetelChat
Topic: ICER - Institute for Clinical and Economic Review
Replies: 5
Views: 1212

Re: ICER - Institute for Clinical and Economic Review

Thanks for the background, pretty impressive advisory board. Will be interesting to see what their analysis reveals. It appears as a non profit, that they could be self appointed watch dogs to reign in or at least shine a spotlight on excessive medical costs. We really don’t know how Imetelstat will...
by biopearl123
Tue Jan 09, 2024 2:27 pm
Forum: ImetelChat
Topic: ICER - Institute for Clinical and Economic Review
Replies: 5
Views: 1212

Re: ICER - Institute for Clinical and Economic Review

Ryan, thanks for posting. Can you give us a primer on who ICER is and would would have commissioned this review (Geron, FDA, Pharmas?). thanks, bp
by biopearl123
Tue Jan 09, 2024 3:04 am
Forum: ImetelChat
Topic: 50 New Positions Posted Today.........
Replies: 11
Views: 4241

Re: 50 New Positions Posted Today.........

Wow, that’s a lot of positions. I think these positions are basically for “drug reps” who will call on doctors, hospitals and pharmacists. There are 50 of them. One person can not cover an entire state or other widely defined geography, especially if “50%” of the time they are traveling. Geron is bu...
by biopearl123
Sun Jan 07, 2024 6:12 pm
Forum: ImetelChat
Topic: Off-Topic - GERN stock
Replies: 4
Views: 1519

Re: Off-Topic - GERN stock

Geron has added (at expense) many layers of experts including those who specialize in being sure all the FDA t’s are crossed and i’s dotted. MA should be highly likely bolstered by virtually every expert we have heard who makes a point of emphasizing that the grade 3 and 4 cytopenias are actually “o...
by biopearl123
Sat Jan 06, 2024 10:22 pm
Forum: ImetelChat
Topic: 3 days ago
Replies: 1
Views: 815

Re: 3 days ago

Thanks RC. Good presentation with Imet highlights. What is striking to me is the willingness to offer BMT even to prolong life for a few months. An effective treatment agent is what they want especially one that modifies disease. For those who are “concerned/critical” of Imetelstats adverse effects,...
by biopearl123
Fri Dec 29, 2023 7:45 pm
Forum: ImetelChat
Topic: A few thoughts for the end of the old year and the beginning of the new
Replies: 5
Views: 2163

Re: A few thoughts for the end of the old year and the beginning of the new

MG, nice! Thanks for sharing and best wishes for the New Year.
by biopearl123
Thu Dec 28, 2023 7:19 pm
Forum: ImetelChat
Topic: A few thoughts for the end of the old year and the beginning of the new
Replies: 5
Views: 2163

A few thoughts for the end of the old year and the beginning of the new

2024 should be quite the year for us. Despite recent poorly researched hit articles (be careful where you get your advice, especially here!), 2024 should reveal new AML data, a window into the oral agent development and of course FDA approval. A few recent comments from the experts bear emphasis. I ...
by biopearl123
Thu Dec 28, 2023 12:11 am
Forum: ImetelChat
Topic: Thank you AGAIN Kaz, YMB
Replies: 2
Views: 1196

Re: Thank you AGAIN Kaz, YMB

RC either we are missing something or the FDA is. You know who gets my vote.
by biopearl123
Wed Dec 27, 2023 7:45 pm
Forum: ImetelChat
Topic: Audentes Fortuna Luvat
Replies: 0
Views: 1221

Audentes Fortuna Luvat

Nice shout out to Geron from Dr Zeidan for persistence in the face of Janssen hissy fit.
by biopearl123
Wed Dec 27, 2023 5:04 pm
Forum: ImetelChat
Topic: Thank you AGAIN Kaz, YMB
Replies: 2
Views: 1196

Thank you AGAIN Kaz, YMB

youtu.be/EeqbocpDmGI?si=YiL6A9aQOM6ye-Ce
by biopearl123
Tue Dec 26, 2023 12:53 am
Forum: ImetelChat
Topic: Putting 6-thio-Dg into perspective
Replies: 15
Views: 14411

Re: Putting 6-thio-Dg into perspective

CKTC, I was hoping this patent might get your attention. Thanks for sharing your thoughts. I can’t imagine Geron would just roll on this without attempting some agreement on royalties (or merger—time to come home Sergei?) Happy holidays to all. bp
by biopearl123
Fri Dec 22, 2023 4:56 am
Forum: ImetelChat
Topic: Kaz yet again keep them coming
Replies: 2
Views: 1183

Re: Kaz yet again keep them coming

RC, yes, this one is worth a careful listen even though it is very short. Points made: that Lus doesn’t seem to promote the malignant clone was viewed as good news. But no statement as to whether Lus suppresses the malignant clone. Dr. Brenner foresees the day when early disease can be detected and ...
by biopearl123
Fri Dec 22, 2023 4:39 am
Forum: ImetelChat
Topic: 2023 - What a Long, Strange Trip it’s Been
Replies: 3
Views: 2762

Re: 2023 - What a Long, Strange Trip it’s Been

HI and Ryan, I agree. Highly doubtful we will see Imet 2.0 before the end of the year. Another over promise and under deliver, Yes, John, you did say by the end of the year. I have to wonder (again) if the envelope between the intentional and unintentional is breached with intent or just irrational ...
by biopearl123
Thu Dec 21, 2023 11:01 am
Forum: ImetelChat
Topic: Kaz yet again keep them coming
Replies: 2
Views: 1183

Kaz yet again keep them coming

Many thanks:


youtu.be/Dlv2jcS3bQ4?si=CtmFzwLzsuX41n5Y

https://m.youtube.com/watch?si=CtmFzwLz ... e=youtu.be
by biopearl123
Wed Dec 20, 2023 6:20 pm
Forum: ImetelChat
Topic: CKTC
Replies: 2
Views: 2900

CKTC

Been thinking about your last post. Here’ MAIA with an “elegant” drug with advantages at least in theory over Imetelstat and significant human assets like Sergei M. Gryaznov and Jerry Shay both of whom were once part of Geron. And yet… And yet, they seem to be way behind in clinical development and ...
by biopearl123
Wed Dec 20, 2023 5:14 pm
Forum: ImetelChat
Topic: Putting 6-thio-Dg into perspective
Replies: 15
Views: 14411

Re: Putting 6-thio-Dg into perspective

CKTC, thanks as always for posting. I do wonder if the lag time for Imetelstat is much less of an issue with AML since the cell doubling time is measured in hours. Also the “non canonical” effects of Imetelstat, now known to be related to ferroptosis effects might be at play. Of course the subtext o...
by biopearl123
Sun Dec 17, 2023 6:16 pm
Forum: ImetelChat
Topic: Hat tip again to Kaz YMB
Replies: 1
Views: 4740

Hat tip again to Kaz YMB

https://www.youtube.com/watch?v=EfI-CqCMubw https://www.youtube.com/watch?v=EfI-CqCMubw Rami says ADCOM in April Other salient feature, Grade 3-4 neutropenia in 68 % (manageable and transient) but notably only 1% with febrile neutropenia. It’s a stretch and a guess but regarding the need for hospita...