Search found 1665 matches
- Tue Feb 27, 2024 9:00 pm
- Forum: ImetelChat
- Topic: ODAC
- Replies: 0
- Views: 910
ODAC
https://www.regulations.gov/document/FDA-2024-N-0016-0001 Comments submitted before Feb 29th will be presented to the committee. Comments after that date will be taken into consideration by the FDA. If you or anyone you know want their comments considered, there is a time deadline. So far only a few...
- Tue Feb 27, 2024 6:06 am
- Forum: ImetelChat
- Topic: A blessing from the hepatologists Major hat tip to Wildrides YMB
- Replies: 5
- Views: 1534
Re: A blessing from the hepatologists Major hat tip to Wildrides YMB
Ryan, are you surprised? I think this is the tip of the iceberg.
- Tue Feb 27, 2024 3:38 am
- Forum: ImetelChat
- Topic: A blessing from the hepatologists Major hat tip to Wildrides YMB
- Replies: 5
- Views: 1534
- Mon Feb 26, 2024 5:27 am
- Forum: ImetelChat
- Topic: The cost to develop a new drug
- Replies: 4
- Views: 1085
The cost to develop a new drug
Yes we have seen a lot of dilution but how much would Janssen have spent to do the same for Imetelstat?
https://www.genengnews.com/gen-edge/the ... 3-billion/
https://www.genengnews.com/gen-edge/the ... 3-billion/
- Thu Feb 22, 2024 4:24 am
- Forum: ImetelChat
- Topic: Blood
- Replies: 3
- Views: 930
Blood
I have reviewed the recent discussion. We have much to learn from other species and as Jerry Garcia would say, “the wonders of nature”. Kmall’s posts remind us of the amazing beauty around us and how the species intertwine and the respect we should have for our fragile ecosystem. Who would know that...
- Wed Feb 21, 2024 9:32 pm
- Forum: ImetelChat
- Topic: THANK YOU IMETELCHAT BOARD !!!!!
- Replies: 19
- Views: 2190
Re: THANK YOU IMETELCHAT BOARD !!!!!
I am traveling and will give this thread the scrutiny it deserves when I can
- Wed Feb 21, 2024 1:49 am
- Forum: ImetelChat
- Topic: A wonderful summation of the state of things
- Replies: 4
- Views: 890
A wonderful summation of the state of things
This is the opening paragraph of a paper by Chandhok and Sekeres in "Leukemia" Feb 15th which I can't copy here sums up the sorry state of affairs in the current treatment of LR/MDS and confirms the absence of data to support improved survival (with current treatment) and the dreadful dependence of ...
- Tue Feb 20, 2024 5:33 pm
- Forum: ImetelChat
- Topic: Everything is relative
- Replies: 3
- Views: 574
Re: Everything is relative
Kmall, I stand happily corrected on both points
- Tue Feb 20, 2024 4:09 pm
- Forum: ImetelChat
- Topic: Everything is relative
- Replies: 3
- Views: 574
Everything is relative
Some as asked for a reckoning of side effects from Imetelstat. Fair enough. I think however having some framework that allows evaluation of alternatives help with perspective. Let’s start with the side effects of blood transfusions: 1. Volume overload (many patients with MPD have concurrent vascular...
- Mon Feb 19, 2024 10:23 pm
- Forum: ImetelChat
- Topic: FDA v. Geron
- Replies: 31
- Views: 6879
Re: FDA v. Geron
The editorial written by Dr. Patniak is summarized in my Dec 5th post. You do have access if you wish, there is a modest fee to Lancet for time limited access.
- Mon Feb 19, 2024 4:56 pm
- Forum: ImetelChat
- Topic: FDA v. Geron
- Replies: 31
- Views: 6879
Re: FDA v. Geron
LWS, like many things in life, this is not binary. It might be valuable to go back and review the Mayo editorial in Lancet which tries to balance a ringing endorsement with an an examination of the potential flaws in the IMerge study and the cautionary approach that must be used with any completely ...
- Mon Feb 19, 2024 12:09 am
- Forum: ImetelChat
- Topic: THANK YOU IMETELCHAT BOARD !!!!!
- Replies: 19
- Views: 2190
- Sun Feb 18, 2024 4:17 pm
- Forum: ImetelChat
- Topic: meanwhile, back on topic
- Replies: 25
- Views: 3990
Re: meanwhile, back on topic
Jay, I could be wrong but the way I read it is that these are options to buy stock at 2.10 anytime over the next ten years were awarded as a from of incentive/compensation. They own the options to buy. If the stock goes up it’s a bargain, they can buy at 2.10 if it goes down the options are worthles...
- Sun Feb 18, 2024 3:20 am
- Forum: ImetelChat
- Topic: meanwhile, back on topic
- Replies: 25
- Views: 3990
Re: meanwhile, back on topic
These are option awards with a 2034 expiration date.
- Sun Feb 18, 2024 12:32 am
- Forum: ImetelChat
- Topic: meanwhile, back on topic
- Replies: 25
- Views: 3990
Re: meanwhile, back on topic
Seedylemon, I think it might be worth trying to clarify your post. Dr. Scarlett along with other officers received option awards that can be exercised for a certain price anytime over the next ten years. That is not the same as buying shares outright or exercising options to guarantee a specific pri...
- Sat Feb 17, 2024 5:21 pm
- Forum: ImetelChat
- Topic: meanwhile, back on topic
- Replies: 25
- Views: 3990
Re: meanwhile, back on topic
Jay I have only seen recent options awarded but not redeemed. I probably missed the ones that were redeemed can you remind us? Thanks, bp
- Wed Feb 14, 2024 7:12 pm
- Forum: ImetelChat
- Topic: meanwhile, back on topic
- Replies: 25
- Views: 3990
Re: meanwhile, back on topic
Thanks Jay, course corrections always appreciated.
- Wed Feb 14, 2024 6:07 pm
- Forum: ImetelChat
- Topic: Will NOAA take action while the FDA stands on the sidelines?
- Replies: 14
- Views: 1875
Re: Will NOAA take action while the FDA stands on the sidelines?
I am good for it, send by seagull?
- Wed Feb 14, 2024 5:11 pm
- Forum: ImetelChat
- Topic: Will NOAA take action while the FDA stands on the sidelines?
- Replies: 14
- Views: 1875
Re: Will NOAA take action while the FDA stands on the sidelines?
Waddya mean you’d bet a dollar, you already owe me a dollar, oh wait maybe I owe you the dollar, can’t remember. Nevermind.
- Wed Feb 14, 2024 3:58 pm
- Forum: ImetelChat
- Topic: Will NOAA take action while the FDA stands on the sidelines?
- Replies: 14
- Views: 1875
Re: Will NOAA take action while the FDA stands on the sidelines?
Kmall, pretty sure Dr. Scarlett starts his day with a cup of coffee and a visit to this board. It is highly likely your concerns well be viewed by him and considered. He of all people has the means and interest.