Search found 531 matches
- Mon Feb 22, 2016 11:08 pm
- Forum: ImetelChat
- Topic: Geron - Imetelstat achievements since 2014
- Replies: 14
- Views: 10249
Re: Geron - Imetelstat achievements since 2014
So IMbark has 76 locations now of which recruiting: Duarte, California, United States La Jolla, California, United States Louisville, Kentucky, United States Baltimore, Maryland, United States Rochester, Minnesota, United States St. Louis, Missouri, United States Bronx, New York, United States New Y...
- Mon Feb 22, 2016 10:53 pm
- Forum: ImetelChat
- Topic: Geron - Imetelstat achievements since 2014
- Replies: 14
- Views: 10249
Re: Geron - Imetelstat achievements since 2014
Hi Bio, as I said, comments and improvements are appreciated. So let's start making this list more precise. What are your other observations?
- Mon Feb 22, 2016 5:23 pm
- Forum: ImetelChat
- Topic: Geron - Imetelstat achievements since 2014
- Replies: 14
- Views: 10249
Geron - Imetelstat achievements since 2014
I revisited an earlier overview from YMB of Geron's state of play since 2nd part of 2014. I am reposting it here, including some new facts. (version 5, updated 15 July 2016) on imetelstat: 1. partial clinical hold lifted; 2. 3 x ODD status: for MF in the US and EU, for MDS in the US 4. JnJ deal with...
- Mon Feb 22, 2016 3:59 pm
- Forum: ImetelChat
- Topic: Time Line
- Replies: 3
- Views: 2430
Re: Time Line
Maybe a first atempt to set up a timeline based on events/milestones: Clinical: Imbark & Imerge: early readouts CT1951: Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome measure); Can we expect other milestones from this study? AML: start clinical combi-tr...
- Sun Feb 21, 2016 11:18 am
- Forum: ImetelChat
- Topic: Time Line
- Replies: 3
- Views: 2430
Re: Time Line
btw: irish is here, as well as known experts such as Phil, Greg BioPearl and Hoosier. Good ingredients to start a good discussion, I would say....
- Sun Feb 21, 2016 11:14 am
- Forum: ImetelChat
- Topic: Time Line
- Replies: 3
- Views: 2430
Re: Time Line
Hi idomer, welcome here! Good suggestion: any form serious discussion is highly appreciated. Speculating about timelines is especially interesting, because for that we need to try to see the unkowns based on what we do know. So let's start the discussion and see how much we can get to the table! The...
- Fri Feb 19, 2016 1:58 pm
- Forum: ImetelChat
- Topic: More PreMF patients within ET cohorts than currently diagnosed
- Replies: 7
- Views: 4741
More PreMF patients within ET cohorts than currently diagnosed
It already has been said at other occasions: ET is not so 'innocent' as we may think. This article suggests that there are significantly more PreMF cases amongst ET diagnosed patients than we currently acknowledge. That means that imetelstat may very well play a life saving role for a significant su...
- Sun Feb 14, 2016 8:01 pm
- Forum: ImetelChat
- Topic: Dr. Raajit Rampal speaks about imetelstat
- Replies: 0
- Views: 2313
Dr. Raajit Rampal speaks about imetelstat
(from September 2015; I didn't see it before) Women and MPN Conference, San Diego 11-12 September 2015 Genetics and Targeted Therapy of MPN, by Dr. Raajit Rampal MD At 23:55 of the video he speaks about imetelsat, its mechanism and the promising results as reported by Tefferi, Baerlocher and NEJM. l...
- Sat Feb 13, 2016 11:32 pm
- Forum: ImetelChat
- Topic: On another note...
- Replies: 8
- Views: 6378
Re: On another note...
I see...Tx
- Sat Feb 13, 2016 11:29 pm
- Forum: ImetelChat
- Topic: Why Incyte's Shares Are Tumbling (Motley Fool, 11-02-2016)
- Replies: 0
- Views: 2247
Why Incyte's Shares Are Tumbling (Motley Fool, 11-02-2016)
Jakafi's solid tumor program goes belly up. by George Budwell What: Shares of Incyte Corporation (NASDAQ:INCY) fell by more than 21% in early morning trading today after the company announced that it is discontinuing the clinical development of Jakafi (ruxolitinib) in solid tumors due to insufficien...
- Sat Feb 13, 2016 10:10 am
- Forum: ImetelChat
- Topic: On another note...
- Replies: 8
- Views: 6378
Re: On another note...
Wow, you are right, Bio. I missed that second press release. Doesn't look good for pacritinib....
Link: http://www.prnewswire.com/news-releases ... 17839.html
(btw: who is Kemosabe?)
Link: http://www.prnewswire.com/news-releases ... 17839.html
(btw: who is Kemosabe?)
- Fri Feb 12, 2016 8:24 pm
- Forum: ImetelChat
- Topic: On another note...
- Replies: 8
- Views: 6378
Re: On another note...
Bio, the Citi press release says it's a partial hold. SEATTLE, Feb. 8, 2016 /PRNewswire/ -- CTI BioPharma Corp. (CTI BioPharma) (NASDAQ and MTA:CTIC) today announced that the Company received written communication from the U.S. Food and Drug Administration (FDA) on February 4, 2016, that the FDA has...
- Fri Feb 12, 2016 10:51 am
- Forum: ImetelChat
- Topic: The JAK inhibitor competition, and why Imetelstat out-classes them all
- Replies: 0
- Views: 1944
The JAK inhibitor competition, and why Imetelstat out-classes them all
repost from sdrawkcabeman (YMB) Everyone's familiar w/Rux's profile which, broadly, is very modest efficacy w/myelosuppression, abnormal LFTs, and up to 89% discontinuation w/in 3 yrs. SNY's Fedratinib was scrapped b/c pts developed Wernicke's encephalopathy. The whole program was written off, this ...
- Thu Feb 11, 2016 5:07 pm
- Forum: ImetelChat
- Topic: 1951 study
- Replies: 3
- Views: 2890
Re: 1951 study
Hi Bio, I will get into it later today, as I am a bit busy right now. Btw: changes on the CT site are not just administrative matters. Changing texts have a good wellthough off reasoning behind. Let's see if we can get a grasp of the wider meaning of these changes.
- Wed Feb 10, 2016 11:13 pm
- Forum: ImetelChat
- Topic: On another note...
- Replies: 8
- Views: 6378
Re: On another note...
This is about pacritnib?
- Wed Feb 10, 2016 6:56 pm
- Forum: ImetelChat
- Topic: 1951 study
- Replies: 3
- Views: 2890
Re: 1951 study
Bio, you raise a very interesting point. I will take a closer at this later, as I am a bit in a hurry. For now I see three significant changes: - duration from 3 to 5 years - the definition of the study-end is changed - they skipped the wordings 'unacceptable toxicity' and changed it into 'as long a...
- Wed Feb 10, 2016 1:07 pm
- Forum: ImetelChat
- Topic: Novel Efficient Cell-Penetrating Peptide-Mediated Strategy
- Replies: 5
- Views: 3529
Re: Novel Efficient Cell-Penetrating Peptide-Mediated Strategy
This is the link to the abstract: http://online.liebertpub.com/doi/abs/10 ... .2015.0558
(I couldn't find a link to the PDF you mentioned)
(I couldn't find a link to the PDF you mentioned)
- Mon Feb 08, 2016 9:14 pm
- Forum: ImetelChat
- Topic: A New Tool for Predicting Marketing Approval of Oncology Drugs (JNJ/Tufts University)
- Replies: 1
- Views: 2075
Re: A New Tool for Predicting Marketing Approval of Oncology Drugs (JNJ/Tufts University)
Phil Pecsok from Seeking Alpha said the following about this tool when applied to imetelstat: ====== This is THE algo that JANSSEN considered when it partnered with Geron. Go to page 4. Note scores are 0-1-2 for each of 4 questions. #1. IMET has 40% activity if you look at CR/PR/CI and higher if you...
- Mon Feb 08, 2016 9:03 pm
- Forum: ImetelChat
- Topic: A New Tool for Predicting Marketing Approval of Oncology Drugs (JNJ/Tufts University)
- Replies: 1
- Views: 2075
A New Tool for Predicting Marketing Approval of Oncology Drugs (JNJ/Tufts University)
Authors: Tufts Center for the Study of Drug Development and Janssen Research & Development R&D Senior Leadership Brief (excerpt of the summary) Starting in 2012, the Tufts Center for the Study of Drug Development (Tufts CSDD) and Janssen Research & Development (JRD) collaborated on a pilot study to ...
- Mon Feb 08, 2016 5:40 pm
- Forum: ImetelChat
- Topic: Pacritinib on Partial Hold
- Replies: 1
- Views: 1632
Re: Pacritinib on Partial Hold
Yes, it is a competing drug. So maybe good news for Geron. But for patients it is bad news, because it performed better than Jakafi.... With the requested changes to the protocol the FDA wants to get a better insight in the mortality cases, partly by not allowing patients crossing over to the other ...