Search found 1665 matches

by biopearl123
Mon Feb 05, 2024 10:15 pm
Forum: ImetelChat
Topic: Morphosys very active
Replies: 1
Views: 678

Morphosys very active

A lot of activity here…
by biopearl123
Fri Feb 02, 2024 2:01 am
Forum: ImetelChat
Topic: Enjoy
Replies: 4
Views: 1792

Re: Enjoy

Agree, “hemoglobin” is just a number. These docs clearly want their patients to feel better too, not to mention live longer, not just have better labs.
by biopearl123
Fri Feb 02, 2024 12:08 am
Forum: ImetelChat
Topic: Enjoy
Replies: 4
Views: 1792

Re: Enjoy

Thanks for posting this RC, it’s not hard to see where this is going. Earlier treatment before transfusion dependence and a better awareness of the role of inflammation impacting concurrent cardiovascular diseases. We have discussed the anti inflammatory effects of Imetelstat several times over the ...
by biopearl123
Thu Feb 01, 2024 2:57 am
Forum: ImetelChat
Topic: New article Hat tip to YMB
Replies: 1
Views: 1349

Re: New article Hat tip to YMB

Here’s the full link:

https://www.nature.com/articles/s43018-023-00653-5

Claudia hard at work!
by biopearl123
Thu Feb 01, 2024 12:22 am
Forum: ImetelChat
Topic: less competition
Replies: 5
Views: 1761

Re: less competition

Hi Ryan, thanks for sharing your thoughts. I also would certainly hope Dr. Steensma would weigh in, in March. He clearly has been pleased with the LR results and was lead author on the JCO article. We have reviewed articles on this board that suggest that LR and HR/MDS are not necessarily different ...
by biopearl123
Wed Jan 31, 2024 6:36 pm
Forum: ImetelChat
Topic: less competition
Replies: 5
Views: 1761

Re: less competition

Interesting. This from the primary author of the PII study in L/R MDS, one so intimately familiar with Imetelstat and of course a world authority on myelodysplastic syndromes. He correctly laments the inability of current treatments to prolong life in HR MDS. Those of us who as non oncologists try t...
by biopearl123
Tue Jan 30, 2024 8:09 pm
Forum: ImetelChat
Topic: I may be naive (oh, really)
Replies: 1
Views: 986

I may be naive (oh, really)

I may be naive but I view the upcoming ADCOM meeting as a positive (the market doesn’t seem to). This will provide a forum for not only a transparent review of the data, but an opportunity to hear from, well, just about anyone. You can be sure that list will include patients, their families, physici...
by biopearl123
Tue Jan 30, 2024 3:53 pm
Forum: ImetelChat
Topic: Official 8k notice of ODAC advisory meeting
Replies: 4
Views: 1366

Re: Official 8k notice of ODAC advisory meeting

I guess we have trustworthy confirmation now! Thanks for posting.
by biopearl123
Tue Jan 30, 2024 3:51 pm
Forum: ImetelChat
Topic: March 14th
Replies: 4
Views: 1608

Re: March 14th

Works loud and clear, thanks for posting KT.
by biopearl123
Tue Jan 30, 2024 5:36 am
Forum: ImetelChat
Topic: AML study
Replies: 1
Views: 992

AML study

AML study PII results will probably not be known until a scientific meeting. ASCO is usually May/June and EHA is June 13th. Abstracts public about a month before. EHA very close to PDUFA date. In the meantime a buyout/partnership conceivably could occur. Don’t make fun of me. :)
by biopearl123
Tue Jan 30, 2024 1:26 am
Forum: ImetelChat
Topic: March 14th
Replies: 4
Views: 1608

Re: March 14th

I too have seen the March date mentioned but only by completely unreliable sources. We did see a KOL lecturer make general mention of an April date for ADCOM but I have seen nothing concrete. As of now until we see something trustworthy, ADCOM will probably be in April with anticipated approval the ...
by biopearl123
Sat Jan 27, 2024 5:24 pm
Forum: ImetelChat
Topic: Dana-Faber shenanigans.......
Replies: 3
Views: 1960

Re: Dana-Faber shenanigans.......

Kmall, from the sublime to the ridiculous: https://www.ncbi.nlm.nih.gov/books/NBK519803/box/box001/?report=objectonly#:~:text=The%20research%20had%20major%20implications,technicians%20quickly%20discovered%20the%20fraud. I was a second or third year medical student when this amazing bold barf worthy ...
by biopearl123
Thu Jan 25, 2024 3:10 pm
Forum: ImetelChat
Topic: A new Irish Trader? Hat tip to Paul C
Replies: 17
Views: 6350

Re: A new Irish Trader? Hat tip to Paul C

Thanks for posting this RC, definitely a little more detailed and “produced” (music etc.) and a beaming patient who seemed very grateful. Nonetheless devoid of actual detailed patient experience. We still have to wait for that but probably not too much longer. Lots of Cheshire Cat in the Lane group,...
by biopearl123
Tue Jan 23, 2024 6:40 pm
Forum: ImetelChat
Topic: FDA Boxed Warning for CAR-T
Replies: 2
Views: 1344

Re: FDA Boxed Warning for CAR-T

Yes FDA watching carefully. This warning for possible T cell cancers. No indication of such for Imetelstat but with such disordered genetics and “selection” of resistant clones in advanced disease you can be sure they will be watching.
by biopearl123
Mon Jan 22, 2024 7:16 am
Forum: ImetelChat
Topic: Interesting Continuing Education item
Replies: 4
Views: 1378

Re: Interesting Continuing Education item

You have not taken too many medical tests I guess. When there is no other right answers but enrollment in a trial is an option, that’s usually it. The drug trial is still enrolling and would offer this hypothetical patient the best approach.Totally legit test question.