Search found 1670 matches
- Fri Dec 22, 2023 4:39 am
- Forum: ImetelChat
- Topic: 2023 - What a Long, Strange Trip it’s Been
- Replies: 3
- Views: 2812
Re: 2023 - What a Long, Strange Trip it’s Been
HI and Ryan, I agree. Highly doubtful we will see Imet 2.0 before the end of the year. Another over promise and under deliver, Yes, John, you did say by the end of the year. I have to wonder (again) if the envelope between the intentional and unintentional is breached with intent or just irrational ...
- Thu Dec 21, 2023 11:01 am
- Forum: ImetelChat
- Topic: Kaz yet again keep them coming
- Replies: 2
- Views: 1241
Kaz yet again keep them coming
Many thanks:
youtu.be/Dlv2jcS3bQ4?si=CtmFzwLzsuX41n5Y
https://m.youtube.com/watch?si=CtmFzwLz ... e=youtu.be
youtu.be/Dlv2jcS3bQ4?si=CtmFzwLzsuX41n5Y
https://m.youtube.com/watch?si=CtmFzwLz ... e=youtu.be
- Wed Dec 20, 2023 6:20 pm
- Forum: ImetelChat
- Topic: CKTC
- Replies: 2
- Views: 2919
CKTC
Been thinking about your last post. Here’ MAIA with an “elegant” drug with advantages at least in theory over Imetelstat and significant human assets like Sergei M. Gryaznov and Jerry Shay both of whom were once part of Geron. And yet… And yet, they seem to be way behind in clinical development and ...
- Wed Dec 20, 2023 5:14 pm
- Forum: ImetelChat
- Topic: Putting 6-thio-Dg into perspective
- Replies: 15
- Views: 14606
Re: Putting 6-thio-Dg into perspective
CKTC, thanks as always for posting. I do wonder if the lag time for Imetelstat is much less of an issue with AML since the cell doubling time is measured in hours. Also the “non canonical” effects of Imetelstat, now known to be related to ferroptosis effects might be at play. Of course the subtext o...
- Sun Dec 17, 2023 6:16 pm
- Forum: ImetelChat
- Topic: Hat tip again to Kaz YMB
- Replies: 1
- Views: 4756
Hat tip again to Kaz YMB
https://www.youtube.com/watch?v=EfI-CqCMubw https://www.youtube.com/watch?v=EfI-CqCMubw Rami says ADCOM in April Other salient feature, Grade 3-4 neutropenia in 68 % (manageable and transient) but notably only 1% with febrile neutropenia. It’s a stretch and a guess but regarding the need for hospita...
- Fri Dec 15, 2023 1:43 am
- Forum: ImetelChat
- Topic: something to attend
- Replies: 2
- Views: 5775
Re: something to attend
Great dig, hope some on board can listen in and report back.
- Thu Dec 14, 2023 10:00 pm
- Forum: ImetelChat
- Topic: Has anyone seen any onc videos post ASH
- Replies: 4
- Views: 8141
Re: Has anyone seen any onc videos post ASH
Ah, thanks RC, missed reviewing them.
- Thu Dec 14, 2023 8:21 pm
- Forum: ImetelChat
- Topic: Has anyone seen any onc videos post ASH
- Replies: 4
- Views: 8141
Re: Has anyone seen any onc videos post ASH
https://www.youtube.com/watch?v=yglG0-C-1TY
Hat tip to Kaz, YMB. “Dismayed and surprised at the lack of QOL improvement with Luspatercept” in contrast to Imetelstat.
Hat tip to Kaz, YMB. “Dismayed and surprised at the lack of QOL improvement with Luspatercept” in contrast to Imetelstat.
- Thu Dec 14, 2023 7:43 pm
- Forum: ImetelChat
- Topic: Has anyone seen any onc videos post ASH
- Replies: 4
- Views: 8141
Has anyone seen any onc videos post ASH
Has anyone seen any comments besides the X comments kindly referenced by RC? Usually there is a bunch of video interviews, articles post ASH. So far I have not seen much. Please post if you have. Thansk
- Tue Dec 12, 2023 7:54 pm
- Forum: ImetelChat
- Topic: Please
- Replies: 1
- Views: 3754
Please
give it a rest. I will start to limit unnecessarily repetitive posts.
- Tue Dec 12, 2023 6:33 pm
- Forum: ImetelChat
- Topic: About two weeks
- Replies: 4
- Views: 9253
About two weeks
Dr. S has a little over 2 weeks to keep his promise to update re oral agent development progress
- Tue Dec 12, 2023 5:10 pm
- Forum: ImetelChat
- Topic: ADCOM
- Replies: 96
- Views: 294122
Re: ADCOM
LWS, give it a rest. I will start to limit unnecessarily repetitive posts.
- Tue Dec 12, 2023 3:56 am
- Forum: ImetelChat
- Topic: Adverse effects
- Replies: 8
- Views: 11363
Re: Adverse effects
We would have known last month if Geron were granted the honor of a plenary
- Tue Dec 12, 2023 1:02 am
- Forum: ImetelChat
- Topic: Adverse effects
- Replies: 8
- Views: 11363
Re: Adverse effects
You are not wrong, it did not.
- Mon Dec 11, 2023 6:02 pm
- Forum: ImetelChat
- Topic: Adverse effects
- Replies: 8
- Views: 11363
Re: Adverse effects
True. Bluebird’s box warning was related to the risk of emergence of rare cancers. Fortunately, the grade 3 and 4 events with Imetelstat were not and appear to be reversible.
- Mon Dec 11, 2023 4:48 pm
- Forum: ImetelChat
- Topic: Adverse effects
- Replies: 8
- Views: 11363
Adverse effects
There has been some discussion and concern re grade 3 and 4 events which apparently were reversible and did not result in patient deaths. It appears however that the placebo group was also subject to these events although not all were cytopenic events. Will be interesting to hear about how many pati...
- Mon Dec 11, 2023 4:19 am
- Forum: ImetelChat
- Topic: ASH - twitter
- Replies: 10
- Views: 12910
Re: ASH - twitter
RC, thanks for posting this. Undoubted we will hear more. We should keep in mind that TI is a pretty high bar and just reducing the transfusion requirement albeit not to zero is an accomplishment. The rise of hemoglobin of 5 gms in many is important to keep in mind.
- Fri Dec 08, 2023 7:04 am
- Forum: ImetelChat
- Topic: Dr. Patnaik, editorial comment in Lancet
- Replies: 10
- Views: 17758
Re: Dr. Patnaik, editorial comment in Lancet
KT, thanks for your comments. I am actually ok with Dr. P’s editorial. He is after all an expert and was chosen perhaps because of the ties of the early Imet clinical heme studies to Mayo and Dr. T but undoubtedly also because of his experience, expertise and familiarity with Imetelstat (Mayo probab...
- Thu Dec 07, 2023 11:23 pm
- Forum: ImetelChat
- Topic: Dr. Patnaik, editorial comment in Lancet
- Replies: 10
- Views: 17758
Re: Dr. Patnaik, editorial comment in Lancet
KT, I am defending no one but just making an observation. Dr. P has 52 pages of article cited on Pub Med going back over 20 years. It’s hard to find a prominent physician especially in academics that doesn’t have some tie to industry. After all that’s (with the exception of pure funding from foundat...
- Thu Dec 07, 2023 4:02 pm
- Forum: ImetelChat
- Topic: Following CRISPR et. al.
- Replies: 0
- Views: 8290