Search found 202 matches
- Fri Feb 22, 2019 10:03 pm
- Forum: ImetelChat
- Topic: The JNJ-ARGX deal in MDS/AML
- Replies: 1
- Views: 1985
The JNJ-ARGX deal in MDS/AML
is there anyone who has looked at the ARGX MDS trial that doesn't think that this is why JNJ dropped imet? https://www.argenx.com/en-GB/news-internal/argenx-provides-detailed-data-from-phase-2-clinical-trial-of-efgartigimod-in-immune-thrombocytopenia-and-phase-12-clinical-trial-of-cusatuzumab-in-acu...
- Mon Feb 18, 2019 9:10 pm
- Forum: ImetelChat
- Topic: Far from a straight line but still on course
- Replies: 8
- Views: 5114
Re: Far from a straight line but still on course
>"Obviously, there has been a major loss of trust in JNJ/Janssen, Geron, the FDA, the SEC, etc." Exactly. >"our primary means of voicing constructive thoughts are via emails / phone calls to Geron IR and/or written correspondence to the BoD and possibly a comment or question at the annual shareholde...
- Wed Jan 09, 2019 6:47 pm
- Forum: ImetelChat
- Topic: So, WHICH CRO is deciding GERN's future?
- Replies: 0
- Views: 2314
So, WHICH CRO is deciding GERN's future?
Does anyone have any idea when we will know: Which CRO is actually going to attempt the task of recruiting for the MDS trial? (To ask patients to not take any other treatment, to use a drug dropped by big pharma, and to take the 1/3, worse than Russian Roulette, chance of dying on placebo? Seriously...
- Tue Dec 04, 2018 3:57 pm
- Forum: ImetelChat
- Topic: Here are the slides from Dr. Mascarenhas presentation on MF
- Replies: 2
- Views: 2859
Re: Here are the slides from Dr. Mascarenhas presentation on MF
Good results. And Scarlett's reaction is to announce that there will be no action on MF until the end of Q3 2019!
So as always, we're more bullish than the CEO... which makes no sense at all. Things can't go better for a company than the company's own plans, only worse.
So as always, we're more bullish than the CEO... which makes no sense at all. Things can't go better for a company than the company's own plans, only worse.
- Mon Nov 26, 2018 7:27 pm
- Forum: ImetelChat
- Topic: compassionate use program?
- Replies: 9
- Views: 6693
Re: compassionate use program?
bp, JNJ did in fact say that the compassionate-use listing was a mistake. And they DID take it off the list BEFORE the discontinuation decision... to our eternal disgrace (and that of our ancestors and descendants), we all ignored that blatantly obvious sign.
- Mon Nov 26, 2018 7:24 pm
- Forum: ImetelChat
- Topic: Phase III?
- Replies: 5
- Views: 4760
Re: Phase III?
Ryan, I'm sorry for your pain... mine at least ended at $2.30 ;) Geron is not "working on the MDS study". They are hiring people to supervise a clinical-trial subcontracting company sometime after the middle of 2019. Yes, the preclinical from 2016 is fascinating. So are the results of preclinicals i...
- Thu Nov 22, 2018 4:00 pm
- Forum: ImetelChat
- Topic: Phase III?
- Replies: 5
- Views: 4760
Re: Phase III?
Janssen hasn't transferred the trials to GERN yet because GERN doesn't exist. They have to hire people even to supervise the new trial subcontractor. The process is going to take almost a year according to Scarlett's lackadaisical timeline. Scarlett says there won't be a Phase 3 trial until after mi...
- Wed Oct 31, 2018 2:58 pm
- Forum: ImetelChat
- Topic: clinical update (edited for correction on address)
- Replies: 1
- Views: 2664
Re: clinical update (edited for correction on address)
This has been discussed on SA and YMB. Someone emailed CG Capital and they said that Janssen is still mentioned "because they still have responsibility for the trial".
So apparently Geron is going to leave the fake connection to Janssen up until Janssen sues them to take it off.
So apparently Geron is going to leave the fake connection to Janssen up until Janssen sues them to take it off.
- Thu Oct 04, 2018 9:22 pm
- Forum: ImetelChat
- Topic: Abstracts
- Replies: 4
- Views: 3749
Re: Abstracts
the up-front cost to JNJ for ARWR is trivial. They didn't drop imet because they didn't have the cash, they dropped it because they didn't see it working well enough.
- Thu Sep 27, 2018 5:39 pm
- Forum: ImetelChat
- Topic: Lessons learned
- Replies: 1
- Views: 2233
Lessons learned
I've always complained that the "drug-development system" is no such thing. And this is a great example.... TI drugs work, but between the patent system and the monotherapy FDA trial system, they may never get into use inside the US. Those who attacked me as a "basher" for years,...
- Mon Sep 10, 2018 8:45 pm
- Forum: ImetelChat
- Topic: Geron can continue to provide a key part of the equation
- Replies: 18
- Views: 19199
Re: Geron can continue to provide a key part of the equation
Geron has been out of the picture since Scarlett closed the labs all those years ago. Sergei Gryzanov was "Geron"... Scarlett is an absentee, over-retirement-age, patent troll. The sooner JNJ buys GERN patents, the sooner the quest for other TI drugs can start... at least two classes of wh...
- Mon Sep 10, 2018 8:42 pm
- Forum: ImetelChat
- Topic: Why I have left the SA Board
- Replies: 1
- Views: 2548
Re: Why I have left the SA Board
Piketty has been debunked by many serious researchers. He's just clickbait. If you want to worry about something (something that creates inequality), worry about those who get to print themselves money. It's the simple problem that has plagued all modern economies. Here's one of the dozens of Pikett...
- Wed Aug 15, 2018 9:49 pm
- Forum: ImetelChat
- Topic: EMA discussion
- Replies: 4
- Views: 5565
Re: EMA discussion
Sand, "Anne" has been notifying us of imminent EMA approval for years now
...and maybe someday she'll be right. But right now we don't even know if Janssen has applied for anything.
...and maybe someday she'll be right. But right now we don't even know if Janssen has applied for anything.
- Wed Aug 15, 2018 9:46 pm
- Forum: ImetelChat
- Topic: Look for the Continuation Decision next week
- Replies: 3
- Views: 5231
Re: Look for the Continuation Decision next week
I looked and I looked but I couldn't find the CD
...is JNJ actually going to sit on this until Sept 28th?
...is JNJ actually going to sit on this until Sept 28th?
- Wed Aug 15, 2018 9:44 pm
- Forum: ImetelChat
- Topic: New Patent / IMET 2.0 ?
- Replies: 3
- Views: 4103
Re: New Patent / IMET 2.0 ?
This "new" patent was filed as a provisional by Sergei back in 2011.
You can read several papers on these modified G TIs on the Shay web site.
There is also this possibility for Imet 2.0:
https://www.ncbi.nlm.nih.gov/pubmed/26479411
...and everyone has known about these possibilities for years... except, apparently, JNJ
You can read several papers on these modified G TIs on the Shay web site.
There is also this possibility for Imet 2.0:
https://www.ncbi.nlm.nih.gov/pubmed/26479411
...and everyone has known about these possibilities for years... except, apparently, JNJ
- Mon Jul 30, 2018 6:16 pm
- Forum: ImetelChat
- Topic: An excellent article by Hoosier Investor on SA
- Replies: 7
- Views: 12039
Re: An excellent article by Hoosier Investor on SA
Hoosier has presented a very good summary of the possible upside scenarios.
Of course that means he will now be struck down by an unexplainably improbable concentration of cosmic rays. Farewell, Hoosier.
Of course that means he will now be struck down by an unexplainably improbable concentration of cosmic rays. Farewell, Hoosier.
- Wed Jun 13, 2018 4:50 pm
- Forum: ImetelChat
- Topic: Goodbye
- Replies: 9
- Views: 13361
Re: Goodbye
RIP Fish. Too bad he never had access to imetelstat.
- Fri May 25, 2018 5:29 pm
- Forum: ImetelChat
- Topic: Imetelstat....real life story
- Replies: 3
- Views: 8868
Re: Imetelstat....real life story
Uh, didn't we hear that "John" DIED a long time ago?
- Mon Oct 23, 2017 10:09 pm
- Forum: ImetelChat
- Topic: Geron patent published: Method for identification of sensitivity of a patient to telomerase inhibition therapy
- Replies: 2
- Views: 2409
Re: Geron patent published: Method for identification of sensitivity of a patient to telomerase inhibition therapy
I don't think this patent will apply to any therapeutic use of imet. Real-world therapies will always be combinations, so the issue of resistance to imet will be avoided. This is a good thing for imet's possible clinical use, of course.... the patent aims to limit the applicable patient population b...
- Sun Feb 26, 2017 12:33 am
- Forum: ImetelChat
- Topic: Dormant study revived?
- Replies: 6
- Views: 5132
Re: Dormant study revived?
Thanks for doing the legwork there Fish.