hunting, have you checked out the MAIA startup? They're working on 6-thio-dG, the chemical favored by Dr. Shay in some 2015-2016 papers.
https://maiabiotech.com/our-pipeline/thio/
Search found 202 matches
- Thu Nov 21, 2019 4:06 pm
- Forum: ImetelChat
- Topic: So many blind spots right out in the open…
- Replies: 8
- Views: 7370
- Thu Nov 21, 2019 4:04 pm
- Forum: ImetelChat
- Topic: So many blind spots right out in the open…
- Replies: 8
- Views: 7370
Re: So many blind spots right out in the open…
Dr. Rizo didn't "come to Geron". She left Janssen, presumably because she knew the imet project was shutting down, and went to CELG. Then Geron was forced to hire her as it had no one qualified to run a trial. There is nothing negative about that, but nothing positive either. She simply didn't have ...
- Thu Oct 17, 2019 11:31 pm
- Forum: ImetelChat
- Topic: yet another paper shows that we need longer telomeres
- Replies: 1
- Views: 2438
yet another paper shows that we need longer telomeres
Even for cancer prevention, and even in animals that don't turn off telomerase!
https://phys.org/news/2019-10-mice-born ... omeres.amp
Prevention trumps palliatives.
https://phys.org/news/2019-10-mice-born ... omeres.amp
Prevention trumps palliatives.
- Thu Jul 25, 2019 9:02 pm
- Forum: ImetelChat
- Topic: +Seems almost impolite to speak of here
- Replies: 2
- Views: 3273
Re: +Seems almost impolite to speak of here
How darest thou sully the purity of the Cult with thine shameless seeking after mere food, shelter, and medical insurance! Only the highest of the high-born mayest have the honour of sacrificing their inheritance and substance into Geron. Begone before the Great Old One Rises for the next Call Of Ch...
- Mon Jun 10, 2019 11:21 pm
- Forum: ImetelChat
- Topic: Signs of life in MF on the 25th?
- Replies: 0
- Views: 3562
- Fri Jun 07, 2019 7:52 pm
- Forum: ImetelChat
- Topic: Report from Annual Meeting by Bridge from SA
- Replies: 0
- Views: 3276
Report from Annual Meeting by Bridge from SA
https://seekingalpha.com/instablog/2368 ... veryone-go
Bridge confirms that GERN is withholding the Mayo data. Also that they are doing no work on improving imet or imet delivery systems.
Bridge confirms that GERN is withholding the Mayo data. Also that they are doing no work on improving imet or imet delivery systems.
- Fri Jun 07, 2019 7:50 pm
- Forum: ImetelChat
- Topic: Dr. Shay's update on telomerase inhibitor 6-thio-G
- Replies: 6
- Views: 5517
Re: Dr. Shay's update on telomerase inhibitor 6-thio-G
Yes, the priests were horrified when smallpox vaccine let some children "unnaturally" live to adulthood, and they've moaned at every advance since. (Read about Ethan Allan's fight with the clergy on vaccination...) Since I was immortalizing cells with vectors in 2001, I think you're a little out of ...
- Mon Jun 03, 2019 2:53 pm
- Forum: ImetelChat
- Topic: Dr. Shay's update on telomerase inhibitor 6-thio-G
- Replies: 6
- Views: 5517
Re: Dr. Shay's update on telomerase inhibitor 6-thio-G
Kara, Geron actually has at least one patent relating to 6-thio-G... this is just another issue that makes people who follow GERN lose SAN points. The specific MOAs of imet and 6-thio-G are very different, maybe they could be used in combo? With all the GERN patents, why is Scarlett constantly tryin...
- Thu May 30, 2019 2:43 pm
- Forum: ImetelChat
- Topic: The difference between "may suggest" and "indicates"
- Replies: 6
- Views: 5809
Re: The difference between "may suggest" and "indicates"
>"MF may get approved based on historical data." Yes, that has always been a major hope here (maybe the principal hope, given the competition and timeline in MDS). But it can't happen before the company at least talks to the FDA in 2020. There is plenty of time to order a short oligo from a commerci...
- Thu May 30, 2019 2:35 pm
- Forum: ImetelChat
- Topic: An end run...
- Replies: 2
- Views: 3287
Re: An end run...
I agree, this is somewhat encouraging. They probably don't have useful historical controls right now because of the differences between different hospitals' protocols and generally bad databases (HIPAA didn't help the already-backwards hospital medical databases). But that doesn't that the necessary...
- Thu May 30, 2019 2:32 pm
- Forum: ImetelChat
- Topic: how to get full text papers through sci-hub
- Replies: 0
- Views: 3365
how to get full text papers through sci-hub
I keep seeing posts on YHOO and Seeking Alpha from people that "can't get full text of X paper", or even "I can't post the abstract to this paper".
Sci-hub solved these problems long ago, here's the link:
https://whereisscihub.now.sh/
Sci-hub solved these problems long ago, here's the link:
https://whereisscihub.now.sh/
- Tue May 21, 2019 2:43 pm
- Forum: ImetelChat
- Topic: The difference between "may suggest" and "indicates"
- Replies: 6
- Views: 5809
Re: The difference between "may suggest" and "indicates"
The issue with Janssen as an imetelstat supplier is cost, not quantity. Any commercial supplier would give a better deal (kind of nasty of Janssen to charge high prices for their stockpile of a drug that they are just discarding anyway, but there it is). Again, it's the medical organization "EHA", n...
- Tue May 21, 2019 2:35 pm
- Forum: ImetelChat
- Topic: Dr. Shay's update on telomerase inhibitor 6-thio-G
- Replies: 6
- Views: 5517
Re: Dr. Shay's update on telomerase inhibitor 6-thio-G
So has anyone here read this?
You can bet that JNJ read the 2015 papers.
You can bet that JNJ read the 2015 papers.
- Tue May 14, 2019 3:56 pm
- Forum: ImetelChat
- Topic: May 16th it is - Yet Another Day of Anticipation
- Replies: 10
- Views: 7457
Re: May 16th it is - Yet Another Day of Anticipation
It's the EHA, not the EMA. One tries to cure heme diseases, the other protects pharma cartel profits... try to keep them straight ;) Yes, this is the best-case scenario. IF the abstract suggests durable effectiveness, and IF we hear from Rizo instead of having the entire presentation in stuttervisio...
- Fri May 10, 2019 4:49 pm
- Forum: ImetelChat
- Topic: Dr. Shay's update on telomerase inhibitor 6-thio-G
- Replies: 6
- Views: 5517
- Thu May 02, 2019 10:43 pm
- Forum: ImetelChat
- Topic: Shareholder’s letter
- Replies: 14
- Views: 7043
Re: Shareholder’s letter
kara, neither of the Phase 2 trials have placebo arms IIRC. They are using "historical controls", which are very poor as different hospitals keep records differently and the patient groups may not be comparable. The MF trial does have some comparison available between the two dose arms, as the low-d...
- Tue Apr 30, 2019 8:21 pm
- Forum: ImetelChat
- Topic: What makes a CEO a CEO?
- Replies: 16
- Views: 9834
Re: What makes a CEO a CEO?
I'm all in favor of market-based CEO compensation. I remember the hilarity that ensued when Ben&Jerry tried to hire a "CEO" for one-tenth the market rate (they ended up paying the market rate after all, big surprise). But that doesn't mean that stockholders can just go to sleep while a long-term CEO...
- Mon Apr 29, 2019 11:26 pm
- Forum: ImetelChat
- Topic: The odds of Phase 3 success in oncology
- Replies: 0
- Views: 3070
The odds of Phase 3 success in oncology
This is a bit premature, but this is a 2018 paper on Phase 3 success rates broken down by category: https://academic.oup.com/biostatistics/article/20/2/273/4817524 Obviously Geron has some special factors (e.g. the large number of previous failed trials), but at least knowing the average success rat...
- Mon Apr 29, 2019 4:13 pm
- Forum: ImetelChat
- Topic: What makes a CEO a CEO?
- Replies: 16
- Views: 9834
Re: What makes a CEO a CEO?
Thanks Smuggie, interesting stuff... I would have expected options to work better as incentives, at least on CEOs that are below retirement age and still have active lifespan remaining. The good news at GERN, if there is any, is that the Janssen crew knows more about the MOA than anyone else. That d...
- Fri Apr 26, 2019 9:02 pm
- Forum: ImetelChat
- Topic: ? Can Geron proceed to a P3 w/o JnJ data
- Replies: 4
- Views: 4289