Search found 367 matches

by biopearl
Fri Jun 29, 2018 6:02 pm
Forum: ImetelChat
Topic: Clinical trial site update today MDS study
Replies: 0
Views: 3152

Clinical trial site update today MDS study

The Clinical trials site has been updated to reflect a 4 month extension of the anticipated conclusion of the MDS study. Since the extra 25 patients have completed enrollment in Feb I believe this extension signals a firm plan to proceed to part two of the phase III study. bp
by biopearl
Thu Jun 28, 2018 10:23 pm
Forum: ImetelChat
Topic: So when does common sense and morality come into play?
Replies: 1
Views: 3042

Re: So when does common sense and morality come into play?

Nicely said Hunt, I think it is a good summary of the frustrations patients are feeling as they wait. And wait. Clearly the FDA was not willing to approve on the basis of the Dr. Tefferi studies or even the ET studies. In some ways waiting for a critical juncture is strategic-- the longer we wait th...
by biopearl
Tue Jun 26, 2018 4:52 pm
Forum: ImetelChat
Topic: New Geron slide set on home page
Replies: 2
Views: 3063

Re: New Geron slide set on home page

Also note "exploratory" indications. This could mean anything. Solid tumors for example. bp
by biopearl
Tue Jun 26, 2018 4:51 pm
Forum: ImetelChat
Topic: New Geron slide set on home page
Replies: 2
Views: 3063

Re: New Geron slide set on home page

The writing is on the wall for those who wish to read it. Toward the end of the presentation is a clear indication of future plans. ("if" continuation decision.) AML phase II/III, MF Phase III. MDS phase III. Re the reference to MF phase III: Scarlet has said that there are no plans within the rubri...
by biopearl
Tue Jun 26, 2018 3:57 pm
Forum: ImetelChat
Topic: New Geron slide set on home page
Replies: 2
Views: 3063

New Geron slide set on home page

This reflects recent data presented at EHA:

http://ir.geron.com/static-files/0c553e ... 2c8870b371
by biopearl
Mon Jun 25, 2018 8:14 pm
Forum: ImetelChat
Topic: Looking at EHA presentation a little more closely
Replies: 4
Views: 5788

Re: Looking at EHA presentation a little more closely

Ucj, it is my pleasure. I hope we can get an active vibrant board going. Greg, thank you for responding, if indeed we are looking at this correctly and I think we are, taken as a whole if only two patients did not respond at all and one patient got worse we are looking at over a 90% response rate. G...
by biopearl
Sun Jun 24, 2018 8:59 pm
Forum: ImetelChat
Topic: Article ref form taz
Replies: 1
Views: 1992

Re: Article ref form taz

It appears that the MF pts in this study are not end stage advanced cases so results may not be comparable toJanssen study. The future possility of combinations remains intriguing bp
by biopearl
Sun Jun 24, 2018 4:33 pm
Forum: ImetelChat
Topic: Article ref form taz
Replies: 1
Views: 1992

Article ref form taz

https://onlinelibrary.wiley.com/doi/ful ... /cam4.1619

Combo of rux and interferon with some remissions. Will do a close read and try to comment when I can but I thought I would at lease post the reference so folks can start reading and commenting. bp
by biopearl
Sun Jun 24, 2018 1:24 am
Forum: ImetelChat
Topic: More on the EHA presentation re marrow recovery
Replies: 2
Views: 3070

Re: More on the EHA presentation re marrow recovery

I will look through my Dr.T notes but I think you are right. bp
by biopearl
Sun Jun 24, 2018 1:22 am
Forum: ImetelChat
Topic: Sdraw epic thesis
Replies: 1
Views: 2063

Re: Sdraw epic thesis

Dogonenuts, Sdraw thoughts have been incredibly perspicacious. He did give permission for reposting (hint). Since the Imbark study collected data on the last patient on April 26th and since the FDA previously requested data from Janssen 6 or 7 months previously, I am thinking it’s possible the FDA a...
by biopearl
Fri Jun 22, 2018 5:52 pm
Forum: ImetelChat
Topic: More on the EHA presentation re marrow recovery
Replies: 2
Views: 3070

More on the EHA presentation re marrow recovery

To my knowledge, CRs, PRs etc have not been previously described in MDS or MF, of this magnitude, is anyone aware of this occurring anywhere else? (I think Jakosa tried to make the case for JAKFI but I don't remember particulars and if anything there wasn't much of a comparison, correct me if I don'...
by biopearl
Fri Jun 22, 2018 4:37 pm
Forum: ImetelChat
Topic: Looking at EHA presentation a little more closely
Replies: 4
Views: 5788

Looking at EHA presentation a little more closely

Good Day to all from your board moderator, biopearl. New members please don't forget to register or you can not post. Please do post and foster relevant discussions. Posts must be pertinent and avoid ad hominem attacks. A few thoughts on the EHA presentation. I have not actually heard the presentati...
by biopearl
Wed Jun 13, 2018 9:39 pm
Forum: ImetelChat
Topic: Goodbye
Replies: 9
Views: 13295

Re: Goodbye

Fish Jr., As you can see there are already many views on this site. You may not be aware that your Dad also posted on Seeking Alpha. I am including a link so you can see the comments made by those who will miss "Fish". I hope you have been able to read my notes to you and that we can move to a priva...
by biopearl
Wed Jun 13, 2018 7:48 pm
Forum: ImetelChat
Topic: Goodbye
Replies: 9
Views: 13295

Re: Goodbye

Fish asked me to keep his medical condition confidential when he asked me to co moderate the Imetelchat board, and so I did. Now that his son "Fish Jr" has announced Fish's passing I think we can all extend to Fish's son our appreciation for the very high quality board his father established and fos...
by biopearl
Wed Jun 13, 2018 3:18 pm
Forum: ImetelChat
Topic: To Fish Junior
Replies: 0
Views: 2797

To Fish Junior

Alex, First off you should know how greatly appreciated yours father's work on this board and his personal insights were valued by many. As to the future of this board, please know that I would like to communicate privately with you in this regard. The kind note you sent me had an invalid email addr...
by biopearl
Fri Jun 08, 2018 10:11 pm
Forum: ImetelChat
Topic: Sdraw
Replies: 3
Views: 7479

Sdraw

Few posters has the scientific background or the willingness to educate that Sdraw does. I wish he would post here but I am unable to approve new posters even though I function as a moderator of sorts so instead I will for now be more of a triage agent and post links. Here is a link to Sdraws tweets...
by biopearl
Fri May 25, 2018 5:46 pm
Forum: ImetelChat
Topic: Imetelstat....real life story
Replies: 3
Views: 8859

Re: Imetelstat....real life story

Jingle, what you have posted is very relevant in terms of history but is unfortunately not current. I was honored to communicate directly with Irish for a few years while John was receiving therapy at Mayo. His progress was remarkable and he did go from advanced disease to CR/PR status. Unfortunatel...
by biopearl
Fri May 25, 2018 4:11 am
Forum: ImetelChat
Topic: Geron is setting the stage to raise capital, a lot of it.
Replies: 0
Views: 3459

Geron is setting the stage to raise capital, a lot of it.

I was asked privately to comment on this. I completely missed the ATM sale pointed out by phil but not this time, no one can. While some have suggested Geron needs the money because J and J plans to walk and Geron will have to "go it alone", something fearless JS says he would do with no hesitation,...