ImetelChat

Bio, You bring up an interesting point about Irish, and effect on longevity. Hopefully for John's sake, he's still receiving benefit from treatment and doing well. But assuming that's not the case, didn't he still achieve great results and a longer period of symptom free disease than generally accep...

The following is an excerpt from the abstract mentioned above: This review summarizes new patents published on telomerase inhibitors from 2010 to 2015. Expert opinion：The review provides a brief account of the background, development, and on-going issues involving telomerase inhibitors. In particula...

Thanks for submitting these questions to Geron; they're crafted very well, and hopefully Dr. Scarlett will respond.

Great posts. I have emailed Geron a couple times re MM trials, and not received any response, not surprised. The following is posted on the Geron Website re May 17, 2016 call: Geron stockholders accessing the annual meeting by telephone will be invited to ask a question during the question and answe...

Sorry if this was brought up previously. An abstract was issued recently entitled "Telomerase inhibitors: a patent review (2010-2015.)" at PubMed.gov. Does anyone have access to the full text? Looks very interesting. Second, Sergei Gryaznov and Krisztina Pngracz filed patent app # 20150322438 on 11....

Hoosier Investor wrote a great article on SA Jan 12, 2016 entitled "Geron:What To Expect From Imetelstat Now." It's worth reviewing because it was written before the recent changes to the MM clinical trial. Interesting because the article spends a good amount of discussion on Multiple Myeloma, refer...

Bio, thanks for pointing this out. So the study is complete as of November, 2014. On March 14, 2016 the study is changed to Imetelstat alone or in combination with lenalidomide standard of care maintenance therapy. Also added is a lower dosing of 7.5 mg/kg as a 2-hour intravenous infusion. It would ...

re. cheng_ho "Might I suggest that the first thing to look at is how many other telomerase inhibitors are covered, if any? The antisense oligos are only a tiny part of the available inhibitor chemicals." Well that's really the big question isn't it? And if I were looking for an answer to this questi...

Fisher, If you go to diva-portal.org and search using the title of abstract you will be able to download the entire paper.

I think hoosierinvestor was one of the patent experts.

biopearl: I read this as a direct reference to enhancing imetelstat. I didn't read it that way. I think the author's statement is a reference to enhancing telomerase inhibition in general. In his paper, part IV, he discusses Imetelstat and the desire to test it against his inhibitor. (This paper is ...

Thanks Fisher. My understanding (limited) is the author discusses some of the benefits of an unmodified oligonucleotide vs Imetelstat, using a different mechanism for getting to its target. It would be great to hear from someone that can explain in laymen's terms. Also, would be interesting to have ...

Hello, Wondering if this has been discussed before, and if someone could comment on the research outlined in this abstract/paper. Would not this be something Jannsen/Geron must be working on behind the scenes? Sorry, I don't have a link, but you can find the abstract by searching the following: Nove...

Is there a way to send someone a pm? I think this board has potential to become the go to site for Imetelstat/Geron. Thank you Fisher for setting this up.