ImetelChat

As if Dr. Scarlett hasn't been obscure enough over the years... How is the board interpreting this language? As examples: 1. We know Jakafi failures don't live long. 2. We know Imetelstat can result in CR and PRs but we don't know if true in R/R patients. 2. We know the preliminary data in MDS mirro...

Sdraw's observations have always been well considered and grounded. Thanks for sharing them. Fish this is a question for you. Do you remember reading in prior 10K's, updates on some patient deaths early in the study? These were expected given the severity of disease and the late stage that therapy w...

Just for interest, the doubling time for MOLM-13 cells is 50 hours. 77 days and 40 % survival suggests a wipe out of CSC's. Cheng where are you and do you think that could possibly be correct? bp

77 days is an unusual number of days to arbitrarily stop a study and almost surely reflects the deadline required for study completion and submission of the abstract. This of course means on April 3rd additional data can be presented that I hope will include more up to date additional mouse longevit...

New abstract has been release from embargo. I am sure Fish will post. Results very interesting. Combo resulted in significant apoptosis in vitro and significant life extension in 40% of mice 77 days after therapy stopped. I would love to know how many if any of the 40% survivors showed evidence for ...

Fish saw your note about asking Anna about the new abstract. I would not expect her to respond. All we have in the public domaine is a title with no actual abstract until later today. At that point we might get some comment as part of todays Q4 2016 summary from Dr. S. He is confined to the "four co...

Fish, let me add my thanks to hunt's comments regarding the quality of this board, the service, research and courtesy you have extended us. I would add only a couple of things. One is that I think there is enough information to infer that IMbark will stop after the Q2 review. I believe at that point...

Fish, thanks for looking into this. Wish the CT site was impeccably reliable. It is unfortunately not. bp

Fish, my read is that a funding source was found apparently external to J and J. Whether they are contemplating actually doing the study now is of course unknown or whether some modification e.g. combo might move forward. I don't think its confidential, just that it might be non company sponsored. bp

Was reviewing the very interesting presentation from the Lane group at ASH. They engrafted AML cells in mice and tested imetelstat. In responders (60%) the survival was a dramatic 50% at 300 days (p<.0001). This was not a combo study so I think we will see something pretty dramatic in the abstract r...

Anne S on ymb has noted the old study looking at imet in pediatric patients that was"withdrawn" before enrolling any one and sat on Ct site for years has had some inscrutable changes as os feb 8th. Fish maybe you can ask Anna as regrettably she no longer answers my emails. Bp

Did not. No sense of humor. bp

I did, just not when it first occurred to me. bp

Here is a note I meant to send to Anna earlier when the new web site came out. Hi Anna, I have a dispassionate observation to share about the new website. It certainly is an improvement and conveys the company message well, except for one thing. The horse. So, the rocking horse is a childs toy and t...

PTCA thanks for pointing out that the full text of the currently embargoed abstract will be available March 1st at 4:30. And we still have the European heme meetings and ASCO way before ASH to look forward to. Best wishes bp

Nice find. "in vivo"! must be in mice but it looks like they picked their combo agent. bp

Fish, thanks for your excellent post. Anna's explanation is clearer that others I have read. I like many have no problem waiting if positive adjustments to the long term plan are based on as yet unevaluated results. I do object to Scarlett dangling the AML study as planed or even likely for 2016 and...

Hi Irish, thanks for your note and kind words. Yes I remember the "is Irish real" controversy well. But I knew you were because of your sincerity, defending you was easy for that reason alone and I was amazed at how many unkind people were posting awfulness to a family with a member with cancer. I h...

By the way four years is extraordinary especially given John original prognosis. I think the reason this is all taking so darn long is that J and J will provide clear longevity data, the longer the better. bp

Hi Irish, Thanks for the update. Wonderful to hear John (and you) are doing well. There must be some other patients in the imetelstat fraternal order that you run into on infusion days, can you let us know how any of them are doing? Oh, and Sargasso, you can play poker with me anytime, be sure to br...