ImetelChat

Fisher, right now if you have pancreatic cancer etc. you face absolutely certain death. It is ridiculous to pretend that we are "helping" patients by forcing them to die in approved ways :mrgreen: The underlying issue is simple... do you own your own bloodstream, or do the "important people" who are...

Not sure how this could fit into Chip's and Huh's schedules... they need to be working on the affairs of CTMX and CHMA, companies that still have operations

Absolutely correct that current "right to try" laws are just symbolic. The problem is that sick and old people are sick and old, it's hard to organize them for effective action... perhaps we need a "Dalek" line of more aggressively designed wheelchairs. Some state reps in NH are pushing for an expli...

"Right to try" laws have been passed in many states (including NH) that give doctors of terminally ill patients the right to use ANY drug that is even in Phase I.

Why are these tert promoters in the leukemia cells methylated? In the bulk of genomic DNA, most CpG sites are heavily methylated while CpG islands (sites of CpG clusters) in germ-line tissues and located near promoters of normal somatic cells, remain unmethylated, thus allowing gene expression to oc...

Nice find.

If anyone finds the best links on the EMA site for following imet's status, please post... that might make a good sticky for this board. That and a thread keeping track of all trial enrollment numbers.

OT, does anyone know anything about TAM-818, or the status of Sierra?

Blood cancers are a big space by themselves... but we still need a way to inhibit telomerase in solid tumors.

Anne posted this on the new YMB (Marissa is clearly shorting YHOO, the board is unusable): From Draft COMP Agenda 11-13 July 2016 Imetelstat sodium - EMA/OD/154/15 Janssen-Cilag International N.V.; Treatment of primary myelofibrosis COMP coordinator: Frauke Naumann-Winter Following review of the app...

There was a thread about this on the YMB... it looks like Marissa killed the YMBs. Maybe we'll see some of the reasonable posters here.

Anyway, there was supposed to be a committee action yesterday or today.

Another reason why a buyout sooner than later makes sense, to use as much of the losses as possible before they expire!

Inflation makes them "expire" anyway, but the seven-year limit is even more urgent.

Looks interesting... now if only I could get full-text without driving 10 miles and sneaking into the med library (in 2016!) I'm all for keeping expenses down, but if we're going to blow billions on research every year it would be nice to spend a few more million so that the taxpayers could actually...

We need to change the whole system and make the medical industry more like the computer industry. It is criminal for terminally ill patients to be denied the right to try new therapies. It come down to this: do WE own our selves, or does the FDA/Pharma complex? http://www.strike-the-root.com/51/walk...

They just threw Immunogenics out for trying to present old data... how is GERN allowed to?

To do a good job would take a full time staff

Might I suggest that the first thing to look at is how many other telomerase inhibitors are covered, if any? The antisense oligos are only a tiny part of the available inhibitor chemicals.

A poster I don't remember encountering before (Cheng_Ho) burst on the YMB scene today Well, I've been posting with the rest of the yahoos at least since 2003, but it's understandable that you wouldn't notice... the YMB is filled with messages, but not with information. In fact, I've been posting si...