Search found 210 matches

by biopearl123
Thu Sep 06, 2018 6:08 am
Forum: ImetelChat
Topic: New review article
Replies: 2
Views: 1409

New review article

file:///C:/Users/arkie/Downloads/molecules-23-02267%20(4).pdf
Review
Oligonucleotides Targeting Telomeres and
Telomerase in Cancer

Hat tip, fear this raptor and hay flick
by biopearl123
Thu Aug 30, 2018 4:21 am
Forum: ImetelChat
Topic: Upcoming Catalysts
Replies: 5
Views: 7332

Re: Upcoming Catalysts

An upcoming presentation here too (again provided by the good egis of MTB: http://soho2018.org/program/
by biopearl123
Wed Aug 29, 2018 11:16 pm
Forum: ImetelChat
Topic: Upcoming Catalysts
Replies: 5
Views: 7332

Re: Upcoming Catalysts

Small addition: Sept 4th, FBR panel on heme disease both Dr. Scarlett and Dr. Raza in this session. Link (hat tip to MTB): http://www.meetmax.com
by biopearl123
Tue Aug 28, 2018 9:38 pm
Forum: ImetelChat
Topic: An appeal from biopearl
Replies: 3
Views: 1703

Re: An appeal from biopearl

jpheis, many thanks. Fish Jr reads this board regularly. I will ask him to contact you directly. I am intentionally not dealing with any finances except as they pertain to the management of this board and my own personal donations. Your support and kindness is greatly appreciated. bp
by biopearl123
Tue Aug 28, 2018 6:30 am
Forum: ImetelChat
Topic: Going out on a limb
Replies: 0
Views: 1517

Going out on a limb

I posted this as part of a private interaction with a well respected poster. I am just putting it out there, admittedly based on not much. Ok, so my MF thesis is that mod/high risk patients not infrequently develop AML and this is one significant modus exodus. This is of course why they get classifi...
by biopearl123
Sun Aug 26, 2018 7:31 pm
Forum: ImetelChat
Topic: Do NOT sell
Replies: 10
Views: 6894

Re: Do NOT sell

Hi Phil, thanks for posting. I couldn't agree more with your assessment. EU approval has been telegraphed. There are a few mysteries worth examining. The GC's sale is not one of them for all the reasons you enumerate. Scarlett has acted as if he remained uncertain about the CD, but of course he knew...
by biopearl123
Fri Aug 24, 2018 4:08 pm
Forum: ImetelChat
Topic: Do NOT sell
Replies: 10
Views: 6894

Re: Do NOT sell

Phil, thank you. Your track record is pretty pretty good (to quote Larry David). It does look like there is a lot of interest in Europe. Interestingly the job posting at Janssen does not mention MF but emphasizes MDS and AML (!) in patients not eligible for induction. Perhaps MF approval is a forgon...
by biopearl123
Fri Aug 24, 2018 12:08 am
Forum: ImetelChat
Topic: An appeal from biopearl
Replies: 3
Views: 1703

Re: An appeal from biopearl

Part II: Sergei of course was the true father of Imetelstat. He apparently made a soft landing at Janssen so I won't include him on this list as he is not strictly now an academic but I think we will hear much more about him in the coming months. His contribution and brilliance is enormous as are hi...
by biopearl123
Thu Aug 23, 2018 11:53 pm
Forum: ImetelChat
Topic: An appeal from biopearl
Replies: 3
Views: 1703

An appeal from biopearl

As some of you know from private communications, I have been retired for about 6 weeks which has provided me with ample time for reflection. It has been my pleasure to moderate this board and I was truly honored when Fish Sr. asked me to take this on. It is hardly onerous as virtually all contributo...
by biopearl123
Thu Aug 23, 2018 9:34 pm
Forum: ImetelChat
Topic: Ongoing Trial Updates
Replies: 6
Views: 2576

Re: Ongoing Trial Updates

J6, I have interpreted this a little differently and (perhaps less optimistically.). As I recall, GRN1005 was based a a vehicle that permeated the blood brain barrier and was hoped to allow easier entry for an Imetelstat conjugation into the CNS. After evaluation the license was returned to the (I t...
by biopearl123
Wed Aug 22, 2018 3:56 pm
Forum: ImetelChat
Topic: Cool, I'm finally part of the family!
Replies: 7
Views: 1610

Re: Cool, I'm finally part of the family!

MTB, we are very fortunate to have you here, thank you for joining. Sorry for the bumps in the road. We can thank Fish Jr. for getting the registration process straightened out. I hope things will be easier now for you and all other board members going forward. bp
by biopearl123
Tue Aug 21, 2018 1:02 am
Forum: ImetelChat
Topic: Ongoing Trial Updates
Replies: 6
Views: 2576

Re: Ongoing Trial Updates

J6, very nice find. I haven’t looked at the GRN1005 study for years and yet there are all 49 (!!!) updates. Geron said the FDA would look at the totality of the data and I guess they are sure lookin’! Interesting that the study has changed from a therapeutic study to a diagnostic one. bp
by biopearl123
Mon Aug 20, 2018 2:43 am
Forum: ImetelChat
Topic: Just read a Fishermagnets post from 1/11/2016
Replies: 2
Views: 1077

Re: Just read a Fishermagnets post from 1/11/2016

Nuts, I am not one for conspiracy theories, but whatever happened it is unlikely the FDA will withstand the weight of Janssen as opposed to the days when Geron was going it alone. When the curious hold happened it was a "partial" hold not a "complete" hold so some patients contin...
by biopearl123
Sun Aug 19, 2018 1:53 am
Forum: ImetelChat
Topic: New article in Blood re Jak inhibitors and lymphoid malignancy
Replies: 4
Views: 1415

Re: New article in Blood re Jak inhibitors and lymphoid malignancy

Nuts, agreed, you will get no argument from me. JAK inhibitors reduce spleen size but do not appear to prolong life once one gets to the R/R stage, in fact by definition, therapy with JAK inhibitors does not help this group. So as with many therapies, symptom improvement comes with a price, includin...
by biopearl123
Sat Aug 18, 2018 6:52 am
Forum: ImetelChat
Topic: New article in Blood re Jak inhibitors and lymphoid malignancy
Replies: 4
Views: 1415

New article in Blood re Jak inhibitors and lymphoid malignancy

Here's the reference: No mention of Imetelstat in article or references. Mainly describes possible increased risk of lymphoma (B-cell) and JAK inhibition.

http://www.bloodjournal.org/content/132 ... ecked=true
by biopearl123
Fri Aug 17, 2018 4:25 pm
Forum: ImetelChat
Topic: Blood Journal Article “How I Treat MF after failure of Jak inhibitor tx
Replies: 1
Views: 879

Re: Blood Journal Article “How I Treat MF after failure of Jak inhibitor tx

dongonenuts, Here's the reference, its an open article and is readily accessible, Dr T is one of the authors. I think we have discussed it before and ideally I would like to provide access via the library but as you know that's a work in progress! Regards, bp How I treat myelofibrosis after failure ...
by biopearl123
Fri Aug 17, 2018 1:48 am
Forum: ImetelChat
Topic: New Patent / IMET 2.0 ?
Replies: 3
Views: 1921

Re: New Patent / IMET 2.0 ?

J6, thank you for posting. This patent as Cheng points out was provisional but now as you have kindly posted appears to have been issued. Note the provision for oral administration. As yet we know nothing about potential synergism in vivo but it sure is interesting. Again thank you for your research...
by biopearl123
Fri Aug 17, 2018 1:43 am
Forum: ImetelChat
Topic: Look for the Continuation Decision next week
Replies: 3
Views: 2394

Re: Look for the Continuation Decision next week

Cheng, Very funny, very funny. I looked too and couldn't find it, must just be looking in the wrong place (or the wrong time). bp
by biopearl123
Sat Aug 04, 2018 8:22 pm
Forum: ImetelChat
Topic: A quick read from the Shay/Wright Lab
Replies: 0
Views: 1394

A quick read from the Shay/Wright Lab

Hat tip to PEDMAC2000 YMB: this is from the Shay Wright lab and is current:
https://www.utsouthwestern.edu/labs/sha ... erase.html
by biopearl123
Wed Aug 01, 2018 8:24 pm
Forum: ImetelChat
Topic: Housekeeping notice
Replies: 2
Views: 1338

Housekeeping notice

It looks like several new members are here. Welcome. Just a note and a reminder. 1. If you choose an offensive user name, you will not be approved. 2. If your email looks like a bot (we have learned...) don't bother, you will not be approved. The vast majority of posters are posting thoughtful contr...