Search found 1665 matches

by biopearl123
Tue Dec 05, 2023 5:48 am
Forum: ImetelChat
Topic: Dr. Patnaik, editorial comment in Lancet
Replies: 10
Views: 17689

Dr. Patnaik, editorial comment in Lancet

Like every major featured article in a top tier medical journal, a prominent physician is asked to comment. I did "buy" 24 hour access to the comments by Dr. Patnaik of the Mayo in Rochester. I am sure I had to agree not to reproduce it so I will just summarize a few points. Dr. Patnaik summarized t...
by biopearl123
Mon Dec 04, 2023 6:45 pm
Forum: ImetelChat
Topic: things have a way of coming full circle
Replies: 6
Views: 8792

Re: things have a way of coming full circle

Ryan, I did not mean to cast doubt on your ability or anyone else’s to appreciate the current presentation of the Imetelstat data. I was merely sharing my own reaction to my first subscription to the NEJM as a first year, first day 22 year old medical student. No aspersions or judgements were meant ...
by biopearl123
Mon Dec 04, 2023 4:01 pm
Forum: ImetelChat
Topic: things have a way of coming full circle
Replies: 6
Views: 8792

Re: things have a way of coming full circle

As far as I am concerned “tantamount to a cure” has been discredited as was a product of irrational exuberance. Bigger that all of us was an interesting choice of words over a decade ago and didn’t materialize. There is however a very underserved area of heme onc that will benefit from Imetelstat. L...
by biopearl123
Mon Dec 04, 2023 2:43 am
Forum: ImetelChat
Topic: things have a way of coming full circle
Replies: 6
Views: 8792

things have a way of coming full circle

The commentary that accompanies the Lancet article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02187-6/fulltext# takes us back to the Mayo Clinic in Rochester Minn. I hope Dr. Tefferi is able to find some satisfaction in seeing a close colleague of his bring further recogniti...
by biopearl123
Mon Dec 04, 2023 2:26 am
Forum: ImetelChat
Topic: twitter
Replies: 11
Views: 13747

Re: twitter

Ryan, thank you for posting (I don’t read twitter (X) on GPs), it can’t be said that we are normal people. We have been studying this company and this drug for a long time. Pretty sure by now most regulars could breeze through the Lancet article just fine. If we were “normal” we would have walked or...
by biopearl123
Sat Dec 02, 2023 8:44 pm
Forum: ImetelChat
Topic: Lancet, hat tip to Omar
Replies: 4
Views: 6734

Re: Lancet, hat tip to Omar

When I was a medical student lo those many centuries ago, the Dean of the medical school told us on the first day of classes to all get a subscription to the New England Journal of Medicine. We dutifully did. It was terrible advice for first day, first year med students. The journal was completely u...
by biopearl123
Fri Dec 01, 2023 10:35 pm
Forum: ImetelChat
Topic: 2 year anniversary.......
Replies: 2
Views: 4028

Re: 2 year anniversary.......

The answer to that question is long and would take up an entire blank page.
by biopearl123
Fri Dec 01, 2023 9:37 pm
Forum: ImetelChat
Topic: Cancer vaccine
Replies: 6
Views: 10688

Re: Cancer vaccine

Ross929, The cancer vaccine program went to what is now LCTX. Near as I can tell that company is not doing well and the LAMP technology is outdated and probably not too effective if at all. Your reference is almost 20 years old and has no relevance to today’s Geron other than an old agreement that G...
by biopearl123
Wed Nov 29, 2023 4:02 pm
Forum: ImetelChat
Topic: FDA and CAR-T
Replies: 1
Views: 3101

Re: FDA and CAR-T

CAR-T much harder to adopt to MDS/MF, points we have discussed previously:

https://www.youtube.com/watch?v=lFLr1mKhsds
by biopearl123
Tue Nov 28, 2023 8:32 pm
Forum: ImetelChat
Topic: New Board Member
Replies: 9
Views: 9090

Re: New Board Member

To Kmall’s point about “independence”:

https://www.skadden.com/insights/public ... t-director
by biopearl123
Tue Nov 28, 2023 5:42 pm
Forum: ImetelChat
Topic: New Board Member
Replies: 9
Views: 9090

Re: New Board Member

Hunt, Wow, right you are. At least he knows the company.
by biopearl123
Tue Nov 28, 2023 4:19 pm
Forum: ImetelChat
Topic: New Board Member
Replies: 9
Views: 9090

Re: New Board Member

Yes Jay, it seems that we have a long and fluid catalogue of board members with experience in buy outs. Not too much time left in 2023 for JS to make good on two promises. 1. Acknowledge 50% enrollment in MF study and 2. Update on oral agent progress. Post ASH updates themselves will probably not in...
by biopearl123
Tue Nov 28, 2023 3:42 am
Forum: ImetelChat
Topic: Bayer is taking a bath......
Replies: 2
Views: 5843

Re: Bayer is taking a bath......

I’ve noticed some basic science ferroptosis articles coming out of Germany…
by biopearl123
Fri Nov 24, 2023 4:56 am
Forum: ImetelChat
Topic: Giving Thanks.......
Replies: 2
Views: 5576

Re: Giving Thanks.......

Kmall, well said. Have lost so many family to cancer, it’s a good time to reflect and hope for the future.
by biopearl123
Wed Nov 22, 2023 5:19 pm
Forum: ImetelChat
Topic: Bridge
Replies: 0
Views: 8396

Bridge

Bridge, thanks for trying to contact me re new Geron patent filing. The PM function on chat can be unwieldy. Will check my private emails as I think you have that address. In any case if it’s an Imet/Venclexa combo it is almost certainly related to AML (we love you Aussies!!).
by biopearl123
Tue Nov 21, 2023 7:04 pm
Forum: ImetelChat
Topic: Top Geron Clinician Goes To Vividion Therapeutics.....
Replies: 29
Views: 55353

Re: Top Geron Clinician Goes To Vividion Therapeutics.....

Kmall, I should have been more specific, I meant their Bayer options! Sorry.
by biopearl123
Tue Nov 21, 2023 6:00 pm
Forum: ImetelChat
Topic: Top Geron Clinician Goes To Vividion Therapeutics.....
Replies: 29
Views: 55353

Re: Top Geron Clinician Goes To Vividion Therapeutics.....

Wonder if their incentive options took a hit