ImetelChat

From my simplistic view, all the negative feedback is based mostly on historical price action and mushrooms from there against the company, management, strategy and even the science, but all seems to rely on price action as the feeder into the FUD. Without that I doubt we would see so much negativit...

Thanks, sargasso, it’s nice you can state those constructive thoughts on ImetelChat without any need for spin or worry about being harassed by those with dishonest intentions. It’s not like we don’t know what they are up to with these sinister and lame comments. They always seem to increase in numbe...

Fishermanagents, I for one have admired and greatly appreciated your ability and willingness to confront those on the YMB and SA that do not have the success of Imetelstat and Geron or the patients in mind. I hope you are able to continue doing that as people do need to understand what these people ...

I agree with you Fishermanagents, a lot of chess is being played here and I suspect the market shorts will be checkmated in the near future and have to move to a different venue to play their board games. Just wanted to say that I marvel at the information you provide and shepherd here on ImetelChat...

Thanks, Fishermanagents, that’s what I thought. Either way, I don’t think all the new MF patients (I think it’s something like 3000/year) could be covered by CT’s so it must have just been a comment he hoped would get back to the FDA / EMA, etc. to make the argument that they need to get this proces...

Dr. T., as Anonymous Wizard pointed out again today on SA, is on record as encouraging MF patients to look to CT’s for treatments versus Jakafi. Since he didn’t specifically mention Imetelstat by name (maybe due to legal considerations) could his statements include drugs in CT’s besides Imetelstat? ...

Thanks for the info Fishermanagents, it’s easy to see why you are impressed with this drug. Potentially treating fibrosis in areas beyond bone marrow and pulmonary conditions was a surprise to me as well. Would be interesting to know if PRM-151 has any R/R issues like Jakifi or other palliative MF t...

Fishermanagents, not sure this is something discuss-able on your site but thank you for your comments and interest in following Promedior, Inc. PRM151 and bringing it to our attention on the SA board. Has this drug has been overlooked by most watching this space or just me? I am relatively new to th...

Again, I am a novice on watching a drug move from a phase I CT through the processes to get to a NDA and eventually a marketable product. What we are observing is understandable to some in the know and / or with experience with the processes. For me and possibly others there is a lot that doesn’t ma...

I would be very interested in knowing the following: 1. Why did JNJ opt to do the MF R/R study first versus frontline and when do you expect the frontline study to begin? 2. Thousands of hemo patients are hoping to have access to Imetelstat, extending the trials is alarming to them. Can you please o...

It would be interesting to know if Dr. Tefferi would be excited about a MF frontline study versus the current R/R study. Referring to his comments in Italy.

Interesting posts occurring on the YMB re: patent trolls and patent inventor Ayalew Tefferi's work. Does this change the landscape on getting Imetelstat to market and investments in Geron or is it just a side consideration? https://www.google.com/patents/US20160287625 Methods and materials for treat...

Thanks for the links Fishermangents, interesting details on the lengthy process. While most, including myself, don’t understand what activities and steps are occurring during the 210 days of review or the 120 if a negative decision is appealed, it helps understand that a marketing application is not...

Thanks, Irishtrader52. This, in my mind at least, is exactly the situation that brings in activitists, professional activists (medical, government, investment, etc.). There is so much at stake here and so many things that are not making simple common sense. Makes me wonder if this chat board could b...

A rhetorical question certainly, as we know the answer is, there is no line unfortunately. Statistics have been shared in various, indicating thousands of people in the US and around the world are suffering (and of course rapidly dying) from MF and many other hemo diseases as well. Many with MF are ...

BP, thanks for your thoughts, much appreciated. Unless I am misunderstanding, I think your points support moving to obtain marketing approval as soon as possible versus expanding the CTs in time, patients, sites, etc. Wouldn’t once approved, “off label” usage and further approvals come relatively qu...

From a purely layman’s perspective, was wondering if I and possibly others, might be underestimating JNJ / Jansen Biotech / Geron’s grand plan here. For example, could they intend to exit the CT’s with the competitive intention of being able to replace all or most drug and surgical options currently...

I have read, don’t remember the source and it has been 2-3 years ago, that Dr. Tefferi is primarily interested in the medicine and the patients with serious hemo diseases and apparently has little, if any interest, in the investment side of it. Based on everything I have seen and read since seems to...

What is Compassionate Drug Use (CDU)? Came across this information on the American Cancer Society website about compassionate drug use. It could be helpful to anyone trying to obtain access to unapproved drugs. The link was: http://www.cancer.org/treatment/treatmentsandsideeffects/clinicaltrials/com...

Thanks Fishermangents for your comments and feedback as always. Your perspective and experience is invaluable. On your question, his doctor indicated he would reach out to Dr. Tefferi on this case. In his last email, he indicated he had still not discussed with Dr. Tefferi but was trying to get that...