ImetelChat

So sorry to hear about your father. He created an incredible space for the discussion of MF and Imetelstat, and his personality came through in his often passionate writing. He'll be missed by many.

Thanks for the response BP. There is so much written on Geron it's difficult to know what's been covered. And much information can be interpreted differently depending on your perspective. From Q4 2017 Geron Earnings Conference Call, Olivia Bloom: "For 2018 we are projecting an operating expense bur...

Thanks BP. Where's Fish? Would like him to weigh in here if possible.

Good Catch!

Sargasso, perhaps you can post your response here. The current Alpha Exposure article is obviously written to accomplish a goal, and I despise it as I do pump pieces that also intentionally hide valuable information that might help to form a balanced view, and thus a more informed investment decisio...

Not sure if this paper is referenced on ImetelChat....Quantitative analysis of imetelstat in plasma with LC–MS/MS using solid-phase or hybridization extraction (12/2017). Interesting to note at least three of the four authors are Janssen/Johnson & Johnson employees. Also interesting to view the 44 p...

Prescient words; always appreciate your knowledge and intuition. You nailed it!

Hi Fish, I thought I'd make a comment regarding the SA site. In my view, your posts are spot on and very well thought out; I've learned a lot from your site and writings. But, and I say this in a spirit of friendship, I believe it's counter-productive to engage with characters such as BM and Imetels...

Agree Fish; If it’s determined for whatever reason(s) that Imetelstat isn’t having much affect on TI but is effective for other reasons, is that a big deal? It seems to me the narrative about Imetelstat has changed slightly over the last few CC's and wondering what your thoughts were. thx

The American Chemical Society recently put out a Top 40 list of Drugs in the Pipeline. Re. Imetelstat, they write: “Intriguingly, the data suggest that the drug is not altering telomerase activity, but instead acting through an alt. cellular mechanism to halt blood cell proliferation.” I recall duri...

Bio, you recently posted on SA some questions for someone to ask at the upcoming CC. I do believe anyone is able to call in and ask questions; perhaps you could do it yourself?

From Magic on SA: From the Yahoo board: Published on 19/07/2016 "Epigenetic landscape of the TERT promoter: a potential biomarker for high risk AML/MDS": Telomerase reverse transcriptase promoter;methylation profile;mutation analysis;acute myeloid leukaemia;survival curve Summary Although recent obs...

Targeting homologous recombination and telomerase in Barrett's adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth. Lu R1, Pal J2, Buon L2, Nanjappa P2, Shi J3, Fulciniti M3, Tai YT3, Guo L4, Yu M4, Gryaznov S5, Munshi NC3, Shammas MA2. Author information: 11] Depart...

Fisher, I think this was already posted, but like re-reading the interview with Dr. Sergei Gryaznov, I find it more stunning the second time. This is, again from last year's EMA PDCO (Pediatric) Minutes for the meeting on July 15-17 dated August 12, 2015 Janssen-Cilag International N.V; Treatment of...

Committee for Orphan Medicinal Products (COMP) Draft agenda for the meeting on 11-13 July 2016 Pre-meeting list of participants and restrictions in relation to declarations of interests applicable to the items of the agenda for the COMP plenary session to be held 11-13 July 2016. See July 2016 COMP ...

Thanks Fisher

Thanks Bio. I think we can be reasonably confident John is still on the 7.5 dosage.

The following was posted on Facebook @ Imet 33: Greg E. 5/18/16 Two other Shareholders and I were able to talk with Dr. Scarlett briefly after the Annual Meeting. As the meeting was now over, Dr. Scarlett said that he would answers questions at this time only if he felt he could. I asked him if he c...

Hunting, I read he was treated with Revlimid, Velcade, and Dexamethasone.

The question I have for the good doctor relates to "what's next" for Imetelstat. Any ideas on how to phrase the question for the best chance of response would be appreciated. I was reviewing an interview of Dr. Gryaznov, former employee of Geron by drkkd.com: "Dr. Gryaznov held the positions of Dire...