ImetelChat

Yeah, I’m getting deeply concerned to be honest. I don’t doubt that imetelstat can still get approval, but it seems like the commercial prospects are shrinking, the wait is still very long, and there won’t be much encouraging news to boost the stock in the meantime. Hard to make an argument that thi...

Is it a lower or higher bar to demonstrate improvement in patients who are treatment refractory? Could be one argument for the study designs to date. At least in my field, if someone comes in with mild symptoms we know they’re a lot less likely to show a big treatment effect. Or maybe its a higher b...

Wouldn’t stopping the cancer proliferation with Imetelstat be worth doing right off the bat, followed by (or concurrent with) symptom management? Or will Constellation’s drug handle that well enough by itself?

Gotcha

bp, are/were you in HMS somewhere? Not trying to dox myself but I work at an affiliated hospital. I’ve thought about using that connection to bug Steensma about Imetelstat but figured it would be completely unprofessional and I’m not even a medical doctor, let alone in heme/onc.