Search found 367 matches

by biopearl
Sat Jul 14, 2018 4:55 pm
Forum: ImetelChat
Topic: CSCs
Replies: 0
Views: 2303

CSCs

Hat tip to "toast" from YMB for this post. (Fish Jr still working on board update so eventually important info such as this can be posted on library page). https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.13084 Tantalizing reminder (discussed on Imetelchat at length in past) of potent...
by biopearl
Sat Jul 14, 2018 12:41 am
Forum: ImetelChat
Topic: New telomerase article
Replies: 8
Views: 4332

Re: New telomerase article

Hoosier's reply to jpheis question (hat tip to Hoosier): Hi BP, The recent S3 filings indicate Geron has sold an additional 9.44M shares since the Q1 Earnings update.....in which they highlighted the separate ~14M in share sales (early-Q2) that raised ~$47M in cash. I expected them to use ~50% of th...
by biopearl
Fri Jul 13, 2018 9:51 pm
Forum: ImetelChat
Topic: Sdraw
Replies: 0
Views: 2052

Sdraw

We are fortunate to have Sdraw's permission to repost from twitter. Again a scholarly and thoughtful analysis. I will just post the link for those interested (oh right that would be everybody). bp

https://twitter.com/_sdrawkcabeman_/sta ... 2640474113
by biopearl
Fri Jul 13, 2018 6:18 pm
Forum: ImetelChat
Topic: Change in Clinical trials low risk primary completion date
Replies: 1
Views: 1660

Re: Change in Clinical trials low risk primary completion date

I should have added that it seems reasonable to conclude with this most recent event that there will be a positive CD. bp
by biopearl
Fri Jul 13, 2018 5:43 pm
Forum: ImetelChat
Topic: Change in Clinical trials low risk primary completion date
Replies: 1
Views: 1660

Change in Clinical trials low risk primary completion date

The Clinical Trials site has changed the anticipated primary study date conclusion from Feb 26, 2021 to Oct 21 2020. Its only four mounts bu its pretty hard to envision Janssen taking the time to make these relative minor modifications if they didn't plan to move to the randomized phase III study. bp
by biopearl
Fri Jul 13, 2018 2:05 am
Forum: ImetelChat
Topic: April 2018 Patent
Replies: 1
Views: 1737

Re: April 2018 Patent

j6proulx, thank you for calling attention to this. I think we are seeing an FDA predilection for approaches that favor "personalized" therapy. One can envision a table of markers that might predict response such as this one re telomere length coupled with IL 8 levels etc. As I recall, telomere lengt...
by biopearl
Fri Jul 13, 2018 1:54 am
Forum: ImetelChat
Topic: New telomerase article
Replies: 8
Views: 4332

Re: New telomerase article

jpheis, thanks for the lead, I am headed there now but would defer to our legal types for clarification. bp
by biopearl
Wed Jul 11, 2018 5:14 pm
Forum: ImetelChat
Topic: Continuation Decision ?
Replies: 2
Views: 2822

Re: Continuation Decision ?

j6, I found the link pretty readily on LinkedIn. Looks current and legit. Thank you
by biopearl
Wed Jul 11, 2018 4:54 pm
Forum: ImetelChat
Topic: Continuation Decision ?
Replies: 2
Views: 2822

Re: Continuation Decision ?

j6prouix, thanks for sharing this, I am certainly willing to review this information privately if you wish, however if information is in the public domaine I believe it can be shared without consequence, its the insider private info that gets people into trouble. And of course if this person inadver...
by biopearl
Wed Jul 11, 2018 4:37 pm
Forum: ImetelChat
Topic: New telomerase article
Replies: 8
Views: 4332

Re: New telomerase article

jpheis, good idea, I will PM Hoosier and see if he is willing to share his thoughts on this board. Re Ed's soliloquy it was great, he is certainly someone searching to understand the big picture, I only wish JS had answered his queries. bp
by biopearl
Wed Jul 11, 2018 3:38 am
Forum: ImetelChat
Topic: General Announcement from bio pearl
Replies: 6
Views: 11541

Re: General Announcement from bio pearl

No apology necessary, I am delighted to see fellow board members on the lookout for the good stuff.
by biopearl
Wed Jul 11, 2018 3:35 am
Forum: ImetelChat
Topic: S3 filing
Replies: 2
Views: 2293

Re: S3 filing

Thank you Ryan, I mistakenly thought this was a new filing. Thanks for clarifying bp
by biopearl
Wed Jul 11, 2018 12:01 am
Forum: ImetelChat
Topic: New telomerase article
Replies: 8
Views: 4332

Re: New telomerase article

Ryan, first off its my pleasure. I want to express my thanks to Fish Jr for his support and for helping me understand how best to do this. And thanks to jpheis (this board) and Richard on YMB for calling this recent study to our attention. Yes, that preclinical study is strong and you make some grea...
by biopearl
Tue Jul 10, 2018 11:54 pm
Forum: ImetelChat
Topic: S3 filing
Replies: 2
Views: 2293

S3 filing

Well today after market our friends at Geron filed an S3 to raise up to 250M additional dollars. Of course speculation will be rampant that this means Geron will be going it alone. If you feel that way lets all take a breath. (I know I need to) and consider: 1. Excellent data presentation at EHA 2. ...
by biopearl
Tue Jul 10, 2018 3:50 pm
Forum: ImetelChat
Topic: General Announcement from bio pearl
Replies: 6
Views: 11541

Re: General Announcement from bio pearl

Thank you jpheis, I actually posted the link yesterday. It is exciting and continues the work of the Yale group. Pretty soon I should be able to figure out a way to actually get this into the library. We are in the process of updating the phpBB site with the necessary upgrades. Regards, bp
by biopearl
Tue Jul 10, 2018 2:33 pm
Forum: ImetelChat
Topic: Expanded Mayo Trial
Replies: 1
Views: 2036

Re: Expanded Mayo Trial

Welcome j6proulx and thank you for sharing your thoughts. After Dr. Tefferi presented his initial 33 or so patients in the NEJM and reported heretofore never seen CR/PR/CIs it was a very exciting time. As you point out the study continue to enroll fairly large numbers to a total of 81. To my knowled...
by biopearl
Tue Jul 10, 2018 2:17 am
Forum: ImetelChat
Topic: New telomerase article
Replies: 8
Views: 4332

New telomerase article

Thought I would post link so we can all start reading and thinking about this one (from the Yale (!) group. We have talked about their very impressive lab findings re combination therapy in the past. I have only skimmed this and plan to spend some time with it in the next day or two. https://bmccanc...
by biopearl
Thu Jul 05, 2018 4:10 pm
Forum: ImetelChat
Topic: Trouble registering?
Replies: 0
Views: 1873

Trouble registering?

I have been notified that some people are having trouble registering via the board link. Lets try this: send me an email (I am getting them from this address): info@imetelstat.eu Include a valid email and your board name. I am now in touch with the phpBB folks and will work to iron out some of these...
by biopearl
Wed Jul 04, 2018 10:48 pm
Forum: ImetelChat
Topic: General Announcement from bio pearl
Replies: 6
Views: 11541

General Announcement from bio pearl

Fellow board members "Fish Jr" has kindly "promoted" me to Global Administrator. I am pleased to see many new members have requested (and been granted) posting privileges. As we approach the continuation agreement with Janssen deadline, I suspect we will have some interesting discussions on this boa...
by biopearl
Fri Jun 29, 2018 7:04 pm
Forum: ImetelChat
Topic: A theory
Replies: 2
Views: 2950

A theory

As noted Clinical trials has prolonged the time for anticipated completion of the MDS study to Feb of 2021 for primary completion and Feb 2022 for total study completion. In light of the very good data presented at EHA and the data as yet unknown to us but presumably confirmatory data in the 25 pati...