Search found 40 matches

by Dogonenuts
Tue Oct 02, 2018 2:57 am
Forum: ImetelChat
Topic: Recent events
Replies: 3
Views: 1839

Re: Recent events

My thoughts. If the ASH data were so good Janssen would have held on. I have no confidence in Scarlett and the board at this point. His statements of derisking the drug were very misleading and I think criminal to an SEC interpretation. I have been in this drug a long time and sold logging a loss th...
by Dogonenuts
Fri Aug 31, 2018 5:05 am
Forum: ImetelChat
Topic: Upcoming Catalysts
Replies: 5
Views: 7332

Re: Upcoming Catalysts

Bio, there are SEVERAL sessions where imet might be mentioned. Hanks for he link!
by Dogonenuts
Sun Aug 26, 2018 11:43 pm
Forum: ImetelChat
Topic: Do NOT sell
Replies: 10
Views: 6889

Re: Do NOT sell

Biopearl, As crazy as it sounds, I wonder if a lot of the questions you pose would not be cleared up were it not for th ASH info embargo. It is really unethical that the surprise value of a medical meeting would come before freeing up a new medication that might save a few lives between now and Dec....
by Dogonenuts
Mon Aug 20, 2018 4:51 am
Forum: ImetelChat
Topic: Just read a Fishermagnets post from 1/11/2016
Replies: 2
Views: 1077

Re: Just read a Fishermagnets post from 1/11/2016

BP I hope you are right in guessing the weight of Janssen vs. Geron. My suspicions at the time were based on the LFT elevations being so meaningless in the oncology world that Geron admitted they did not think them relavent to include in their initial reports. I hope whoever pulled the leverat the t...
by Dogonenuts
Sun Aug 19, 2018 2:44 pm
Forum: ImetelChat
Topic: Just read a Fishermagnets post from 1/11/2016
Replies: 2
Views: 1077

Just read a Fishermagnets post from 1/11/2016

He qoted Irish saying(paraphrased) that she had learned that cancer cures or near cures don’t come easy when there are competing interests. It seems that I am not the only one that thought the fda hold was fraudulent and desugned to give Incy and Celg some time. Why has there not been more made of t...
by Dogonenuts
Sun Aug 19, 2018 3:10 am
Forum: ImetelChat
Topic: New article in Blood re Jak inhibitors and lymphoid malignancy
Replies: 4
Views: 1415

Re: New article in Blood re Jak inhibitors and lymphoid malignancy

When I see articles like this and then consider the revenues the likes of Incyte and Celgene are bringing in for tx that is of very limited value, I have to believe someone was paid off at the FDA for the clinical hold on imet that almost ruined the company and greatly devalued GERN’s market cap. I ...
by Dogonenuts
Sat Aug 18, 2018 9:52 pm
Forum: ImetelChat
Topic: New article in Blood re Jak inhibitors and lymphoid malignancy
Replies: 4
Views: 1415

Re: New article in Blood re Jak inhibitors and lymphoid malignancy

BP, this is a pretty strong arguement for an alternative Tx for MF, MDS and would open the door for first line Tx once approved in the r/r setting. The authors’ demanding further investigation of Jak inhibitors being related to a 16 fold increase in likelihood of developing an aggressive lymphoma is...
by Dogonenuts
Sat Aug 18, 2018 9:51 pm
Forum: ImetelChat
Topic: New article in Blood re Jak inhibitors and lymphoid malignancy
Replies: 4
Views: 1415

Re: New article in Blood re Jak inhibitors and lymphoid malignancy

BP, this is a pretty strong arguement for an alternative Tx for MF, MDS and would open the door for first line Tx once approved in the r/r setting. The authors’ demanding further investigation of Jak inhibitors being related to a 16 fold increase in likelihood of developing an aggressive lymphoma is...
by Dogonenuts
Fri Aug 17, 2018 2:52 pm
Forum: ImetelChat
Topic: Blood Journal Article “How I Treat MF after failure of Jak inhibitor tx
Replies: 1
Views: 879

Blood Journal Article “How I Treat MF after failure of Jak inhibitor tx

There was an interesting article in Bloodjournal.org back in Feb on treating MF patients failing Jak inhibitor tx. Very encouraging for imet prospects. Jak patient dropout and adverse effects noted makes the clinical hold on imet way back when even more fishy. Have no proof, but I would bet someone ...
by Dogonenuts
Fri Jul 20, 2018 1:25 am
Forum: ImetelChat
Topic: FDA Thoughts on Accelerated Approval
Replies: 6
Views: 4321

Re: FDA Thoughts on Accelerated Approval

I would agree, both of these are screeming both Imbark and Imerge! Just a matter of time.

Thanks for posting.
by Dogonenuts
Sat Jun 23, 2018 9:16 pm
Forum: ImetelChat
Topic: Sdraw epic thesis
Replies: 1
Views: 817

Sdraw epic thesis

For those who have not seen it, Sdraw has produced an epic thesis on where imet could go in combination therapies. It is a great tribute to the work Fishermagnets put in on this website over the years which helped many of us retain our sanity while we like salmon have swum continuously upstream wait...
by Dogonenuts
Sat Jun 23, 2018 9:12 pm
Forum: ImetelChat
Topic: More on the EHA presentation re marrow recovery
Replies: 2
Views: 1349

Re: More on the EHA presentation re marrow recovery

I think those bone marrow responses closely mirror the original Mayo study. BP, you probably have those numbers right at hand. This replication of results is of great significance, because, how many times have we seen one great set of results not reproduced in subsequent studies? History shows what ...
by Dogonenuts
Thu Jun 14, 2018 1:38 am
Forum: ImetelChat
Topic: Goodbye
Replies: 9
Views: 4901

Re: Goodbye

Fish Jr. I know how you must feel. The loss of a passionate father leaves a big hole. I appreciate the education many of us got from this message board. It is far more civilized than any other, thanks to your Dad’s diligence. I have a cousin recently diagnosed with MF, so it hits home to me. Hope yo...
by Dogonenuts
Sat Apr 14, 2018 11:51 pm
Forum: ImetelChat
Topic: (08-02-2018) - Janssen BioTech applies for global patent for combo treatment for hematologic cancers, incl imetelstat
Replies: 5
Views: 5033

Re: (08-02-2018) - Janssen BioTech applies for global patent for combo treatment for hematologic cancers, incl imetelsta

Fish and some of you more knowledgeable give me your thoughts here. My credentials are that I am an old MD, not a hematolgist, and I hated biochem, microbiology amd genetics in med school, but I do understand some of this stuff and Lord knows I have seen plenty of people with cancer in my practice o...
by Dogonenuts
Mon Apr 09, 2018 8:59 pm
Forum: ImetelChat
Topic: Reply to the short sellers
Replies: 1
Views: 1221

Re: Reply to the short sellers

More and more I feel we will see Imet as first line Tx, as discontinuation rate of Jakafi is pretty high.
by Dogonenuts
Wed Mar 28, 2018 5:46 pm
Forum: ImetelChat
Topic: Link to recent article on pancreatic cancer cell lines
Replies: 2
Views: 1447

Re: Link to recent article on pancreatic cancer cell lines

Some pretty heavy reading, but my if imet in combo with a parp could give pancreatic CA a good push back, now that would be huge. Pancreatic and glioblastoma are the final frontiers in oncology.
by Dogonenuts
Tue Mar 27, 2018 9:54 pm
Forum: ImetelChat
Topic: Needham conference
Replies: 1
Views: 919

Re: Needham conference

It is available from the IR portal on the Geron site.
by Dogonenuts
Tue Mar 27, 2018 8:49 pm
Forum: ImetelChat
Topic: Needham conference
Replies: 1
Views: 919

Needham conference

Can we listen to the webcast?