Search found 202 matches
- Thu Feb 29, 2024 2:35 pm
- Forum: ImetelChat
- Topic: The science just changed, we didn't understand telomere replication
- Replies: 0
- Views: 1133
The science just changed, we didn't understand telomere replication
Just in from Rockefeller paper, everything we know is wrong. We had the very basics of DNA replication wrong. Big implications for Imetelstat. I don't see any problem for 6-thio-dG, but would like to hear any ideas on it. https://www.rockefeller.edu/news/35439-double-trouble-at-chromosome-ends/#:~:t...
- Sun Dec 10, 2023 4:40 pm
- Forum: ImetelChat
- Topic: The latest from MAIA-- THIO-101 works
- Replies: 0
- Views: 5707
The latest from MAIA-- THIO-101 works
Latest presentation from MAIA. This is bigger than PCYC... getting in at this level will let everyone recover their GERN losses and more. Happy Holidaze everyone!
https://www.channelchek.com/videos/maia ... n19-replay
https://www.channelchek.com/videos/maia ... n19-replay
- Wed Sep 27, 2023 3:07 pm
- Forum: ImetelChat
- Topic: Good Book On the FDA/Pharma Process
- Replies: 0
- Views: 10738
Good Book On the FDA/Pharma Process
"For Blood And Money" by Vardi. Covers the insanity behind the PCYC buyout and drug approval. Apparently it helps to have a deranged Scientologist running the company... one wonders when one of our genius billionaires will realize that the FDA "system" is killing them along with us peons...
- Wed Sep 27, 2023 3:02 pm
- Forum: ImetelChat
- Topic: ADCOM
- Replies: 96
- Views: 295734
Re: ADCOM
ADCOMs do not "shorten timelines". They can kill the drug, but there is no mechanism to speed things up. That's not how FDA works.
- Wed Aug 23, 2023 3:13 am
- Forum: ImetelChat
- Topic: FDA accepts NDA
- Replies: 19
- Views: 9724
Re: FDA accepts NDA
(?) The FDA rejected priority review for Imetelstat... EVEN THOUGH WE HAD FAST TRACK!
This is how they kill biotechs... just delay delay delay.
18,000 FDA employees, and they can't do priority review for Fast Track drug? Absurd.
This is how they kill biotechs... just delay delay delay.
18,000 FDA employees, and they can't do priority review for Fast Track drug? Absurd.
- Mon Dec 19, 2022 2:52 am
- Forum: ImetelChat
- Topic: Everyone is a little edgy
- Replies: 20
- Views: 11275
Re: Everyone is a little edgy
Thanks for your recent posts, kmall, you make some good points. However, you can't stick with your "Bill iS a rEpTile aLiEN" stuff unless you actually believe that I have time travel tech... I have posted the subjects of op-eds and scientific papers on YHOO BEFORE THEY WERE PUBLISHED many times over...
- Sat Dec 03, 2022 9:47 pm
- Forum: ImetelChat
- Topic: For YMB readers:
- Replies: 2
- Views: 1293
Re: For YMB readers:
Thanks. This poster doesn't seem to back up any SF3B1 limitations... in fact, it doesn't seem useful for further genetic targeting at all, which is unfortunate. Hopefully there is better data from the Phase 3.
- Tue Jul 26, 2022 7:55 pm
- Forum: ImetelChat
- Topic: MAIA's telomerase inhibitor now in Phase 2
- Replies: 1
- Views: 938
- Tue Jul 12, 2022 9:07 pm
- Forum: ImetelChat
- Topic: Geron has had an employee at Bayer since 2014
- Replies: 6
- Views: 2262
Re: Geron has had an employee at Bayer since 2014
Thanks for the employee list, kmall.
Imetelstat is RNA, it binds to the hTR RNA, not to proteins.
Imetelstat is RNA, it binds to the hTR RNA, not to proteins.
- Thu Jul 07, 2022 4:38 am
- Forum: ImetelChat
- Topic: Just a question
- Replies: 6
- Views: 2216
Re: Just a question
My understanding is that they shouldn't have to do a Phase 1, since Imetelstat has repeatedly been studied for safety.
As bp says, anything can be prescribed off-label (half of prescriptions are), but it's useful to have approvals in more specific indications.
As bp says, anything can be prescribed off-label (half of prescriptions are), but it's useful to have approvals in more specific indications.
- Sat Apr 09, 2022 8:14 pm
- Forum: ImetelChat
- Topic: There are many ways to think about partnering
- Replies: 177
- Views: 372498
Re: There are many ways to think about partnering
There is NO chance of partnering before Phase 3 results. No one dilutes their stock @$1.05 during a news drought if there were ANY chance of a partnership announcement to drive up the price and allow dilution at a better price.
Geron is going it alone at least until 2023.
Geron is going it alone at least until 2023.
- Sat Jan 08, 2022 7:45 pm
- Forum: ImetelChat
- Topic: The ATM Beast of Baluchistan in the room
- Replies: 10
- Views: 3730
The ATM Beast of Baluchistan in the room
So, the shorts think GERN is going to succeed, their covering has been the main force holding up the stock price since Dec 2020. But the CEO doesn't agree... he just keeps selling ATM shares near 52-week lows, according to the last report. If Phase 3 data is as good as Phase 2, why in the world is h...
- Wed Dec 08, 2021 6:37 pm
- Forum: ImetelChat
- Topic: "We could have skimped and watched our pennies but....
- Replies: 6
- Views: 3240
Re: "We could have skimped and watched our pennies but....
Meanwhile, the only real research talent from the old days (Sergei Gryzanov) went to MAIA, not to Geron.
And the non-working Geron "staff" remain in Foster City. Biotechs that brag about not watching pennies, while selling ATM shares for pennies, aren't looking out for their investors.
And the non-working Geron "staff" remain in Foster City. Biotechs that brag about not watching pennies, while selling ATM shares for pennies, aren't looking out for their investors.
- Fri Nov 26, 2021 7:12 pm
- Forum: ImetelChat
- Topic: Thoughts on IMET2.0 toxicity improvements...
- Replies: 2
- Views: 1457
Re: Thoughts on IMET2.0 toxicity improvements...
If they use antibody-labeled liposomes to target the oligo (e.g. the original GRN 163) on cancer cells instead of dumping most of it into off-target cells, there would clearly be a MASSIVE decrease in toxicity. But there won't be an "oral imetelstat"... MAIA's 6-thio-dG is oral, but that's because i...
- Fri Nov 26, 2021 7:06 pm
- Forum: ImetelChat
- Topic: Have we come full circle? Cheng Ho’s fondest dream
- Replies: 4
- Views: 2315
Re: Have we come full circle? Cheng Ho’s fondest dream
Don't forget Ms. Dikmun's return, she's now on the MAIA science board.
- Sat Nov 13, 2021 11:59 pm
- Forum: ImetelChat
- Topic: A Few Random Thoughts re Recent Conference
- Replies: 6
- Views: 2641
Re: A Few Random Thoughts re Recent Conference
Yes, they screened a lot of compounds looking for telomerase activators, and found the astragalus chemical that became TA-65. However, one million is a tiny subset of the organic chemicals, and Nature herself already has activators more powerful than TA-65, e.g. Centella asiatica herb: https://www.n...
- Sat Nov 13, 2021 11:53 pm
- Forum: ImetelChat
- Topic: ILAP timeline
- Replies: 3
- Views: 1931
Re: ILAP timeline
All of which would have been VERY appropriate for Scarlett to bring up at the Investor Conference.
Instead, he evaded mentioning ILAP even in passing. Why?
Instead, he evaded mentioning ILAP even in passing. Why?
- Sat Nov 13, 2021 11:46 pm
- Forum: ImetelChat
- Topic: ymb deleter
- Replies: 2
- Views: 1550
Re: ymb deleter
Both Kmall and Martin have bragged on YHOO about "reporting" any posts that contain information about Geron that they don't want others to know. Obviously Early Retirement/jkokao/Julie/etc. does the same. We really need to use other forums, YHOO's software itself deletes most posts with reference li...
- Sat Nov 13, 2021 11:35 pm
- Forum: ImetelChat
- Topic: Old Geron vs. New Geron
- Replies: 2
- Views: 1393
Old Geron vs. New Geron
The AML combo trial is great news. News that we should have had in 2016, at least with the azacitidine arm. IMO both the Venetoclax and azacitidine arms will show massive increase in efficacy over imet monotherapy. Both because of synergy in promoting apoptosis and because it will be MUCH harder for...
- Mon Sep 13, 2021 5:05 pm
- Forum: ImetelChat
- Topic: 2.0?
- Replies: 5
- Views: 2721
Re: 2.0?
rinconj, Geron was forced by the Janssen deal to shut down its lab... they don't have one. Now, repackaging the old imet into a less obsolete form for oilgo delivery is easy... but then it would have to start approval all over. There ARE many other companies using telomerase inhibitors, many combo t...