Search found 144 matches

by cheng_ho
Fri Sep 04, 2020 6:39 pm
Forum: ImetelChat
Topic: Orphan being discussed AML/MDS/JMML
Replies: 9
Views: 1237

Re: Orphan being discussed AML/MDS/JMML

What they're discussing is waiving the pediatric testing requirement, as you'll remember was done for the Phase 2.

This is a very good thing, it will speed up the trial... and as biopearl points out, incidence in children is super rare.
by cheng_ho
Tue Sep 01, 2020 9:00 pm
Forum: ImetelChat
Topic: New telomerase-inhibitor company MAIA has new paper
Replies: 0
Views: 321

New telomerase-inhibitor company MAIA has new paper

Paper on MAIA's telomerase-inhibitor drug 6-thiodG coming out this month:

https://www.businesswire.com/news/home/ ... ncouraging
by cheng_ho
Tue Sep 01, 2020 8:59 pm
Forum: ImetelChat
Topic: Current job listing
Replies: 3
Views: 531

Re: Current job listing

No, please stop. Geron doesn't have a lab, they aren't doing any preclinicals of their own.
by cheng_ho
Thu Aug 27, 2020 5:40 pm
Forum: ImetelChat
Topic: Quote from Dr. Stephen Hahn FDA Commissioner
Replies: 3
Views: 775

Re: Quote from Dr. Stephen Hahn FDA Commissioner

PLEASE go read Hahn's apology on Twitter for this "35%" lie. And stop spreading it, it's pure political theater. We don't even have a controlled study on these "plasma" (really should be "serum" IIRC) experiments... they've thrown pooled blood products (think about that one for a minute, they've bee...
by cheng_ho
Thu Aug 27, 2020 5:35 pm
Forum: ImetelChat
Topic: Hat tip to Jaime YMB
Replies: 3
Views: 1049

Re: Hat tip to Jaime YMB

Come on... Geron doesn't even have a lab! Imetelstat already failed so many times against solid tumors... how many more patients are you willing to sacrifice? They haven't even been able to get an approval against the much easier targets in blood cancers. They won't even have the MF trial ENROLLED u...
by cheng_ho
Mon Jul 27, 2020 8:58 pm
Forum: ImetelChat
Topic: A question for the FDA
Replies: 4
Views: 972

Re: A question for the FDA

Don't vent here, tell the FDA themselves:

https://twitter.com/US_FDA

Of course they're too busy explaining why they banned PCR tests for SARS-CoV-2 (except for the non-working CDC test) until Feb 29, and STILL don't any pharma to release info on off-label drug use for coronavirus.
by cheng_ho
Mon Jul 27, 2020 8:17 pm
Forum: ImetelChat
Topic: Gilead bringing CAR-T to more blood cancers
Replies: 2
Views: 926

Gilead bringing CAR-T to more blood cancers

https://finance.yahoo.com/news/gilead-k ... 18532.html

It's expensive, but CAR-T keeps getting approved. How long until it gets to MDS and MF?
by cheng_ho
Tue Jun 23, 2020 9:38 pm
Forum: ImetelChat
Topic: Hat tip to Bill W Cheng Ho
Replies: 3
Views: 1252

Re: Hat tip to Bill W Cheng Ho

Credit to smikhail on Seeking Alpha for this (I put that on the first four attempts to post it on the YHOO board ;)

Would like to see any evidence for any Japanese connection to Geron. Imetelstat is a commonly used research reagent in hundreds of papers.
by cheng_ho
Tue Jun 16, 2020 9:25 pm
Forum: ImetelChat
Topic: Imagine reading this
Replies: 6
Views: 1940

Re: Imagine reading this

Actually, blood can be frozen quite efficiently... remember, I spent seven years in labs freezing and reanimating human cells ;) We've been freezing and reanimating cells at >95% efficiency since 1960. It's just a matter of either finding the right antifreeze (we used glycerol or DMSO, both a little...
by cheng_ho
Tue Jun 16, 2020 9:16 pm
Forum: ImetelChat
Topic: Sergei Gryzanov now CSO of MAIA
Replies: 2
Views: 1446

Re: Sergei Gryzanov now CSO of MAIA

It is critically important to know what happens when you use a single-base telomerase inhibitor along with an oligo in vivo... in cell culture it's very effective, but AFAIK no one is bothering to try it in human trials. So much secrecy, so many "trials" just to do patent extension on old drugs, so ...
by cheng_ho
Fri Jun 12, 2020 5:37 pm
Forum: ImetelChat
Topic: By 2:30 AM Eastern time June 12th
Replies: 8
Views: 2563

Re: By 2:30 AM Eastern time June 12th

Yes but all he had to do was wait two weeks and raise at a higher stock price, that’s the part I don’t get. Price went down, not up. Scarlett knows more about the trials and competition than we do. If he raised money at $1.30, that's what he could get. Have to give him credit for knowing the market...
by cheng_ho
Thu Jun 11, 2020 9:43 pm
Forum: ImetelChat
Topic: Sergei Gryzanov now CSO of MAIA
Replies: 2
Views: 1446

Sergei Gryzanov now CSO of MAIA

Surprised to see no discussion of this on any Geron board. Geron has patents that apply to 6-thio-dG, MAIA's telomerase inhibitor. Will MAIA have to pay royalties to Geron if they succeed? Why did Sergei go to MAIA in the first place... was there just no place else for him to go after the Alios disa...
by cheng_ho
Thu Jun 11, 2020 9:39 pm
Forum: ImetelChat
Topic: By 2:30 AM Eastern time June 12th
Replies: 8
Views: 2563

Re: By 2:30 AM Eastern time June 12th

For the same reason that he sold ATM shares at $1.37... he doesn't expect the market to be interested in paying more, and there's always the threat of ARGX, CNST, or one of the dozens of other companies with trials in the MDS field lapping Geron.
by cheng_ho
Tue May 19, 2020 7:30 pm
Forum: ImetelChat
Topic: YMB Censorship and GERON’s ex-US partner? - Pt 2
Replies: 5
Views: 1944

Re: YMB Censorship and GERON’s ex-US partner? - Pt 2

You still don't understand what imetelstat is, or where it's actually made. You can buy any oligo you want from China... but you can't sell it in the US oncology market. Chinese companies willing to sell you oligos have absolutely nothing to do with Geron. You weren't kicked off YHOO by the nonexist...
by cheng_ho
Fri May 08, 2020 7:24 pm
Forum: ImetelChat
Topic: My response to Cheng Ho on SA board
Replies: 1
Views: 841

Re: My response to Cheng Ho on SA board

(?) It was you who posted about the Mayo Phase 1 study, not me. I agree that it is a grab-bag of incompatible data and that we aren't even allowed to see the follow-up data... that's been my complaint about the whole affair for years. Trying to use it, or Tefferi, to pump Geron, is totally out of da...
by cheng_ho
Thu Apr 23, 2020 6:05 pm
Forum: ImetelChat
Topic: Patience and balance are virtues needed for the Geron journey
Replies: 9
Views: 2569

Re: Patience and balance are virtues needed for the Geron journey

HI Andrew. I keep getting posts bounced with comments about "illegal or pirated software"... what does that mean? I'm no hacker. TIA


Good luck on the upcoming AA meeting. Let's hope the FDA at least doesn't make things worse.
by cheng_ho
Wed Apr 15, 2020 5:29 am
Forum: ImetelChat
Topic: If you are looking for the new shareholders letter
Replies: 7
Views: 1749

Re: If you are looking for the new shareholders letter

It's true that improperly done transfusions "can" have serious side effects. It's also true that parabiosis is a thing... even for older NFL ballplayers, let alone the typical 70-year-old MDS patient. Losing those transfusions will be a serious blow to many older MDS patients. This is a problem for ...
by cheng_ho
Sun Apr 12, 2020 6:20 pm
Forum: ImetelChat
Topic: Patience and balance are virtues needed for the Geron journey
Replies: 9
Views: 2569

Re: Patience and balance are virtues needed for the Geron journey

Thanks for your thoughts, Huntington. Please take the time to read Taleb's book "Fooled By Randomness"... it is an excellent antidote to confirmation bias and conspiracy theory, from a demonstrably successful investor. An investor speaking from a record of success rather than a record of riding Gero...
by cheng_ho
Thu Apr 09, 2020 11:28 pm
Forum: ImetelChat
Topic: Finally, a drop in short interest... why?
Replies: 0
Views: 985

Finally, a drop in short interest... why?

What caused a drop in short interest during a market downturn?
by cheng_ho
Thu Apr 09, 2020 7:10 pm
Forum: ImetelChat
Topic: If you are looking for the new shareholders letter
Replies: 7
Views: 1749

Re: If you are looking for the new shareholders letter

Good points. The blood shortage is going to get worse for several months (let's not forget that this has been coming for decades... we know very well how to cryonically store blood, but it is rarely done. Hospitals just depend on last-minute begging, which doesn't work when you can't do blood drives...