Search found 153 matches

by cheng_ho
Fri Oct 23, 2020 5:42 pm
Forum: ImetelChat
Topic: Full text link to review paper on MPNs
Replies: 0
Views: 622

Full text link to review paper on MPNs

https://sci-hub.st/10.1080/17474086.2020.1831381

Paper stresses the need for a full-length Phase 3 on imetelstat, says that presently patients' main hope is stem cell transplant. Still, at least imet is on the radar.
by cheng_ho
Fri Oct 16, 2020 4:52 pm
Forum: ImetelChat
Topic: Trying to connect dots that may or may not exist and if they do, they move like the three body problem
Replies: 5
Views: 1643

Re: Trying to connect dots that may or may not exist and if they do, they move like the three body problem

There are at least four other drugs under consideration or awarded orphan status for myelofibrosis in the EU, including luspatercept: https://www.ema.europa.eu/en/search/search/field_ema_web_categories%253Aname_field/Human/ema_group_types/ema_orphan/field_ema_orp_disease_condition%253Aname_field/Tre...
by cheng_ho
Sun Oct 04, 2020 4:20 pm
Forum: ImetelChat
Topic: Why would GERN need $75M facility?
Replies: 4
Views: 2177

Re: Why would GERN need $75M facility?

I think it's clear cut... they haven't been able to recruit enough patients for the trials, and they're behind schedule. They're just making sure that they can cross the finish line on one trial before running out of money.

And it's not $75 million UNLESS they hit their milestones.
by cheng_ho
Tue Sep 22, 2020 3:53 pm
Forum: ImetelChat
Topic: CD 47 continued again
Replies: 2
Views: 1551

Re: CD 47 continued again

There was nothing "strange" about the volume on Friday, it was index rebalancing plus a little option expiration.

You've seen this a dozen times before, just look it up.
by cheng_ho
Wed Sep 16, 2020 10:55 pm
Forum: ImetelChat
Topic: Forty Seven
Replies: 1
Views: 1285

Re: Forty Seven

Yes, this is an important result. I posted about FortySeven last year, now they have GILD backing too. While they aren't starting out aiming at low risk MDS, this could limit Geron's expansion into AML... although it's always possible that the most effective genetic targets are different, or even th...
by cheng_ho
Mon Sep 14, 2020 8:19 pm
Forum: ImetelChat
Topic: Wainright Presentation
Replies: 1
Views: 1310

Re: Wainright Presentation

I'm sure Geron will get into ASH. Even if the trial results were negative, they're still human trial results on a new MOA, so are important either way.
by cheng_ho
Mon Sep 14, 2020 8:18 pm
Forum: ImetelChat
Topic: Hoosier Investor please comment
Replies: 5
Views: 1953

Re: Hoosier Investor please comment

@Ryan: not only did I not "knock" Geron's preclinicals... I DID the first preclinicals on imetelstat while I was at Shay-Wright lab :roll: And I lost a bundle when JNJ and Scarlett tricked us into believing that JNJ was going to continue (the "job posting", the compassionate-use listing, and all the...
by cheng_ho
Mon Sep 14, 2020 8:11 pm
Forum: ImetelChat
Topic: Hoosier Investor please comment
Replies: 5
Views: 1953

Re: Hoosier Investor please comment

Thanks for looking at the patents, HI. I agree that Geron's "concept patent" (something that is not supposed to exist) on "telomerase inhibitors in MF, MDS, and AML" (I know it's three blood cancers, hope I remember the AML correctly?) does apply. The other patents mention "modified Guanines" and in...
by cheng_ho
Fri Sep 04, 2020 6:40 pm
Forum: ImetelChat
Topic: Here’s the relevant patent hat tip to Cheng Ho and Robespierre
Replies: 2
Views: 1059

Re: Here’s the relevant patent hat tip to Cheng Ho and Robespierre

The patent on "any telomerase inhibitor in MF, MDS, and AML" should apply as well.
by cheng_ho
Fri Sep 04, 2020 6:39 pm
Forum: ImetelChat
Topic: Orphan being discussed AML/MDS/JMML
Replies: 9
Views: 2537

Re: Orphan being discussed AML/MDS/JMML

What they're discussing is waiving the pediatric testing requirement, as you'll remember was done for the Phase 2.

This is a very good thing, it will speed up the trial... and as biopearl points out, incidence in children is super rare.
by cheng_ho
Tue Sep 01, 2020 9:00 pm
Forum: ImetelChat
Topic: New telomerase-inhibitor company MAIA has new paper
Replies: 0
Views: 973

New telomerase-inhibitor company MAIA has new paper

Paper on MAIA's telomerase-inhibitor drug 6-thiodG coming out this month:

https://www.businesswire.com/news/home/ ... ncouraging
by cheng_ho
Tue Sep 01, 2020 8:59 pm
Forum: ImetelChat
Topic: Current job listing
Replies: 3
Views: 1239

Re: Current job listing

No, please stop. Geron doesn't have a lab, they aren't doing any preclinicals of their own.
by cheng_ho
Thu Aug 27, 2020 5:40 pm
Forum: ImetelChat
Topic: Quote from Dr. Stephen Hahn FDA Commissioner
Replies: 3
Views: 1325

Re: Quote from Dr. Stephen Hahn FDA Commissioner

PLEASE go read Hahn's apology on Twitter for this "35%" lie. And stop spreading it, it's pure political theater. We don't even have a controlled study on these "plasma" (really should be "serum" IIRC) experiments... they've thrown pooled blood products (think about that one for a minute, they've bee...
by cheng_ho
Thu Aug 27, 2020 5:35 pm
Forum: ImetelChat
Topic: Hat tip to Jaime YMB
Replies: 3
Views: 1597

Re: Hat tip to Jaime YMB

Come on... Geron doesn't even have a lab! Imetelstat already failed so many times against solid tumors... how many more patients are you willing to sacrifice? They haven't even been able to get an approval against the much easier targets in blood cancers. They won't even have the MF trial ENROLLED u...
by cheng_ho
Mon Jul 27, 2020 8:58 pm
Forum: ImetelChat
Topic: A question for the FDA
Replies: 4
Views: 1364

Re: A question for the FDA

Don't vent here, tell the FDA themselves:

https://twitter.com/US_FDA

Of course they're too busy explaining why they banned PCR tests for SARS-CoV-2 (except for the non-working CDC test) until Feb 29, and STILL don't any pharma to release info on off-label drug use for coronavirus.
by cheng_ho
Mon Jul 27, 2020 8:17 pm
Forum: ImetelChat
Topic: Gilead bringing CAR-T to more blood cancers
Replies: 2
Views: 1235

Gilead bringing CAR-T to more blood cancers

https://finance.yahoo.com/news/gilead-k ... 18532.html

It's expensive, but CAR-T keeps getting approved. How long until it gets to MDS and MF?
by cheng_ho
Tue Jun 23, 2020 9:38 pm
Forum: ImetelChat
Topic: Hat tip to Bill W Cheng Ho
Replies: 3
Views: 1738

Re: Hat tip to Bill W Cheng Ho

Credit to smikhail on Seeking Alpha for this (I put that on the first four attempts to post it on the YHOO board ;)

Would like to see any evidence for any Japanese connection to Geron. Imetelstat is a commonly used research reagent in hundreds of papers.
by cheng_ho
Tue Jun 16, 2020 9:25 pm
Forum: ImetelChat
Topic: Imagine reading this
Replies: 6
Views: 2618

Re: Imagine reading this

Actually, blood can be frozen quite efficiently... remember, I spent seven years in labs freezing and reanimating human cells ;) We've been freezing and reanimating cells at >95% efficiency since 1960. It's just a matter of either finding the right antifreeze (we used glycerol or DMSO, both a little...
by cheng_ho
Tue Jun 16, 2020 9:16 pm
Forum: ImetelChat
Topic: Sergei Gryzanov now CSO of MAIA
Replies: 2
Views: 1833

Re: Sergei Gryzanov now CSO of MAIA

It is critically important to know what happens when you use a single-base telomerase inhibitor along with an oligo in vivo... in cell culture it's very effective, but AFAIK no one is bothering to try it in human trials. So much secrecy, so many "trials" just to do patent extension on old drugs, so ...
by cheng_ho
Fri Jun 12, 2020 5:37 pm
Forum: ImetelChat
Topic: By 2:30 AM Eastern time June 12th
Replies: 8
Views: 3383

Re: By 2:30 AM Eastern time June 12th

Yes but all he had to do was wait two weeks and raise at a higher stock price, that’s the part I don’t get. Price went down, not up. Scarlett knows more about the trials and competition than we do. If he raised money at $1.30, that's what he could get. Have to give him credit for knowing the market...