Search found 128 matches

by cheng_ho
Wed Apr 15, 2020 5:29 am
Forum: ImetelChat
Topic: If you are looking for the new shareholders letter
Replies: 7
Views: 1159

Re: If you are looking for the new shareholders letter

It's true that improperly done transfusions "can" have serious side effects. It's also true that parabiosis is a thing... even for older NFL ballplayers, let alone the typical 70-year-old MDS patient. Losing those transfusions will be a serious blow to many older MDS patients. This is a problem for ...
by cheng_ho
Sun Apr 12, 2020 6:20 pm
Forum: ImetelChat
Topic: Patience and balance are virtues needed for the Geron journey
Replies: 8
Views: 1792

Re: Patience and balance are virtues needed for the Geron journey

Thanks for your thoughts, Huntington. Please take the time to read Taleb's book "Fooled By Randomness"... it is an excellent antidote to confirmation bias and conspiracy theory, from a demonstrably successful investor. An investor speaking from a record of success rather than a record of riding Gero...
by cheng_ho
Thu Apr 09, 2020 11:28 pm
Forum: ImetelChat
Topic: Finally, a drop in short interest... why?
Replies: 0
Views: 330

Finally, a drop in short interest... why?

What caused a drop in short interest during a market downturn?
by cheng_ho
Thu Apr 09, 2020 7:10 pm
Forum: ImetelChat
Topic: If you are looking for the new shareholders letter
Replies: 7
Views: 1159

Re: If you are looking for the new shareholders letter

Good points. The blood shortage is going to get worse for several months (let's not forget that this has been coming for decades... we know very well how to cryonically store blood, but it is rarely done. Hospitals just depend on last-minute begging, which doesn't work when you can't do blood drives...
by cheng_ho
Mon Apr 06, 2020 1:05 am
Forum: ImetelChat
Topic: Reality check
Replies: 8
Views: 1294

Re: Reality check

I agree with everyone about the urgency of conserving blood (after all, we GERNiatrics need it for parabiosis ;) However, please stop saying things like: "...the FDA must do this, or they are absolutely failing their responsibility for the good of these patients, the good of the healthcare system an...
by cheng_ho
Thu Apr 02, 2020 10:02 pm
Forum: ImetelChat
Topic: SARS-CoV-2 pushes MDS enrollment and AML trial to 2021
Replies: 0
Views: 595

SARS-CoV-2 pushes MDS enrollment and AML trial to 2021

https://ir.geron.com/investors/press-releases/press-release-details/2020/Geron-Provides-COVID-19-Related-Business-Update/default.aspx Obviously, most patients will be suspending infusions until the epidemic (and the response to the epidemic, which is even more harmful) are over. This will make it ha...
by cheng_ho
Wed Apr 01, 2020 9:58 pm
Forum: ImetelChat
Topic: Telomerase
Replies: 3
Views: 963

Re: Telomerase

I answered gwik on ST... the quick answer is yes, there are many other telomerase-inhibitor drugs already in use. Azacitidine is currently in many combo trials, including the ARGX trial that JNJ funded heavily right after dropping Geron. Also check out Constellation... just do searches on "MDS" and ...
by cheng_ho
Thu Mar 26, 2020 3:59 pm
Forum: ImetelChat
Topic: Successful ABBV telomerase-inhibitor combo study in AML
Replies: 0
Views: 562

Successful ABBV telomerase-inhibitor combo study in AML

So ABBV got good results in VERY sick AML patients,using azacitidine as their telomerase inhibitor along with Venclexta. Other companies are using the ancient 1990s telomerase inhibitors in trials as well, ARGX, Constellation, and many others. Why are these companies avoiding collaboration with Gero...
by cheng_ho
Mon Mar 23, 2020 5:10 pm
Forum: ImetelChat
Topic: Since everyone is on lockdown....
Replies: 1
Views: 1780

Re: Since everyone is on lockdown....

Obviously the TERT promoter has to mutate in order to upregulate telomerase in cancer cells. What "Geron R&D" are you talking about? Did they build a lab somewhere? AFAIK they have an office in NJ that does CTPM for the trials, and an office in Menlo Park that pays the largest average salaries in CA...
by cheng_ho
Fri Mar 13, 2020 10:32 pm
Forum: ImetelChat
Topic: Good Bye
Replies: 4
Views: 1182

Re: Good Bye

Good luck, kara. Check out those papers on NAD+ boosting and telomerase activation... there's still a chance for you to hang on until the real Age Of Biotech starts.
by cheng_ho
Mon Mar 02, 2020 8:27 pm
Forum: ImetelChat
Topic: Perspective on the MF field
Replies: 7
Views: 1752

Re: Perspective on the MF field

Scarlett never addressed why JNJ was looking for a pricing manager for imetelstat for AML in addition to MDS and MF - that came out of nowhere - I would like to go to the shareholders meeting to ask him that question - was it a surprise to him or was he aware they were working on something? I am su...
by cheng_ho
Mon Mar 02, 2020 4:41 pm
Forum: ImetelChat
Topic: FTSV acquisition by GILD
Replies: 4
Views: 2065

FTSV acquisition by GILD

Clearly, big pharma is interested in the MDS/AML market, they see it as large and effective therapy as attainable.

JNJ is invested in ARGX and Constellation, now GILD has bought out FSTV.

Any thoughts as to why no pharma has shown interest in Geron?
by cheng_ho
Mon Mar 02, 2020 4:38 pm
Forum: ImetelChat
Topic: Perspective on the MF field
Replies: 7
Views: 1752

Re: Perspective on the MF field

i think they bailed due to the italian paper on MOS - when it came out there was no chance to refute it or prove it and thus they didn't feel comfortable in committing up to a billion dollars to continue - that killed the deal - the FDA must think there is something here to grant fast track after l...
by cheng_ho
Tue Feb 25, 2020 4:49 pm
Forum: ImetelChat
Topic: Perspective on the MF field
Replies: 7
Views: 1752

Perspective on the MF field

MF is a lot smaller market... but there are still many current trials, some of them even combo trials.

https://clinicaltrials.gov/ct2/results? ... ity=&dist=
by cheng_ho
Mon Feb 24, 2020 10:45 pm
Forum: ImetelChat
Topic: Review paper on low-risk MDS, brief mention of imetelstat
Replies: 0
Views: 1361

Review paper on low-risk MDS, brief mention of imetelstat

A really severe condemnation of the whole plarma/patent/FDA system... no new drug for 13 years:

https://link.springer.com/article/10.10 ... 20-03963-1
by cheng_ho
Wed Feb 19, 2020 6:39 pm
Forum: ImetelChat
Topic: new Geron patent on 6-thio-dG and other Guanine variants
Replies: 0
Views: 1270

new Geron patent on 6-thio-dG and other Guanine variants

Geron received a patent on Guanine analogs as telomerase length affectors (e.g., 6-thio-dG). More confirmation that Dr. Shay is right and that 6-thio-dG is the future... does anyone here know how this affects the MAIA IP?


https://patents.justia.com/assignee/geron-corporation
by cheng_ho
Mon Feb 10, 2020 4:01 pm
Forum: ImetelChat
Topic: Hat tip to hay flick YMB
Replies: 4
Views: 1588

Re: Hat tip to hay flick YMB

No, you were right, biopearl. Geron isn't doing genetic screening in the trials... and so far they've recruited only half the patients they need for the MDS trial, even just taking whatever victims Paraxel can find.

This is just a hope for the future. Maybe in a Phase 3 design for MF?
by cheng_ho
Sun Feb 09, 2020 2:47 pm
Forum: ImetelChat
Topic: Targeting imet on genetic subtypes: hope for effectiveness?
Replies: 0
Views: 1773

Targeting imet on genetic subtypes: hope for effectiveness?

Just as Gleevec got its reputation because it is only used on genetic subtypes where it has a better chance, Imetelstat might be developed into an effective therapy if susceptible subtypes are found. (Caffeine is actually VERY effective on cancers with a certain DNA-repair defect...) Hayflick on the...
by cheng_ho
Sun Feb 09, 2020 2:38 pm
Forum: ImetelChat
Topic: Avalanch of Classaction Lawsuits
Replies: 1
Views: 1358

Re: Avalanch of Classaction Lawsuits

Scarlett has settled past lawsuits without a fight. That's what attracts the lawyers... the last suit extracted more than $6 million, and all the firm had to do was file it. There is no Giant Short Conspiracy That Only Posts On YHOO Message Boards... no one has to pay lawyers or sharks to attack eas...