Search found 100 matches

by cheng_ho
Thu Oct 17, 2019 11:31 pm
Forum: ImetelChat
Topic: yet another paper shows that we need longer telomeres
Replies: 1
Views: 611

yet another paper shows that we need longer telomeres

Even for cancer prevention, and even in animals that don't turn off telomerase!

https://phys.org/news/2019-10-mice-born ... omeres.amp

Prevention trumps palliatives.
by cheng_ho
Thu Jul 25, 2019 9:02 pm
Forum: ImetelChat
Topic: +Seems almost impolite to speak of here
Replies: 2
Views: 1451

Re: +Seems almost impolite to speak of here

How darest thou sully the purity of the Cult with thine shameless seeking after mere food, shelter, and medical insurance! Only the highest of the high-born mayest have the honour of sacrificing their inheritance and substance into Geron. Begone before the Great Old One Rises for the next Call Of Ch...
by cheng_ho
Fri Jun 07, 2019 7:52 pm
Forum: ImetelChat
Topic: Report from Annual Meeting by Bridge from SA
Replies: 0
Views: 1130

Report from Annual Meeting by Bridge from SA

https://seekingalpha.com/instablog/2368 ... veryone-go

Bridge confirms that GERN is withholding the Mayo data. Also that they are doing no work on improving imet or imet delivery systems.
by cheng_ho
Fri Jun 07, 2019 7:50 pm
Forum: ImetelChat
Topic: Dr. Shay's update on telomerase inhibitor 6-thio-G
Replies: 6
Views: 1890

Re: Dr. Shay's update on telomerase inhibitor 6-thio-G

Yes, the priests were horrified when smallpox vaccine let some children "unnaturally" live to adulthood, and they've moaned at every advance since. (Read about Ethan Allan's fight with the clergy on vaccination...) Since I was immortalizing cells with vectors in 2001, I think you're a little out of ...
by cheng_ho
Mon Jun 03, 2019 2:53 pm
Forum: ImetelChat
Topic: Dr. Shay's update on telomerase inhibitor 6-thio-G
Replies: 6
Views: 1890

Re: Dr. Shay's update on telomerase inhibitor 6-thio-G

Kara, Geron actually has at least one patent relating to 6-thio-G... this is just another issue that makes people who follow GERN lose SAN points. The specific MOAs of imet and 6-thio-G are very different, maybe they could be used in combo? With all the GERN patents, why is Scarlett constantly tryin...
by cheng_ho
Thu May 30, 2019 2:43 pm
Forum: ImetelChat
Topic: The difference between "may suggest" and "indicates"
Replies: 6
Views: 2183

Re: The difference between "may suggest" and "indicates"

>"MF may get approved based on historical data." Yes, that has always been a major hope here (maybe the principal hope, given the competition and timeline in MDS). But it can't happen before the company at least talks to the FDA in 2020. There is plenty of time to order a short oligo from a commerci...
by cheng_ho
Thu May 30, 2019 2:35 pm
Forum: ImetelChat
Topic: An end run...
Replies: 2
Views: 1456

Re: An end run...

I agree, this is somewhat encouraging. They probably don't have useful historical controls right now because of the differences between different hospitals' protocols and generally bad databases (HIPAA didn't help the already-backwards hospital medical databases). But that doesn't that the necessary...
by cheng_ho
Thu May 30, 2019 2:32 pm
Forum: ImetelChat
Topic: how to get full text papers through sci-hub
Replies: 0
Views: 929

how to get full text papers through sci-hub

I keep seeing posts on YHOO and Seeking Alpha from people that "can't get full text of X paper", or even "I can't post the abstract to this paper".

Sci-hub solved these problems long ago, here's the link:

https://whereisscihub.now.sh/
by cheng_ho
Tue May 21, 2019 2:43 pm
Forum: ImetelChat
Topic: The difference between "may suggest" and "indicates"
Replies: 6
Views: 2183

Re: The difference between "may suggest" and "indicates"

The issue with Janssen as an imetelstat supplier is cost, not quantity. Any commercial supplier would give a better deal (kind of nasty of Janssen to charge high prices for their stockpile of a drug that they are just discarding anyway, but there it is). Again, it's the medical organization "EHA", n...
by cheng_ho
Tue May 21, 2019 2:35 pm
Forum: ImetelChat
Topic: Dr. Shay's update on telomerase inhibitor 6-thio-G
Replies: 6
Views: 1890

Re: Dr. Shay's update on telomerase inhibitor 6-thio-G

So has anyone here read this?

You can bet that JNJ read the 2015 papers.
by cheng_ho
Tue May 14, 2019 3:56 pm
Forum: ImetelChat
Topic: May 16th it is - Yet Another Day of Anticipation
Replies: 10
Views: 2695

Re: May 16th it is - Yet Another Day of Anticipation

It's the EHA, not the EMA. One tries to cure heme diseases, the other protects pharma cartel profits... try to keep them straight ;) Yes, this is the best-case scenario. IF the abstract suggests durable effectiveness, and IF we hear from Rizo instead of having the entire presentation in stuttervisio...
by cheng_ho
Thu May 02, 2019 10:43 pm
Forum: ImetelChat
Topic: Shareholder’s letter
Replies: 14
Views: 1938

Re: Shareholder’s letter

kara, neither of the Phase 2 trials have placebo arms IIRC. They are using "historical controls", which are very poor as different hospitals keep records differently and the patient groups may not be comparable. The MF trial does have some comparison available between the two dose arms, as the low-d...
by cheng_ho
Tue Apr 30, 2019 8:21 pm
Forum: ImetelChat
Topic: What makes a CEO a CEO?
Replies: 16
Views: 2692

Re: What makes a CEO a CEO?

I'm all in favor of market-based CEO compensation. I remember the hilarity that ensued when Ben&Jerry tried to hire a "CEO" for one-tenth the market rate (they ended up paying the market rate after all, big surprise). But that doesn't mean that stockholders can just go to sleep while a long-term CEO...
by cheng_ho
Mon Apr 29, 2019 11:26 pm
Forum: ImetelChat
Topic: The odds of Phase 3 success in oncology
Replies: 0
Views: 1076

The odds of Phase 3 success in oncology

This is a bit premature, but this is a 2018 paper on Phase 3 success rates broken down by category: https://academic.oup.com/biostatistics/article/20/2/273/4817524 Obviously Geron has some special factors (e.g. the large number of previous failed trials), but at least knowing the average success rat...
by cheng_ho
Mon Apr 29, 2019 4:13 pm
Forum: ImetelChat
Topic: What makes a CEO a CEO?
Replies: 16
Views: 2692

Re: What makes a CEO a CEO?

Thanks Smuggie, interesting stuff... I would have expected options to work better as incentives, at least on CEOs that are below retirement age and still have active lifespan remaining. The good news at GERN, if there is any, is that the Janssen crew knows more about the MOA than anyone else. That d...
by cheng_ho
Fri Apr 26, 2019 3:47 pm
Forum: ImetelChat
Topic: What makes a CEO a CEO?
Replies: 16
Views: 2692

Re: What makes a CEO a CEO?

Not only does the new FDA director know what a telomere is, he knows that there are multiple telomerase-inhibiting drugs that have already been used clinically since the 1990s, e.g. 6-thio-G, AZT, AZA, etc. etc.... something which GERN enthusiasts keep trying to ignore. http://www.smbc-comics.com/co...
by cheng_ho
Tue Apr 23, 2019 2:52 pm
Forum: ImetelChat
Topic: A very basic note on other telomerase inhibitors
Replies: 4
Views: 1093

Re: A very basic note on other telomerase inhibitors

JNJ may think that these older, better-tested drugs are "competitors"... but I see them as potential combos. The FDA hates anything that doesn't fit the mono or at best duo therapy model... but if you throw three selected drugs at each MOA, you can use each one at a less toxic level AND keep the can...