Search found 195 matches

by biopearl123
Sun Sep 15, 2019 2:44 am
Forum: ImetelChat
Topic: Why the late addition of an Italian site to the MF study?
Replies: 0
Views: 23

Why the late addition of an Italian site to the MF study?

Why was there a late addition of an Italian site to the MF trial (which was no longer enrolling patients)? Well one might speculate that the "outlier" study: "18.Palandri F, Elli EM, Polverelli N, Bonifacio M, Benevolo G, Abruzzese E, Bergamaschi M, Tieghi A, Iurlo A, Crugnola M, Cavazzini F, Binott...
by biopearl123
Fri Sep 06, 2019 6:25 pm
Forum: ImetelChat
Topic: A comment on a recent job posting
Replies: 0
Views: 352

A comment on a recent job posting

From Geron's "career opportunities" posting: "The Clinical Project Manager (CPM) will manage one or more allocated Phase I through IV Clinical Trials that may be local, regional or global in scope. The CPM will be 100% accountable for the success of their projects." AFAIK, there is no P I and no P I...
by biopearl123
Thu Sep 05, 2019 5:36 pm
Forum: ImetelChat
Topic: 57 P3 Site Locations and Counting?
Replies: 5
Views: 1054

Re: 57 P3 Site Locations and Counting?

I was pleased to get a prompt response from Jacob. The "completed" designation applies to part I of the study. I would hope these sites will be participating in part II but unless/until the clinical trials site is further updated we won't know. To summarize, "completed" does not mean those sites are...
by biopearl123
Wed Sep 04, 2019 5:54 pm
Forum: ImetelChat
Topic: 57 P3 Site Locations and Counting?
Replies: 5
Views: 1054

Re: 57 P3 Site Locations and Counting?

There is an understandable amount of confusion in my mind as to the actual number of sites that will be actively enrolling in Part II of the P III study. Those listed as "completed" on the surface look like they have completed enrollment in part II and are ready to treat. However, I don't know if th...
by biopearl123
Sat Aug 31, 2019 7:57 pm
Forum: ImetelChat
Topic: Similarities between Geron & PCYC by stiglg6 on YMB
Replies: 4
Views: 1212

Re: Similarities between Geron & PCYC by stiglg6 on YMB

Hunt, thanks for reposting this from YMB. I stiglg6 has followed Geron closely and made some interesting and valuable observations and while happy with the repost, he was not happy with the repost being on my moderated site. To me that is unfortunate. He has taken issue with me over my contention th...
by biopearl123
Sat Aug 31, 2019 7:48 pm
Forum: ImetelChat
Topic: 57 P3 Site Locations and Counting?
Replies: 5
Views: 1054

Re: 57 P3 Site Locations and Counting?

Back in the USA! Sorry for the radio silence, have been on a long anticipated retirement trip of a couple of weeks. Also have been trying to deal with the now several thousand bogus registration attempts. Someone (s) want to make this site unusable. Can only assume its is some form of short attack s...
by biopearl123
Sat Aug 17, 2019 4:35 am
Forum: ImetelChat
Topic: On vacation
Replies: 1
Views: 605

On vacation

Will be out of the country for a couple of weeks. Would appreciate it if any of our regulars can keep the board up to date. There is a good post from Stig on YMB and recent good discussions on SA. Best Wishes, bp
by biopearl123
Mon Aug 12, 2019 6:24 pm
Forum: ImetelChat
Topic: P III
Replies: 5
Views: 1621

Re: P III

Thanks 1boardersooner, I can't take credit for that nice summation, it belongs to Ryan, a long time contributor. bp
by biopearl123
Thu Aug 08, 2019 3:14 pm
Forum: ImetelChat
Topic: P III
Replies: 5
Views: 1621

P III

by biopearl123
Wed Aug 07, 2019 12:22 am
Forum: ImetelChat
Topic: Imetelstat: The First Disease-Modifying Drug for Myelodysplastic Syndromes?
Replies: 4
Views: 1036

Re: Imetelstat: The First Disease-Modifying Drug for Myelodysplastic Syndromes?

kara, I think the low valuation is a strong reflection of the disillusionment and disappointment that accompanied the Janssen rejection. Not to mention the litany of failed studies and unfulfilled promises. That ought to do it. To some however that strange sequence of events and marked depression of...
by biopearl123
Tue Aug 06, 2019 8:23 pm
Forum: ImetelChat
Topic: Imetelstat: The First Disease-Modifying Drug for Myelodysplastic Syndromes?
Replies: 4
Views: 1036

Re: Imetelstat: The First Disease-Modifying Drug for Myelodysplastic Syndromes?

Ryan, thanks for your comments and for the link. It is a very nice summation from EHA. Yes, first in class, new drug should get a little more respect. Your point about waiting three years is an important one and it appears the market is thinking just that. I think those who follow the company such a...
by biopearl123
Tue Aug 06, 2019 2:16 am
Forum: ImetelChat
Topic: Excellent blog on SA
Replies: 0
Views: 775

Excellent blog on SA

One of our excellent posters has made some terrific contributions on SA and has some articles and blogs which are very worthwhile. Here is the latest:

Geron: The Dilution Solution. - Bridge to sell | Seeking Alpha
by biopearl123
Thu Jul 25, 2019 10:57 pm
Forum: ImetelChat
Topic: General Info
Replies: 10
Views: 1806

General Info

Fellow Board Members: Every day I check this board a few times in fulfillment of my responsibilities as moderator. There are usually a few requests for approval to post which I have granted with the exception of anything that looks like a robot or a potential spam generator. Today this board was bom...
by biopearl123
Tue Jul 16, 2019 8:50 pm
Forum: ImetelChat
Topic: Sdraw
Replies: 3
Views: 4033

Re: Sdraw

rinconj, I agree, it would be very reassuring to hear from him right about now. bp
by biopearl123
Tue Jul 16, 2019 6:30 am
Forum: ImetelChat
Topic: +Seems almost impolite to speak of here
Replies: 2
Views: 972

Re: +Seems almost impolite to speak of here

Gwikley, I can offer no counter argument. This has been a terrible investment, but is probably one of the longest surviving independent biotechs and may yet cross the finish line. bp
by biopearl123
Mon Jul 15, 2019 6:18 pm
Forum: ImetelChat
Topic: Just for fun while we wait, a repost from SA
Replies: 4
Views: 1578

Re: Just for fun while we wait, a repost from SA

esf, great thought but there could be no combo therapy trials in patients without FDA approval but there is some likelihood that research continues in the lab with various combination therapies. bp
by biopearl123
Tue Jul 09, 2019 11:53 pm
Forum: ImetelChat
Topic: Clinical Trials MDS site update
Replies: 1
Views: 1425

Re: Clinical Trials MDS site update

MF study also upgraded today to reflect transfer to Geron sponsorship. Also "new" site added which is a little confusing since the study stopped enrolling some time ago. I suspect this addition represents a site contributing Real World Data on a patient(s) only to enhance the "control" arm data. bp
by biopearl123
Mon Jul 08, 2019 5:30 pm
Forum: ImetelChat
Topic: Clinical Trials MDS site update
Replies: 1
Views: 1425

Clinical Trials MDS site update

The clinical trials site has been updated to reflect apparent finalization of study sites and anticipated end of study dates. No surprises yet. If the primary end point is truly 8 weeks of TI (more likely the FDA would be moved by 24 week TI rates), then it seems possible that the data may be presen...