Search found 223 matches

by biopearl123
Mon Nov 11, 2019 4:38 pm
Forum: ImetelChat
Topic: The most important focus of the new MF abstract
Replies: 2
Views: 407

Re: The most important focus of the new MF abstract

STA, I don't think a new PIII could possibly start out of the gate until further lab studies, dosing studies, human safety studies etc were done. While synergism has its obvious benefits, the potential for synergistic toxicities also need to be evaluated. I think there is much work required before a...
by biopearl123
Mon Nov 11, 2019 6:00 am
Forum: ImetelChat
Topic: The most important focus of the new MF abstract
Replies: 2
Views: 407

The most important focus of the new MF abstract

To Ryan's point about AML, when the venetoclax/imet AML study was presented, I essentially went all in (not my smartest investment move), when it was stated that "cures" were effected in a number of mice. We all know that this did not translate into a clinical study, at least as yet, for opaque reas...
by biopearl123
Sat Nov 09, 2019 6:35 pm
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 965

Re: Ash posters

Hi Ryan, thank you for your thoughts as usual. Yes it is clear the focus is on single agent use in the clinic now. Perhaps Geron felt it had enough to go to the FDA in Q1 with out providing additional RWD in the public domaine and didn't want to expend energy in this direction. Same for updating the...
by biopearl123
Fri Nov 08, 2019 5:50 pm
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 965

Re: Ash posters

J Lennon actually said, "you may say I'm a dreamer, but I'm not the only one." He would have plenty of company on this board. There was no reason I can think of not to update the durability data for TI to further shore up further respect for drug effect, unless there is not. Usually silence is not n...
by biopearl123
Thu Nov 07, 2019 2:18 am
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 965

Re: Ash posters

Ryan, thanks for your post. I see this a little differently. 1. There is no mention of AML probably because the program is probably dead in the water and Scarlett always skirts this issue (its oh so complicated, etc). 2. There are only two(or three counting the one Geron did not mention in the compa...
by biopearl123
Thu Oct 31, 2019 10:30 pm
Forum: ImetelChat
Topic: looks like the latest three posted jobs have been filled
Replies: 4
Views: 874

Re: looks like the latest three posted jobs have been filled

STA, since those positions remain posted as of today, I think the ever parsimonious Scarlett will deal with this during whatever PR accompanies the Nov 6th "earnings" report and discussion of submissions to ASH. bp
by biopearl123
Thu Oct 31, 2019 10:27 pm
Forum: ImetelChat
Topic: Q3 announcement coincides w ASH abstract release
Replies: 5
Views: 675

Re: Q3 announcement coincides w ASH abstract release

musketeer, yes. That way they have something to talk about ("within the four corners of the abstract(s)). This will help to offset the terrible continuing hemorrhage (and dilution) of $$ as they run to the finish line (FDA meeting Q1). bp
by biopearl123
Thu Oct 31, 2019 2:13 am
Forum: ImetelChat
Topic: Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers
Replies: 1
Views: 203

Re: Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers

nerdy boy, thank you for posting this. There is no doubt that the telomere is an essential part of normal cellular physiology as well as cancer pathology. That Geron holds IP in this area and has the only telomerase inhibitor in the clinic should be of great value. And yet... Regards, bp
by biopearl123
Wed Oct 30, 2019 11:33 pm
Forum: ImetelChat
Topic: looks like the latest three posted jobs have been filled
Replies: 4
Views: 874

Re: looks like the latest three posted jobs have been filled

STA, I will be happy to try. Let you know what happens if anything. bp
by biopearl123
Mon Oct 28, 2019 11:10 pm
Forum: ImetelChat
Topic: looks like the latest three posted jobs have been filled
Replies: 4
Views: 874

Re: looks like the latest three posted jobs have been filled

But oddly the web site has not been updated as of today 10/28. Perhaps the three positions that received inducement grants are not the same three jobs posted on the company site. Or perhaps the IR is just lazy. bp
by biopearl123
Mon Oct 21, 2019 8:36 pm
Forum: ImetelChat
Topic: Dr. Rizo Abstracts
Replies: 1
Views: 674

Re: Dr. Rizo Abstracts

Hi Ryan, Agree it it highly likely we will see new abstracts submitted (and accepted) to ASH. We are in the home stretch before FDA Q1 meeting so ASH should give us a window as to what data will be part of the final presentation. That granting of fast track in MF followed the cut off date for abstra...
by biopearl123
Fri Oct 18, 2019 2:13 am
Forum: ImetelChat
Topic: yet another paper shows that we need longer telomeres
Replies: 1
Views: 584

Re: yet another paper shows that we need longer telomeres

Thank you Bill, Dr. Blasco has quite the impressive CV: https://orcid.org/0000-0002-4211-233X
by biopearl123
Fri Oct 18, 2019 1:59 am
Forum: ImetelChat
Topic: looks like the latest three posted jobs have been filled
Replies: 4
Views: 874

looks like the latest three posted jobs have been filled

PR today indicates inducement grants of 200,000 shares allowed toward three positions. Geron web site does not yet reflect, but it appears the three remaining posted jobs have been filled. Scarlett should be at fighting weight going into ASH and meeting with FDA Q1. Next quarterly update will likely...
by biopearl123
Wed Oct 16, 2019 7:28 pm
Forum: ImetelChat
Topic: First patient dosed in part II MDS study
Replies: 2
Views: 824

Re: First patient dosed in part II MDS study

Zhears, I have to agree, its it taking a long time. I estimate we lost an entire year given Janssen's decision. They could have just started part II, tacked on to part I almost exactly one year ago. To your point specifically however, you would think patients would be lined up to enroll, even if 1/3...
by biopearl123
Thu Oct 10, 2019 11:33 pm
Forum: ImetelChat
Topic: What to expect in the next month
Replies: 0
Views: 592

What to expect in the next month

I think we might see some activity on the following fronts: 1. Announcement of first patient dosed (imminent) along with an update of addition of new sites (North Dakota, Israel etc as outlined in new side presentation) along with changes in status to active in sites now designated as completed or i...
by biopearl123
Thu Oct 03, 2019 5:12 pm
Forum: ImetelChat
Topic: New Corporate presentation
Replies: 4
Views: 1181

Re: New Corporate presentation

Yes, I have definitely seen them do this in the past. bp
by biopearl123
Wed Oct 02, 2019 6:11 pm
Forum: ImetelChat
Topic: More insight into the Italian study (speculative)
Replies: 0
Views: 615

More insight into the Italian study (speculative)

As everyone knows the MF clinical trials site was updated on in July to reflect the addition of a single Italian site (that interestingly was the source of a study suggesting MOS of 22 months). Also during this time period Geron would have had to initiated application for fast track (FT is initiated...