Search found 254 matches

by biopearl123
Thu Feb 13, 2020 4:47 pm
Forum: ImetelChat
Topic: A Salute to Memom
Replies: 5
Views: 792

Re: A Salute to Memom

Commsman, the evil and sadness of cancer has affected us all. Thank you for sharing this touching family story. bp
by biopearl123
Mon Feb 10, 2020 2:15 am
Forum: ImetelChat
Topic: Hat tip to hay flick YMB
Replies: 3
Views: 617

Re: Hat tip to hay flick YMB

Ryan, I think you were the one who said Geron was screening on the basis of molecular signature and I took issue since there was no mention on the clinical trials site. Looks like you will tun out to be right for future use!! I hope so. Regards, bp
by biopearl123
Sun Feb 09, 2020 7:47 pm
Forum: ImetelChat
Topic: Hat tip to hay flick YMB
Replies: 3
Views: 617

Re: Hat tip to hay flick YMB

Worth a read in light of the WIPO post:

https://www.nature.com/articles/leu2013 ... rigin=ppub
by biopearl123
Fri Jan 24, 2020 12:11 am
Forum: ImetelChat
Topic: Geron Home Page
Replies: 0
Views: 1055

Geron Home Page

For those of you who obsessively check Geron's home page (I do, but mostly out a a sense of obligation to this board) its pretty clear that the careers section hasn't been updated despite the high probability that the positions have been filled several weeks ago and the options that attach issued. S...
by biopearl123
Mon Jan 13, 2020 9:48 pm
Forum: ImetelChat
Topic: New Company presentation
Replies: 1
Views: 901

New Company presentation

https://s24.q4cdn.com/668523011/files/doc_presentations/2020/Geron-Corporate-Presentation-JPM-Jan-2020-01.13.2020-FINAL.pdf A few observation about the new presentation. 1. Emphasis on new class and IP protection to 2033 (they will need it at this rate). 2. New PIII MDS proposals to FDA--this does n...
by biopearl123
Mon Dec 30, 2019 7:19 pm
Forum: ImetelChat
Topic: Parsing the obnubulate Scarlett
Replies: 6
Views: 1965

Re: Parsing the obnubulate Scarlett

STA, I agree completely with your thoughts. A combo study would probably be the slowest path, possibly requiring a PII first. I have been intrigued by this statement in the last PR: " (i) whether regulatory authorities permit the further development of imetelstat for relapsed/refractory MF before Ge...
by biopearl123
Fri Dec 27, 2019 4:14 pm
Forum: ImetelChat
Topic: 14 months since Gernobyl
Replies: 2
Views: 980

Re: 14 months since Gernobyl

Signet 01, you are quite correct, but the CD was to be based largely on the MF data if I remember correctly. Later Scarlett said Janssen would also take the MDS data into consideration before making a final decision. Regards, bp
by biopearl123
Fri Dec 27, 2019 3:59 am
Forum: ImetelChat
Topic: 14 months since Gernobyl
Replies: 2
Views: 980

14 months since Gernobyl

Well its been about 14 months since Gernobyl. Since that time (ignoring the stock price) some very good things have happened. We have a first class management and development team, fast track in two indications, money in the bank, optimistic meetings with the FDA and multiple signals that manufactur...
by biopearl123
Mon Dec 23, 2019 3:12 am
Forum: ImetelChat
Topic: Parsing the obnubulate Scarlett
Replies: 6
Views: 1965

Re: Parsing the obnubulate Scarlett

I would submit that that need is not met. Rux is a treatment for symptoms but has not been clearly associated with disease modification. With front line there is potential to change the course of a uniformly fatal disease. I think the potential to help many more patients live longer and better is be...
by biopearl123
Sun Dec 22, 2019 9:06 pm
Forum: ImetelChat
Topic: Parsing the obnubulate Scarlett
Replies: 6
Views: 1965

Parsing the obnubulate Scarlett

What to make of the last press release re the EOP2 meeting with the Feds? Here we have this:"Based on feedback from the meeting, over the coming months Geron plans to submit several Phase 3 trial design proposals in relapsed/refractory MF and to have further discussions with the FDA regarding potent...
by biopearl123
Fri Dec 20, 2019 5:16 pm
Forum: ImetelChat
Topic: AGIO <--> GERN ....CoRelation?
Replies: 1
Views: 1014

Re: AGIO <--> GERN ....CoRelation?

I don't think its a matter of number of patients but in Agios case a defined molecular target IDH1, something present in <4% of MDS patients. The FDA seems to like targeted molecular end points. bp
by biopearl123
Thu Dec 19, 2019 12:04 am
Forum: ImetelChat
Topic: FDA meeting Press Release
Replies: 4
Views: 1333

Re: FDA meeting Press Release

rccola, I don't see why the FDA should feel compelled to grant AA without some period of time to evaluate whatever was presented at the meeting. I am not sure that the jury isn't still out. bp
by biopearl123
Wed Dec 18, 2019 7:44 pm
Forum: ImetelChat
Topic: Registration
Replies: 0
Views: 797

Registration

I just deleted another 6000 (!!) bogus registration attempts. I can only hope that there were some legit requests buried in these requests but I truly have no way to know. So if you are sincerely interested in posting here please send me a PM on SA and I will watch for your request and allow activat...
by biopearl123
Wed Dec 18, 2019 12:23 am
Forum: ImetelChat
Topic: Thoughts on the appendix
Replies: 1
Views: 833

Thoughts on the appendix

No not that appendix, this one: https://www.nejm.org/doi/suppl/10.1056/NEJMoa1310523/suppl_file/nejmoa1310523_appendix.pdf As part of the 2015 Tefferi article in the NEJM the 4 CR or PR patients were presented in the appendix. It is worth a read. And yes Bill, for unknown reasons Tefferi "damned wit...
by biopearl123
Thu Dec 12, 2019 4:17 am
Forum: ImetelChat
Topic: Musings on what Scarlett will bring to the FDA
Replies: 2
Views: 1610

Re: Musings on what Scarlett will bring to the FDA

Nope, no surprises, no updates, some early work re combo therapy. Waiting for FDA meeting.
by biopearl123
Wed Dec 04, 2019 7:12 pm
Forum: ImetelChat
Topic: Musings on what Scarlett will bring to the FDA
Replies: 2
Views: 1610

Musings on what Scarlett will bring to the FDA

I thought it might be fun to compile a list of what might go before the FDA at the end of PII meeting presumptively scheduled for March 2020. I invite board members to add or subtract and to help rank order in terms of importance: 1. The MF study that demonstrates significant MOS improvement. That d...