Search found 210 matches

by biopearl123
Fri Oct 18, 2019 2:13 am
Forum: ImetelChat
Topic: yet another paper shows that we need longer telomeres
Replies: 1
Views: 149

Re: yet another paper shows that we need longer telomeres

Thank you Bill, Dr. Blasco has quite the impressive CV: https://orcid.org/0000-0002-4211-233X
by biopearl123
Fri Oct 18, 2019 1:59 am
Forum: ImetelChat
Topic: looks like the latest three posted jobs have been filled
Replies: 0
Views: 104

looks like the latest three posted jobs have been filled

PR today indicates inducement grants of 200,000 shares allowed toward three positions. Geron web site does not yet reflect, but it appears the three remaining posted jobs have been filled. Scarlett should be at fighting weight going into ASH and meeting with FDA Q1. Next quarterly update will likely...
by biopearl123
Wed Oct 16, 2019 7:28 pm
Forum: ImetelChat
Topic: First patient dosed in part II MDS study
Replies: 2
Views: 531

Re: First patient dosed in part II MDS study

Zhears, I have to agree, its it taking a long time. I estimate we lost an entire year given Janssen's decision. They could have just started part II, tacked on to part I almost exactly one year ago. To your point specifically however, you would think patients would be lined up to enroll, even if 1/3...
by biopearl123
Thu Oct 10, 2019 11:33 pm
Forum: ImetelChat
Topic: What to expect in the next month
Replies: 0
Views: 355

What to expect in the next month

I think we might see some activity on the following fronts: 1. Announcement of first patient dosed (imminent) along with an update of addition of new sites (North Dakota, Israel etc as outlined in new side presentation) along with changes in status to active in sites now designated as completed or i...
by biopearl123
Thu Oct 03, 2019 5:12 pm
Forum: ImetelChat
Topic: New Corporate presentation
Replies: 4
Views: 901

Re: New Corporate presentation

Yes, I have definitely seen them do this in the past. bp
by biopearl123
Wed Oct 02, 2019 6:11 pm
Forum: ImetelChat
Topic: More insight into the Italian study (speculative)
Replies: 0
Views: 397

More insight into the Italian study (speculative)

As everyone knows the MF clinical trials site was updated on in July to reflect the addition of a single Italian site (that interestingly was the source of a study suggesting MOS of 22 months). Also during this time period Geron would have had to initiated application for fast track (FT is initiated...
by biopearl123
Mon Sep 30, 2019 11:37 pm
Forum: ImetelChat
Topic: 57 P3 Site Locations and Counting?
Replies: 8
Views: 2157

Re: 57 P3 Site Locations and Counting?

rccola335, I think your math is correct and the total number of patients is as you say 225 but since the first 55 are not randomized, it is reasonable to suggest that part I will lack the statistical validity required by the FDA (no p value or Kaplan Meier curves). Part II should address this, but w...
by biopearl123
Mon Sep 30, 2019 11:30 pm
Forum: ImetelChat
Topic: Full Separation from Janssen???
Replies: 2
Views: 543

Re: Full Separation from Janssen???

It seems likely we will know after Friday's presentation if not before. bp
by biopearl123
Mon Sep 30, 2019 11:28 pm
Forum: ImetelChat
Topic: Fast Track for MF!
Replies: 1
Views: 381

Re: Fast Track for MF!

Thanks Ryan, you got to this before I did. It is welcome news. I think have a rolling submission process in place could mean that time to approval following the FDA meeting 1st quarter could be short. bp
by biopearl123
Mon Sep 30, 2019 11:25 pm
Forum: ImetelChat
Topic: Fast Track for MF!
Replies: 2
Views: 355

Re: Fast Track for MF!

by biopearl123
Sat Sep 28, 2019 10:14 pm
Forum: ImetelChat
Topic: A wild hope to keep this board relevent
Replies: 6
Views: 671

Re: A wild hope to keep this board relevent

Thank you Jingle, Buc and G., Jingledsassy, it is my sincerest hope that I am not the lead lemming. Thank you all for your support. bp
by biopearl123
Sat Sep 28, 2019 10:10 pm
Forum: ImetelChat
Topic: A salute to Kmall
Replies: 1
Views: 307

A salute to Kmall

Kmall, well you have made a virtual trip around the world to our benefit and to the benefit of patients who may benefit from all of your efforts. Now on to the real world (I don't know if you realize that you are making a metaphorical evolution to RWD!). I salute your efforts to bring the Imetelstat...
by biopearl123
Fri Sep 27, 2019 3:28 am
Forum: ImetelChat
Topic: A wild hope to keep this board relevent
Replies: 6
Views: 671

A wild hope to keep this board relevent

Fellow board members, In a wild and perhaps unattainable hope, I have culled what appear to be the over 6500 bogus "requests" for posting privileges. To those (and it could only be one person for all I know) who are trying to destroy this board, I ask you in the kindest way to leave us alone and all...
by biopearl123
Sun Sep 15, 2019 2:44 am
Forum: ImetelChat
Topic: Why the late addition of an Italian site to the MF study?
Replies: 0
Views: 1119

Why the late addition of an Italian site to the MF study?

Why was there a late addition of an Italian site to the MF trial (which was no longer enrolling patients)? Well one might speculate that the "outlier" study: "18.Palandri F, Elli EM, Polverelli N, Bonifacio M, Benevolo G, Abruzzese E, Bergamaschi M, Tieghi A, Iurlo A, Crugnola M, Cavazzini F, Binott...
by biopearl123
Fri Sep 06, 2019 6:25 pm
Forum: ImetelChat
Topic: A comment on a recent job posting
Replies: 0
Views: 1015

A comment on a recent job posting

From Geron's "career opportunities" posting: "The Clinical Project Manager (CPM) will manage one or more allocated Phase I through IV Clinical Trials that may be local, regional or global in scope. The CPM will be 100% accountable for the success of their projects." AFAIK, there is no P I and no P I...
by biopearl123
Thu Sep 05, 2019 5:36 pm
Forum: ImetelChat
Topic: 57 P3 Site Locations and Counting?
Replies: 8
Views: 2157

Re: 57 P3 Site Locations and Counting?

I was pleased to get a prompt response from Jacob. The "completed" designation applies to part I of the study. I would hope these sites will be participating in part II but unless/until the clinical trials site is further updated we won't know. To summarize, "completed" does not mean those sites are...
by biopearl123
Wed Sep 04, 2019 5:54 pm
Forum: ImetelChat
Topic: 57 P3 Site Locations and Counting?
Replies: 8
Views: 2157

Re: 57 P3 Site Locations and Counting?

There is an understandable amount of confusion in my mind as to the actual number of sites that will be actively enrolling in Part II of the P III study. Those listed as "completed" on the surface look like they have completed enrollment in part II and are ready to treat. However, I don't know if th...
by biopearl123
Sat Aug 31, 2019 7:57 pm
Forum: ImetelChat
Topic: Similarities between Geron & PCYC by stiglg6 on YMB
Replies: 4
Views: 1772

Re: Similarities between Geron & PCYC by stiglg6 on YMB

Hunt, thanks for reposting this from YMB. I stiglg6 has followed Geron closely and made some interesting and valuable observations and while happy with the repost, he was not happy with the repost being on my moderated site. To me that is unfortunate. He has taken issue with me over my contention th...