Search found 235 matches
- Wed Dec 04, 2019 7:12 pm
- Forum: ImetelChat
- Topic: Musings on what Scarlett will bring to the FDA
- Replies: 0
- Views: 213
Musings on what Scarlett will bring to the FDA
I thought it might be fun to compile a list of what might go before the FDA at the end of PII meeting presumptively scheduled for March 2020. I invite board members to add or subtract and to help rank order in terms of importance: 1. The MF study that demonstrates significant MOS improvement. That d...
- Tue Dec 03, 2019 2:53 pm
- Forum: ImetelChat
- Topic: New Geron Hire
- Replies: 0
- Views: 242
- Sat Nov 30, 2019 11:06 pm
- Forum: ImetelChat
- Topic: New article re ET
- Replies: 8
- Views: 1860
Re: New article re ET
Hunting, you are right about that. The great unknown and Scarlett’s hidden card up his sleeve is whether “disease modification” extends to altering progression to AML. I have submitted this question to annual meetings for the past few years but it has never been adequately addressed. In theory, this...
- Sat Nov 30, 2019 8:52 pm
- Forum: ImetelChat
- Topic: New article re ET
- Replies: 8
- Views: 1860
Re: New article re ET
Well, here is how Blood Advances defines “Stimulus Report” : ”To complement the clinical case reports, we also recognize that there can be more basic scientific insights that also can provide novel information or mechanisms in a short format that we have termed Stimulus Reports. “
- Sat Nov 30, 2019 8:32 pm
- Forum: ImetelChat
- Topic: New article re ET
- Replies: 8
- Views: 1860
Re: New article re ET
Hi Hunting, the issue for ET is that primary treatment is essentially aspirin so there is no market despite impressive anticlonal data. This study emphasizes the selective nature of Imet (a very good attribute) across myleoproliferative diseases, in this case, ET, complementing the previously presen...
- Wed Nov 27, 2019 10:34 pm
- Forum: ImetelChat
- Topic: New article re ET
- Replies: 8
- Views: 1860
Re: New article re ET
So why are we seeing old ET data repackaged and published now? The article I posted is a rehash of 2011 ASH abstract, I don't see anything really new, does anyone else? Dr. Boerlacher has basically been MIA and I have not seen her as an integral part of the MF or MDS studies. This is a glaring absen...
- Wed Nov 27, 2019 10:34 pm
- Forum: ImetelChat
- Topic: New article re ET
- Replies: 8
- Views: 1860
Re: New article re ET
So why are we seeing old ET data repackaged and published now? The article I posted is a rehash of 2011 ASH abstract, I don't see anything really new, does anyone else? Dr. Boerlacher has basically been MIA and I have not seen her as an integral part of the MF or MDS studies. This is a glaring absen...
- Wed Nov 27, 2019 3:50 pm
- Forum: ImetelChat
- Topic: New article re ET
- Replies: 8
- Views: 1860
Re: New article re ET
Seems to be a rehash of old data from 2011 ASH abstract bp
- Wed Nov 27, 2019 2:51 pm
- Forum: ImetelChat
- Topic: New article re ET
- Replies: 8
- Views: 1860
- Mon Nov 25, 2019 7:14 pm
- Forum: ImetelChat
- Topic: ASH 2019
- Replies: 3
- Views: 864
Re: ASH 2019
Hi Ryan, the abstract makes mention of the Part I results. If this were an oral presentation the think an update of the Part I data would be appropriate and probably part of the presentation. The poster however will probably just reflect the abstract as presented (but I would love to see more data t...
- Mon Nov 18, 2019 10:24 pm
- Forum: ImetelChat
- Topic: Dr. Uwe Platzbecker
- Replies: 1
- Views: 563
Re: Dr. Uwe Platzbecker
Ryan, thanks for posting. Good point. Interesting that the primary presenter is European and the big news clinical news seems to find its way to EHA over ASH. bp
- Mon Nov 18, 2019 7:57 pm
- Forum: ImetelChat
- Topic: The "other two" abstracts
- Replies: 0
- Views: 520
The "other two" abstracts
First off, thanks to recent posters, hunt and commsman, for their contributions and thoughts. I wanted to mention the "other two" ASH abstracts related to Geron but not acknowledged in the recent PR. You can read them here (in addition to the two that Geron has referenced): https://ash.confex.com/as...
- Mon Nov 11, 2019 4:38 pm
- Forum: ImetelChat
- Topic: The most important focus of the new MF abstract
- Replies: 2
- Views: 607
Re: The most important focus of the new MF abstract
STA, I don't think a new PIII could possibly start out of the gate until further lab studies, dosing studies, human safety studies etc were done. While synergism has its obvious benefits, the potential for synergistic toxicities also need to be evaluated. I think there is much work required before a...
- Mon Nov 11, 2019 6:00 am
- Forum: ImetelChat
- Topic: The most important focus of the new MF abstract
- Replies: 2
- Views: 607
The most important focus of the new MF abstract
To Ryan's point about AML, when the venetoclax/imet AML study was presented, I essentially went all in (not my smartest investment move), when it was stated that "cures" were effected in a number of mice. We all know that this did not translate into a clinical study, at least as yet, for opaque reas...
- Sat Nov 09, 2019 6:35 pm
- Forum: ImetelChat
- Topic: Ash posters
- Replies: 9
- Views: 1202
Re: Ash posters
Hi Ryan, thank you for your thoughts as usual. Yes it is clear the focus is on single agent use in the clinic now. Perhaps Geron felt it had enough to go to the FDA in Q1 with out providing additional RWD in the public domaine and didn't want to expend energy in this direction. Same for updating the...
- Fri Nov 08, 2019 5:50 pm
- Forum: ImetelChat
- Topic: Ash posters
- Replies: 9
- Views: 1202
Re: Ash posters
J Lennon actually said, "you may say I'm a dreamer, but I'm not the only one." He would have plenty of company on this board. There was no reason I can think of not to update the durability data for TI to further shore up further respect for drug effect, unless there is not. Usually silence is not n...
- Thu Nov 07, 2019 2:18 am
- Forum: ImetelChat
- Topic: Ash posters
- Replies: 9
- Views: 1202
Re: Ash posters
Ryan, thanks for your post. I see this a little differently. 1. There is no mention of AML probably because the program is probably dead in the water and Scarlett always skirts this issue (its oh so complicated, etc). 2. There are only two(or three counting the one Geron did not mention in the compa...
- Wed Nov 06, 2019 4:12 pm
- Forum: ImetelChat
- Topic: Ash posters
- Replies: 9
- Views: 1202
- Thu Oct 31, 2019 10:30 pm
- Forum: ImetelChat
- Topic: looks like the latest three posted jobs have been filled
- Replies: 4
- Views: 1060
Re: looks like the latest three posted jobs have been filled
STA, since those positions remain posted as of today, I think the ever parsimonious Scarlett will deal with this during whatever PR accompanies the Nov 6th "earnings" report and discussion of submissions to ASH. bp
- Thu Oct 31, 2019 10:27 pm
- Forum: ImetelChat
- Topic: Q3 announcement coincides w ASH abstract release
- Replies: 5
- Views: 845
Re: Q3 announcement coincides w ASH abstract release
musketeer, yes. That way they have something to talk about ("within the four corners of the abstract(s)). This will help to offset the terrible continuing hemorrhage (and dilution) of $$ as they run to the finish line (FDA meeting Q1). bp