Search found 72 matches

by Ryan
Thu Jul 02, 2020 9:14 am
Forum: ImetelChat
Topic: EU orphan status
Replies: 9
Views: 1291

Re: EU orphan status

I was just about to note that Imet received Orphan Status, for MF, about 5 years ago when BP kindly, and diligently, actually pulled the exact date and provided the facts. This is a great thread, I can’t disagree with a word here. The only thing I can say is - anticipating a breakthrough has been a ...
by Ryan
Sun Jun 07, 2020 7:23 pm
Forum: ImetelChat
Topic: Thoughts from the shareholder meeting
Replies: 6
Views: 1644

Re: Thoughts from the shareholder meeting

Thanks for the concise summation, I did not have a chance to tune in live. I especially appreciate the paragraph breaks, a lot easier on the eyes. I think they've confirmed the uniqueness of Imetelstat numerous times, however very few were buying it (all puns intended) - now looks like some heavy hi...
by Ryan
Sat May 30, 2020 2:34 am
Forum: ImetelChat
Topic: Re new presentation
Replies: 2
Views: 892

Re: Re new presentation

This was explicitly stated in the conference call:

Analyst - “It’s the go big or go home approach”
Dr. Rizo - “Exactly.”

So to your statement, “exactly” ;)
by Ryan
Sat May 23, 2020 7:16 pm
Forum: ImetelChat
Topic: Thoughts on this interesting take from YMB:
Replies: 10
Views: 1599

Re: Thoughts on this interesting take from YMB:

You’re probably right - I just get rubbed wrong by the implication that a partner is coming in because they know that their partnership will drive up the price and allow them to sell. I guess I am feel any partnership would be more altruistic than that. With all that said, these shares could have be...
by Ryan
Sat May 23, 2020 2:45 pm
Forum: ImetelChat
Topic: Thoughts on this interesting take from YMB:
Replies: 10
Views: 1599

Re: Thoughts on this interesting take from YMB:

Because the shares may be going to a partner, but a Biopharma wouldn’t be taking a stake in order to arbitrage the shares (as is the implication) - they would be taking a stake in order to fund and have a stake in Imetelstat. Stick with that, not some conspiracy theory (unfounded w no facts or even ...
by Ryan
Sat May 23, 2020 2:36 am
Forum: ImetelChat
Topic: Thoughts on this interesting take from YMB:
Replies: 10
Views: 1599

Re: Thoughts on this interesting take from YMB:

It’s conjecture and half-baked at that.
by Ryan
Fri May 22, 2020 6:31 pm
Forum: ImetelChat
Topic: Hard to take with a smile.
Replies: 1
Views: 766

Re: Hard to take with a smile.

While I understand, I’ll caution you that you’re focusing on the wrong Press Release(s). The two I focus on are the MF Phase III one and the EHA abstracts one. Yes the total shares are essentially doubling, however the value of the company has increased many, many fold with 2 Phase IIIs and the abil...
by Ryan
Thu May 21, 2020 3:22 am
Forum: ImetelChat
Topic: A few thoughts
Replies: 3
Views: 840

Re: A few thoughts

Agreed on essentially all points.

As the song goes, Dr. Scarlett and team has “given us something to talk about”.

My wild guess is the European partner for Imetelstat will be announced shortly before the conference.
by Ryan
Fri May 15, 2020 9:09 pm
Forum: ImetelChat
Topic: EHA Abstracts
Replies: 2
Views: 1433

Re: EHA Abstracts

I think this copy/paste of what I wrote on Yahoo! pretty much sums it up: Piles and piles and piles of flimsy data... All that flimsy data stacked on itself over the course of over a decade, adds up to - A drug therapy (in mono) that has proven* to have a strong safety profile and oh by the way deli...
by Ryan
Sun Apr 26, 2020 9:52 pm
Forum: ImetelChat
Topic: Near term events
Replies: 3
Views: 1233

Re: Near term events

What’s left of the optimism and patience I have left, is being exuded for these next 4-6 weeks. A decade of groundbreaking preclinical work + early and mid-stage trials, which have shown an acceptable safety profile along with efficacious effects for patients, makes the path of Imetelstat primed for...
by Ryan
Wed Mar 18, 2020 9:37 pm
Forum: ImetelChat
Topic: AML - Q4
Replies: 6
Views: 2345

Re: AML - Q4

AML is such a massive opportunity.

The fact that AML is now on the table is a game changer.

I know the world is in an even bigger game changer, but, this too shall pass.

Time is on our side. Just the fact that AML trial is finally seeing the light of day is so so positive in so many ways, period.
by Ryan
Mon Mar 16, 2020 5:51 pm
Forum: ImetelChat
Topic: Off-topic: Virus do target stem cells
Replies: 0
Views: 1535

Off-topic: Virus do target stem cells

Nothing to say on geron but keep waiting, in the meantime some light reading from Oxford: https://academic.oup.com/femsle/article/226/2/203/577444#94296349 If you want to read about why I am so confident on Imetelstat, still, find the “Imetelstat AML” ASH abstract from 2016, or find Dr Rizo’s brief ...
by Ryan
Sat Mar 14, 2020 9:41 pm
Forum: ImetelChat
Topic: AML - Q4
Replies: 6
Views: 2345

Re: AML - Q4

Another point to add to my AML thoughts (&optimisn): - The groundbreaking AML preclinical data for Imetelstat was published at ASH 2016. This data was stunning and called for / merited additional studies. Since then, so long ago, not a peep about another AML study. Now, all of a sudden, there is a p...
by Ryan
Sat Mar 14, 2020 12:18 am
Forum: ImetelChat
Topic: Good Bye
Replies: 4
Views: 1351

Re: Good Bye

Bravo, STA. I agree with you each and every point.

Imetelstat will be approved, moving through the finish line of the Byzantine FDA process. It’s the when that is the only question.
by Ryan
Fri Mar 13, 2020 5:13 am
Forum: ImetelChat
Topic: AML - Q4
Replies: 6
Views: 2345

Re: AML - Q4

I tend to agree, but trying to anticipate that is not a leap I’m willing to make. Q2 is a couple weeks away. Additional data from both studies at a medical conference piqued my interest. Hopefully these conferences actually happen - I assume they will publish abstracts at the very least. If ASH does...
by Ryan
Thu Mar 12, 2020 9:21 pm
Forum: ImetelChat
Topic: AML - Q4
Replies: 6
Views: 2345

AML - Q4

I’m pleased.

MF still in FDAs hands.

MDS moving forward, towards almost certain success. Horizon still far away.

AML study to commence in Q4. Three things in my mind:
- It’s a beautiful thing.
- A partner will surface (imo)
- Finally
by Ryan
Mon Feb 17, 2020 10:18 pm
Forum: ImetelChat
Topic: stock options
Replies: 5
Views: 2012

Re: stock options

Thanks for consolidating the option #s by year.

I may be wrong, but I don’t believe the lawyer Rosenstein sold all his shares when he made a sale before the Janssen decision.
by Ryan
Fri Feb 14, 2020 12:31 am
Forum: ImetelChat
Topic: A Salute to Memom
Replies: 5
Views: 2113

Re: A Salute to Memom

Very true, recently lost my Dad who battled for years against blood cancer (CML) ~ ironically (if that’s the right word) I was in GERN long before his diagnosis, and I’m staying in the fight in his honor. Lost my Mom to breast cancer, and was truly saddened when Imet failed in early phase solid tumo...
by Ryan
Thu Feb 13, 2020 3:49 am
Forum: ImetelChat
Topic: A Salute to Memom
Replies: 5
Views: 2113

Re: A Salute to Memom

Thanks for sharing.
by Ryan
Sun Feb 09, 2020 9:33 pm
Forum: ImetelChat
Topic: Hat tip to hay flick YMB
Replies: 4
Views: 1795

Re: Hat tip to hay flick YMB

Still all about the trial(s), but this is interesting. Thanks to hay flick, even the name delivers knowledge, but there is no “limit” to the knowledge and latest news he’s delivering. (It’s a nerd joke.)