Search found 56 matches

by Ryan
Mon Feb 17, 2020 10:18 pm
Forum: ImetelChat
Topic: stock options
Replies: 5
Views: 664

Re: stock options

Thanks for consolidating the option #s by year.

I may be wrong, but I don’t believe the lawyer Rosenstein sold all his shares when he made a sale before the Janssen decision.
by Ryan
Fri Feb 14, 2020 12:31 am
Forum: ImetelChat
Topic: A Salute to Memom
Replies: 5
Views: 792

Re: A Salute to Memom

Very true, recently lost my Dad who battled for years against blood cancer (CML) ~ ironically (if that’s the right word) I was in GERN long before his diagnosis, and I’m staying in the fight in his honor. Lost my Mom to breast cancer, and was truly saddened when Imet failed in early phase solid tumo...
by Ryan
Thu Feb 13, 2020 3:49 am
Forum: ImetelChat
Topic: A Salute to Memom
Replies: 5
Views: 792

Re: A Salute to Memom

Thanks for sharing.
by Ryan
Sun Feb 09, 2020 9:33 pm
Forum: ImetelChat
Topic: Hat tip to hay flick YMB
Replies: 3
Views: 616

Re: Hat tip to hay flick YMB

Still all about the trial(s), but this is interesting. Thanks to hay flick, even the name delivers knowledge, but there is no “limit” to the knowledge and latest news he’s delivering. (It’s a nerd joke.)
by Ryan
Sun Nov 24, 2019 4:52 pm
Forum: ImetelChat
Topic: ASH 2019
Replies: 3
Views: 1550

Re: ASH 2019

Yes, that was in regard to the Phase III patients, who are enrolling now. I am talking about the Phase II patient cohort. Last data cut was EHA in the summer and we may see updated data, which could allow us to learn more about the durability of the TI. One patient had gone from high transfusion bur...
by Ryan
Sat Nov 23, 2019 11:55 pm
Forum: ImetelChat
Topic: ASH 2019
Replies: 3
Views: 1550

ASH 2019

Well there have been numerous ‘big’ ASH events / abstracts for Geron in the past several years. They all seem to come in like a lion and out like a lamb. (Not the least of which was Dr. Tefferi’s abstract in 2013, which revealed efficacy in both indications across a handful of patients. Stock went u...
by Ryan
Sat Nov 09, 2019 11:50 pm
Forum: ImetelChat
Topic: Dr. Uwe Platzbecker
Replies: 1
Views: 1100

Dr. Uwe Platzbecker

In the ASH disclosures, I see that Dr P, who will be flying from Europe to be the presenter of the poster at ASH, is a Consultant for Novartis, a Consultant for Celgene, and a Consultant for Abbvie.

Rest assured these trials are in good hands and have the interest of large biopharmas.
by Ryan
Fri Nov 08, 2019 6:17 pm
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 1969

Re: Ash posters

In regards to the conference call, Dr. Rizo did most of the talking... She explained everything going on pretty succinctly imo, and the bit of color regarding sequential dosing was of interest. As she stressed, there is a lot of critical thinking to be done for these combos, completely new terrain a...
by Ryan
Thu Nov 07, 2019 6:56 pm
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 1969

Re: Ash posters

Patience is an easy concept but difficult in practice. These trials are supremely trying he patience of all (hand raise), but it doesn’t change that the scientific progress has been nothing short of spectacular. I’ll add the key executive hires in the past year into that adjective spectacular. Those...
by Ryan
Wed Nov 06, 2019 7:40 pm
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 1969

Re: Ash posters

What we found out this morning: - Combo trials are in play * Would love to see the AML combo re-emerge soon - MDS updated data is coming * Would love to see continued durability of Transfusion Independence. At what point is the TI 'tantamount to a cure'?;) - Pre-clinical research and investigation i...
by Ryan
Sun Oct 20, 2019 10:31 pm
Forum: ImetelChat
Topic: Dr. Rizo Abstracts
Replies: 1
Views: 1262

Dr. Rizo Abstracts

As we know, Dr. Rizo has been a contributor on numerous abstracts during her distinguished career, and as has been documented here, her name has appeared on Imetelstat abstracts as part of the Janssen team. So I would not be surprised to see a new Imetelstat abstract released for ASH this year... ho...
by Ryan
Sun Oct 06, 2019 2:58 am
Forum: ImetelChat
Topic: New Corporate presentation
Replies: 4
Views: 1836

Re: New Corporate presentation

Fast Track was achieved much earlier in MDS Phase II because the goal of Transfusion Independence was achieved quickly for patients. Now the MDS indication is moving into late stage for patients with specific biomarkers, and again these TIs could come quickly. Within 6 months we could (*should) have...
by Ryan
Mon Sep 30, 2019 7:02 pm
Forum: ImetelChat
Topic: Full Separation from Janssen???
Replies: 2
Views: 1052

Full Separation from Janssen???

The company has stated Q3 for full separation - and here we are, we hear nothing. Is this separation not a material event worthy of a PR? Or has it not happened? And while we’re at it, what is that very small 2nd Agreement all about, and why is it beneficial to Geron and owners? As you can see, more...
by Ryan
Sun Sep 29, 2019 2:02 am
Forum: ImetelChat
Topic: Novel Strategies for the Treatment of MF - Sept 2019
Replies: 1
Views: 789

Novel Strategies for the Treatment of MF - Sept 2019

Shout out to EarFool on Yahoo for posting this https://f1000research.com/articles/8-1662 Imetelstat is highlighted in the Novel Agents section. Man I could use a bone at next week’s conference - road weary - I suspect that the full freedom from Janssen will be announced at some point next week. That...
by Ryan
Sat Aug 10, 2019 9:28 pm
Forum: ImetelChat
Topic: P III
Replies: 5
Views: 2848

Re: P III

Finally is perhaps the understatement of the century Future is bright; success of Phase III MDS I peg above 95%. (Success of the MF FDA regulatory discussions, measured solely by accelerated approval, I’d put at around 45%) The past decade is full of successes for Imetelstat (and it’s team and colla...
by Ryan
Tue Aug 06, 2019 6:53 pm
Forum: ImetelChat
Topic: Imetelstat: The First Disease-Modifying Drug for Myelodysplastic Syndromes?
Replies: 4
Views: 2051

Imetelstat: The First Disease-Modifying Drug for Myelodysplastic Syndromes?

I don't think anyone has posted this fantastic overview from the conference / confirmation of the breakthrough data from Imetelstat presented. Imetelstat is the headline story of this conference review: https://www.emjreviews.com/hematology/congress-review/review-of-the-european-hematology-associati...
by Ryan
Mon Jul 29, 2019 8:11 pm
Forum: ImetelChat
Topic: Janssen Patent Application
Replies: 3
Views: 1987

Re: Janssen Patent Application

Hello J, Remember, Geron continues to have a, much smaller, deal with Janssen that continues to be in effect - it was a $5Million at signing, I believe the potential is $75 Million more plus single digits % royalties on any “product” revenues. This is a question that I am kicking myself for not aski...
by Ryan
Wed Jun 26, 2019 7:50 pm
Forum: ImetelChat
Topic: Tues conference
Replies: 5
Views: 3051

Re: Tues conference

Seems that every message board is filled with loathe from this meeting. If you look at the slides it tells a very different story. Change my handle from Ryan to Pollyanna I suppose :mrgreen: Even I tried to inject some magical happening that was going to happen, with thoughts of expanded cohorts for...
by Ryan
Tue Jun 25, 2019 12:54 am
Forum: ImetelChat
Topic: Tues conference
Replies: 5
Views: 3051

Re: Tues conference

Dr. Feneaux was quoted in OncLive article as saying a study in higher risk MDS patients was being planned. Do we hear something of either an academic institution stepping on to do a study or a corporate collaboration to include a high risk MDS cohort in the Phase III? That would be the only thing I ...