Search found 62 matches

by Ryan
Wed Mar 18, 2020 9:37 pm
Forum: ImetelChat
Topic: AML - Q4
Replies: 6
Views: 1319

Re: AML - Q4

AML is such a massive opportunity.

The fact that AML is now on the table is a game changer.

I know the world is in an even bigger game changer, but, this too shall pass.

Time is on our side. Just the fact that AML trial is finally seeing the light of day is so so positive in so many ways, period.
by Ryan
Mon Mar 16, 2020 5:51 pm
Forum: ImetelChat
Topic: Off-topic: Virus do target stem cells
Replies: 0
Views: 641

Off-topic: Virus do target stem cells

Nothing to say on geron but keep waiting, in the meantime some light reading from Oxford: https://academic.oup.com/femsle/article/226/2/203/577444#94296349 If you want to read about why I am so confident on Imetelstat, still, find the “Imetelstat AML” ASH abstract from 2016, or find Dr Rizo’s brief ...
by Ryan
Sat Mar 14, 2020 9:41 pm
Forum: ImetelChat
Topic: AML - Q4
Replies: 6
Views: 1319

Re: AML - Q4

Another point to add to my AML thoughts (&optimisn): - The groundbreaking AML preclinical data for Imetelstat was published at ASH 2016. This data was stunning and called for / merited additional studies. Since then, so long ago, not a peep about another AML study. Now, all of a sudden, there is a p...
by Ryan
Sat Mar 14, 2020 12:18 am
Forum: ImetelChat
Topic: Good Bye
Replies: 3
Views: 611

Re: Good Bye

Bravo, STA. I agree with you each and every point.

Imetelstat will be approved, moving through the finish line of the Byzantine FDA process. It’s the when that is the only question.
by Ryan
Fri Mar 13, 2020 5:13 am
Forum: ImetelChat
Topic: AML - Q4
Replies: 6
Views: 1319

Re: AML - Q4

I tend to agree, but trying to anticipate that is not a leap I’m willing to make. Q2 is a couple weeks away. Additional data from both studies at a medical conference piqued my interest. Hopefully these conferences actually happen - I assume they will publish abstracts at the very least. If ASH does...
by Ryan
Thu Mar 12, 2020 9:21 pm
Forum: ImetelChat
Topic: AML - Q4
Replies: 6
Views: 1319

AML - Q4

I’m pleased.

MF still in FDAs hands.

MDS moving forward, towards almost certain success. Horizon still far away.

AML study to commence in Q4. Three things in my mind:
- It’s a beautiful thing.
- A partner will surface (imo)
- Finally
by Ryan
Mon Feb 17, 2020 10:18 pm
Forum: ImetelChat
Topic: stock options
Replies: 5
Views: 1368

Re: stock options

Thanks for consolidating the option #s by year.

I may be wrong, but I don’t believe the lawyer Rosenstein sold all his shares when he made a sale before the Janssen decision.
by Ryan
Fri Feb 14, 2020 12:31 am
Forum: ImetelChat
Topic: A Salute to Memom
Replies: 5
Views: 1518

Re: A Salute to Memom

Very true, recently lost my Dad who battled for years against blood cancer (CML) ~ ironically (if that’s the right word) I was in GERN long before his diagnosis, and I’m staying in the fight in his honor. Lost my Mom to breast cancer, and was truly saddened when Imet failed in early phase solid tumo...
by Ryan
Thu Feb 13, 2020 3:49 am
Forum: ImetelChat
Topic: A Salute to Memom
Replies: 5
Views: 1518

Re: A Salute to Memom

Thanks for sharing.
by Ryan
Sun Feb 09, 2020 9:33 pm
Forum: ImetelChat
Topic: Hat tip to hay flick YMB
Replies: 4
Views: 1308

Re: Hat tip to hay flick YMB

Still all about the trial(s), but this is interesting. Thanks to hay flick, even the name delivers knowledge, but there is no “limit” to the knowledge and latest news he’s delivering. (It’s a nerd joke.)
by Ryan
Sun Nov 24, 2019 4:52 pm
Forum: ImetelChat
Topic: ASH 2019
Replies: 3
Views: 1648

Re: ASH 2019

Yes, that was in regard to the Phase III patients, who are enrolling now. I am talking about the Phase II patient cohort. Last data cut was EHA in the summer and we may see updated data, which could allow us to learn more about the durability of the TI. One patient had gone from high transfusion bur...
by Ryan
Sat Nov 23, 2019 11:55 pm
Forum: ImetelChat
Topic: ASH 2019
Replies: 3
Views: 1648

ASH 2019

Well there have been numerous ‘big’ ASH events / abstracts for Geron in the past several years. They all seem to come in like a lion and out like a lamb. (Not the least of which was Dr. Tefferi’s abstract in 2013, which revealed efficacy in both indications across a handful of patients. Stock went u...
by Ryan
Sat Nov 09, 2019 11:50 pm
Forum: ImetelChat
Topic: Dr. Uwe Platzbecker
Replies: 1
Views: 1186

Dr. Uwe Platzbecker

In the ASH disclosures, I see that Dr P, who will be flying from Europe to be the presenter of the poster at ASH, is a Consultant for Novartis, a Consultant for Celgene, and a Consultant for Abbvie.

Rest assured these trials are in good hands and have the interest of large biopharmas.
by Ryan
Fri Nov 08, 2019 6:17 pm
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 2145

Re: Ash posters

In regards to the conference call, Dr. Rizo did most of the talking... She explained everything going on pretty succinctly imo, and the bit of color regarding sequential dosing was of interest. As she stressed, there is a lot of critical thinking to be done for these combos, completely new terrain a...
by Ryan
Thu Nov 07, 2019 6:56 pm
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 2145

Re: Ash posters

Patience is an easy concept but difficult in practice. These trials are supremely trying he patience of all (hand raise), but it doesn’t change that the scientific progress has been nothing short of spectacular. I’ll add the key executive hires in the past year into that adjective spectacular. Those...
by Ryan
Wed Nov 06, 2019 7:40 pm
Forum: ImetelChat
Topic: Ash posters
Replies: 9
Views: 2145

Re: Ash posters

What we found out this morning: - Combo trials are in play * Would love to see the AML combo re-emerge soon - MDS updated data is coming * Would love to see continued durability of Transfusion Independence. At what point is the TI 'tantamount to a cure'?;) - Pre-clinical research and investigation i...
by Ryan
Sun Oct 20, 2019 10:31 pm
Forum: ImetelChat
Topic: Dr. Rizo Abstracts
Replies: 1
Views: 1341

Dr. Rizo Abstracts

As we know, Dr. Rizo has been a contributor on numerous abstracts during her distinguished career, and as has been documented here, her name has appeared on Imetelstat abstracts as part of the Janssen team. So I would not be surprised to see a new Imetelstat abstract released for ASH this year... ho...
by Ryan
Sun Oct 06, 2019 2:58 am
Forum: ImetelChat
Topic: New Corporate presentation
Replies: 4
Views: 1998

Re: New Corporate presentation

Fast Track was achieved much earlier in MDS Phase II because the goal of Transfusion Independence was achieved quickly for patients. Now the MDS indication is moving into late stage for patients with specific biomarkers, and again these TIs could come quickly. Within 6 months we could (*should) have...
by Ryan
Mon Sep 30, 2019 7:02 pm
Forum: ImetelChat
Topic: Full Separation from Janssen???
Replies: 2
Views: 1105

Full Separation from Janssen???

The company has stated Q3 for full separation - and here we are, we hear nothing. Is this separation not a material event worthy of a PR? Or has it not happened? And while we’re at it, what is that very small 2nd Agreement all about, and why is it beneficial to Geron and owners? As you can see, more...